Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

Autor: Tang, Jing, Tanoli, Zia-ur-Rehman, Ravikumar, Balaguru, Alam, Zaid, Rebane, Anni, Vähä-Koskela, Markus, Peddinti, Gopal, van Adrichem, Arjan J., Wakkinen, Janica, Jaiswal, Alok, Karjalainen, Ella, Gautam, Prson, He, Liye, Parri, Elina, Khan, Suleiman, Gupta, Abhishekh, Ali, Mehreen, Yetukuri, Laxman, Gustavsson, Anna-Lena, Seashore-Ludlow, Brinton, Hersey, Anne, Leach, Andrew R., Overington, John P., Repasky, Gretchen, Wennerberg, Krister, Aittokallio, Tero

Publikováno v: In Cell Chemical Biology 15 February 2018 25(2):224-229

A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients

Autor: Deben, Debbie S, Creemers, Rob H, van Adrichem, Arjan J, Drent, Roosmarie, Merry, Audrey H H, Leers, Mathie P G, van Bodegraven, Adriaan A, Wong, Dennis R

Publikováno v: Deben, D S, Creemers, R H, van Adrichem, A J, Drent, R, Merry, A H H, Leers, M P G, van Bodegraven, A A & Wong, D R 2022, ' A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients ', Scientific Reports, vol. 12, no. 1, 15806 . https://doi.org/10.1038/s41598-022-20197-5
Scientific Reports, 12(1):15806. Nature Publishing Group

The thiopurine derivatives azathioprine (AZA), mercaptopurine (MP) and tioguanine (TG) remain standard treatment of inflammatory bowel disease (IBD). The immune suppressive effect of thiopurines is primarily based on blocking the Ras-related C3 botul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbc2f106cd927332072a5f143dea7d9
https://doi.org/10.1038/s41598-022-20197-5

MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1–regulated pathways in mice

Autor: Meenhuis, Annemarie ^*, van Veelen, Peter A. ^*, de Looper, Hans, van Boxtel, Nicole, van den Berge, Iris J., Sun, Su M., Taskesen, Erdogan, Stern, Patrick, de Ru, Arnoud H., van Adrichem, Arjan J., Demmers, Jeroen, Jongen-Lavrencic, Mojca, Löwenberg, Bob, Touw, Ivo P., Sharp, Phillip A., Erkeland, Stefan J.

Publikováno v: In Blood 28 July 2011 118(4):916-925

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Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients.

Autor: Deben, Debbie S., van Adrichem, Arjan J., Drent, Roosmarie, Puts, Sabine, Pelzer, Kelly E. J. M., van Bodegraven, Adriaan A., Wong, Dennis R., Leers, Mathie P. G.

Publikováno v: Cytometry. Part A; Feb2022, Vol. 101 Issue 2, p167-176, 10p