Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients.

Autor: Deben DS; Department of Clinical Pharmacy, Clinical pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., van Adrichem AJ; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Drent R; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Puts S; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Pelzer KEJM; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., van Bodegraven AA; Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (Co-MIK), Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Wong DR; Department of Clinical Pharmacy, Clinical pharmacology and Toxicology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands., Leers MPG; Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre Sittard-Geleen, Heerlen, The Netherlands.

Publikováno v: Cytometry. Part A : the journal of the International Society for Analytical Cytology [Cytometry A] 2022 Feb; Vol. 101 (2), pp. 167-176. Date of Electronic Publication: 2021 Oct 08.

Identification of novel regulators of STAT3 activity.

Autor: Parri E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Kuusanmäki H; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark., van Adrichem AJ; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Kaustio M; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Wennerberg K; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark.

Publikováno v: PloS one [PLoS One] 2020 Mar 31; Vol. 15 (3), pp. e0230819. Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020).

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.

Autor: Tang J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland; Department of Mathematics and Statistics, University of Turku, 20014 Turku, Finland. Electronic address: jing.tang@helsinki.fi., Tanoli ZU; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Ravikumar B; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Alam Z; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Rebane A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Vähä-Koskela M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Peddinti G; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., van Adrichem AJ; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Wakkinen J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Jaiswal A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Karjalainen E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Gautam P; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., He L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Parri E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Khan S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Gupta A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Ali M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Yetukuri L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Gustavsson AL; Chemical Biology Consortium Sweden, Karolinska Institutet, 17165 Stockholm, Sweden., Seashore-Ludlow B; Chemical Biology Consortium Sweden, Karolinska Institutet, 17165 Stockholm, Sweden., Hersey A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK., Leach AR; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK., Overington JP; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK; Medicines Discovery Catapult, Mereside, Alderley Park, Alderley Edge, Cheshire SK10 4TG, UK., Repasky G; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland. Electronic address: krister.wennerberg@helsinki.fi., Aittokallio T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland; Department of Mathematics and Statistics, University of Turku, 20014 Turku, Finland. Electronic address: tero.aittokallio@helsinki.fi.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2018 Feb 15; Vol. 25 (2), pp. 224-229.e2. Date of Electronic Publication: 2017 Dec 21.

High-Throughput Dual Screening Method for Ras Activities and Inhibitors.

Autor: Kopra K; Institute of Biomedicine, University of Turku , Kiinamyllynkatu 10 C, FI-20520 Turku, Finland., van Adrichem AJ; Institute for Molecular Medicine Finland, University of Helsinki , Tukholmankatu 8, FI-00290 Helsinki, Finland., Salo-Ahen OMH; Structural Bioinformatics Laboratory and Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Biochemistry and Pharmacy, Åbo Akademi University , Tykistökatu 6A, FI-20520 Turku, Finland., Peltonen J; Institute of Biomedicine, University of Turku , Kiinamyllynkatu 10 C, FI-20520 Turku, Finland., Wennerberg K; Institute for Molecular Medicine Finland, University of Helsinki , Tukholmankatu 8, FI-00290 Helsinki, Finland., Härmä H; Institute of Biomedicine, University of Turku , Kiinamyllynkatu 10 C, FI-20520 Turku, Finland.

Publikováno v: Analytical chemistry [Anal Chem] 2017 Apr 18; Vol. 89 (8), pp. 4508-4516. Date of Electronic Publication: 2017 Mar 29.

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

Autor: Haapaniemi EM; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology, and., Kaustio M; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;, Rajala HL; Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Cancer Center, Helsinki, Finland;, van Adrichem AJ; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;, Kainulainen L; Department of Pediatrics and Department of Medicine, Turku University Hospital, Turku, Finland;, Glumoff V; Department of Medical Microbiology and Immunology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;, Doffinger R; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital and National Institute for Health Research, Cambridge Biomedical Research Center, Cambridge, United Kingdom;, Kuusanmäki H; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;, Heiskanen-Kosma T; Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland;, Trotta L; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;, Chiang S; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden;, Kulmala P; Department of Medical Microbiology and Immunology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Pediatrics, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;, Eldfors S; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;, Katainen R; Department of Medical Genetics, Genome-Scale Biology Research Program, Institute of Biomedicine, University of Helsinki, Helsinki, Finland;, Siitonen S; Laboratory Services (Hospital District of Helsinki and Uusimaa Laboratory)., Karjalainen-Lindsberg ML; Laboratory Services (Hospital District of Helsinki and Uusimaa Laboratory)., Kovanen PE; Department of Pathology, and., Otonkoski T; Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland;, Porkka K; Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Cancer Center, Helsinki, Finland;, Heiskanen K; Children's Hospital, Helsinki University Central Hospital, Helsinki, Finland., Hänninen A; Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland;, Bryceson YT; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden;, Uusitalo-Seppälä R; Department of Infectious Diseases, Satakunta Central Hospital, Pori, Finland;, Saarela J; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland;, Seppänen M; Immunodeficiency Unit, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland; and., Mustjoki S; Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Central Hospital Cancer Center, Helsinki, Finland;, Kere J; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology, and Department of Biosciences and Nutrition, and Center for Innovative Medicine, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: Blood [Blood] 2015 Jan 22; Vol. 125 (4), pp. 639-48. Date of Electronic Publication: 2014 Oct 27.