Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current ( I K,ACh ).

Autor: Veerman CC; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands., Mengarelli I; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands., Koopman CD; Department of Medical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Hubrecht Institute, 3584 CT Utrecht, The Netherlands., Wilders R; Amsterdam UMC, University of Amsterdam, Department of Medical Biology, Heart Failure Research Center, 1105 AZ Amsterdam, The Netherlands., van Amersfoorth SC; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands., Bakker D; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands., Wolswinkel R; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands., Hababa M; Hubrecht Institute, 3584 CT Utrecht, The Netherlands., de Boer TP; Department of Medical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Guan K; Department of Pharmacology and Toxicology, Technische Universität Dresden, 01062 Dresden, Germany., Milnes J; Xention Ltd, Cambridge CB22 3EG, UK., Lodder EM; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands., Bakkers J; Department of Medical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Hubrecht Institute, 3584 CT Utrecht, The Netherlands., Verkerk AO; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands.; Amsterdam UMC, University of Amsterdam, Department of Medical Biology, Heart Failure Research Center, 1105 AZ Amsterdam, The Netherlands., Bezzina CR; Amsterdam UMC, University of Amsterdam, Department of Experimental Cardiology, Heart Center, 1105 AZ Amsterdam, The Netherlands c.r.bezzina@amc.uva.nl.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2019 Jul 09; Vol. 12 (7). Date of Electronic Publication: 2019 Jul 09.

Spatial Heterogeneity of Cx43 is an Arrhythmogenic Substrate of Polymorphic Ventricular Tachycardias during Compensated Cardiac Hypertrophy in Rats.

Autor: Boulaksil M; Interuniversity Cardiology Institute of the Netherlands, Utrecht, Netherlands; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Bierhuizen MF; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht , Netherlands., Engelen MA; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Division of Cardiology, Department of Cardiovascular Medicine, University of Muenster, Muenster, Germany., Stein M; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht, Netherlands., Kok BJ; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht , Netherlands., van Amersfoorth SC; Heart Failure Research Center, Academic Medical Center , Amsterdam , Netherlands., Vos MA; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht , Netherlands., van Rijen HV; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht , Netherlands., de Bakker JM; Interuniversity Cardiology Institute of the Netherlands, Utrecht, Netherlands; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Heart Failure Research Center, Academic Medical Center, Amsterdam, Netherlands., van Veen TA; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht , Utrecht , Netherlands.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2016 Mar 02; Vol. 3, pp. 5. Date of Electronic Publication: 2016 Mar 02 (Print Publication: 2016).

Atrial fibrosis and conduction slowing in the left atrial appendage of patients undergoing thoracoscopic surgical pulmonary vein isolation for atrial fibrillation.

Autor: Krul SP; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., Berger WR; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., Smit NW; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., van Amersfoorth SC; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., Driessen AH; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., van Boven WJ; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., Fiolet JW; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., van Ginneken AC; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., van der Wal AC; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., de Bakker JM; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., Coronel R; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.)., de Groot JR; From the Heart Center, Departments of Clinical and Experimental Cardiology (S.P.J.K., W.R.B., N.W.S., S.C.M.v.A., J.W.T.F., J.M.T.d.B., R.C., J.R.d.G.) and Cardiothoracic Surgery (A.H.G.D., W.J.v.B.), Departments of Anatomy, Embryology, and Physiology (A.C.G.v.G.) and Pathology (A.C.v.d.W.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands (J.M.T.d.B.); and L'Institut de RYthmologie et Modélisation Cardiaque (LIRYC), Université de Bordeaux, Bordeaux, France (R.C.). j.r.degroot@amc.uva.nl.

Publikováno v: Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2015 Apr; Vol. 8 (2), pp. 288-95. Date of Electronic Publication: 2015 Feb 11.

Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.

Autor: Fabritz L; Department of Cardiology and Angiology, Hospital of the University of Muenster, Germany., Hoogendijk MG, Scicluna BP, van Amersfoorth SC, Fortmueller L, Wolf S, Laakmann S, Kreienkamp N, Piccini I, Breithardt G, Noppinger PR, Witt H, Ebnet K, Wichter T, Levkau B, Franke WW, Pieperhoff S, de Bakker JM, Coronel R, Kirchhof P

Publikováno v: Journal of the American College of Cardiology [J Am Coll Cardiol] 2011 Feb 08; Vol. 57 (6), pp. 740-50.

Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer.

Autor: Boink GJ; Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Verkerk AO, van Amersfoorth SC, Tasseron SJ, van der Rijt R, Bakker D, Linnenbank AC, van der Meulen J, de Bakker JM, Seppen J, Tan HL

Publikováno v: The journal of gene medicine [J Gene Med] 2008 May; Vol. 10 (5), pp. 487-97.