Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Autor: Strawbridge, Rj, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, Jr, Travers, Me, Bouatia Naji, N, Dimas, As, Nica, A, Wheeler, E, Chen, H, Voight, Bf, Taneera, J, Kanoni, S, Peden, Jf, Turrini, F, Gustafsson, S, Zabena, C, Almgren, P, Barker, Dj, Barnes, D, Dennison, Em, Eriksson, Jg, Eriksson, P, Eury, E, Folkersen, L, Fox, Cs, Frayling, Tm, Goel, A, Gu, Hf, Horikoshi, M, Isomaa, B, Jackson, Au, Jameson, Ka, Kajantie, E, Kerr Conte, J, Kuulasmaa, T, Kuusisto, J, Loos, Rj, Luan, J, Makrilakis, K, Manning, Ak, Martínez Larrad MT, Narisu, N, Nastase Mannila, M, Ohrvik, J, Osmond, C, Pascoe, L, Payne, F, Sayer, Aa, Sennblad, B, Silveira, A, Stancáková, A, Stirrups, K, Swift, Aj, Syvänen, Ac, Tuomi, T, van 't Hooft FM, Walker, M, Weedon, Mn, Xie, W, Zethelius, B, Diagram, Consortium, Giant, Consortium, Muther, Consortium, Cardiogram, Consortium, C4d, Consortium, Ongen, H, Mälarstig, A, Hopewell, Jc, Saleheen, D, Chambers, J, Parish, S, Danesh, J, Kooner, J, Ostenson, Cg, Lind, L, Cooper, Cc, Serrano Ríos, M, Ferrannini, E, Forsen, Tj, Clarke, R, Franzosi, Mg, Seedorf, U, Watkins, H, Froguel, P, Johnson, P, Deloukas, P, Collins, Fs, Laakso, M, Dermitzakis, Et, Boehnke, M, Mccarthy, Mi, Wareham, Nj, Groop, L, Pattou, F, Gloyn, Al, Dedoussis, Gv, Lyssenko, V, Meigs, Jb, Barroso, I, Watanabe, Rm, Ingelsson, E, Langenberg, C, Hamsten, A, Voight BF, Florez J. C., Scott, Lj, Steinthorsdottir, V, Morris, Ap, Dina, C, Welch, Rp, Zeggini, E, Huth, C, Aulchenko, Ys, Thorleifsson, G, Mcculloch, Lj, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, Cj, Raychaudhuri, S, Mccarroll, Sa, Hofmann, Om, Qi, L, Segrè, Av, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, Aj, Blagieva, R, Boerwinkle, E, Bonnycastle, Ll, Bengtsson Boström, K, Bravenboer, B, Bumpstead, S, Burtt, P, Charpentier, G, Chines, Ps, Cornelis, M, Couper, Dj, Crawford, G, Doney, As, Elliott, Ks, Elliott, Al, Erdos, Mr, Franklin, Cs, Gieger, C, Grarup, N, Green, T, Griffin, S, Groves, Cj, Guiducci, C, Hadjadj, S, Hassanali, N, Herder, C, Johnson, Pr, Jørgensen, T, Kao, Wh, Klopp, N, Kong, A, Kraft, P, Lauritzen, T, Li, M, Lieverse, A, Lindgren, Cm, Marre, M, Meitinger, T, Midthjell, K, Morken, Ma, Nilsson, P, Owen, Kr, Perry, Jr, Petersen, K, Platou, C, Proença, C, Rathmann, W, William Rayner, N, Robertson, Nr, Rocheleau, G, Roden, M, Sampson, Mj, Saxena, R, Shields, Bm, Shrader, P, Sigurdsson, G, Sparsø, T, Strassburger, K, Stringham, Hm, Sun, Q, Thorand, B, Tichet, J, van Dam RM, van Haeften TW, van Herpt, T, van Vliet JV, Bragi Walters, G, Wijmenga, C, Witteman, J, Bergman, Rn, Cauchi, S, Gyllensten, U, Hansen, T, Hide, Wa, Hitman, Ga, Hofman, A, Hunter, Dj, Hveem, K, Mohlke, Kl, Morris, Ad, Palmer, Cn, Pramstaller, Pp, Rudan, I, Sijbrands, E, Stein, Ld, Tuomilehto, J, Uitterlinden, A, Abecasis, Gr, Boehm, Bo, Campbell, H, Daly, Mj, Hattersley, At, Hu, Fb, Pankow, Js, Pedersen, O, Wichmann, E, Florez, Jc, Sladek, R, Thorsteinsdottir, U, Wilson, Jf, Illig, T, Stefansson, K, Altshuler, D, Speliotes, Ek, Berndt, Si, Monda, Kl, Allen, Hl, Mägi, R, Randall, Jc, Vedantam, S, Winkler, Tw, Workalemahu, T, Heid, Im, Wood, Ar, Weyant, Rj, Estrada, K, Liang, L, Nemesh, J, Park, Jh, Kilpeläinen, To, Yang, J, Esko, T, Feitosa, Mf, Kutalik, Z, Mangino, M, Scherag, A, Smith, Av, Welch, R, Zhao, Jh, Aben, Kk, Absher, Dm, Dixon, Al, Fisher, E, Glazer, Nl, Goddard, Me, Heard Costa NL, Hoesel, V, Hottenga, Jj, Johansson, Å, Johnson, T, Ketkar, S, Lamina, C, Li, S, Moffatt, Mf, Myers, Rh, Peters, Mj, Preuss, M, Ripatti, S, Rivadeneira, F, Sandholt, C, Timpson, Nj, Tyrer, Jp, van Wingerden, S, White, Cc, Wiklund, F, Barlassina, C, Chasman, Di, Cooper, Mn, Jansson, Jo, Lawrence, Rw, Pellikka, N, Shi, J, Thiering, E, Alavere, H, Alibrandi, Mt, Arnold, Am, Aspelund, T, Atwood, Ld, Balmforth, Aj, Ben Shlomo, Y, Bergmann, S, Biebermann, H, Blakemore, Ai, Boes, T, Bornstein, Sr, Brown, Mj, Buchanan, Ta, Busonero, F, Cappuccio, Fp, Cavalcanti Proença, C, Ida Chen YD, Chen, Cm, Coin, L, Connell, J, Day, In, den Heijer, M, Duan, J, Ebrahim, S, Elliott, P, Elosua, R, Eiriksdottir, G, Facheris, Mf, Felix, Sb, Fischer Posovszky, P, Folsom, Ar, Friedrich, N, Freimer, Nb, Fu, M, Gaget, S, Gejman, Pv, Geus, Ej, Gjesing, Ap, Goyette, P, Grässler, J, Greenawalt, Dm, Gudnason, V, Hartikainen, Al, Hall, As, Havulinna, As, Hayward, C, Heath, Ac, Hengstenberg, C, Hicks, Aa, Hinney, A, Homuth, G, Hui, J, Igl, W, Iribarren, C, Jacobs, Kb, Jarick, I, Jewell, E, John, U, Jousilahti, P, Jula, A, Kaakinen, M, Kaplan, Lm, Kathiresan, S, Kettunen, J, Kinnunen, L, Knowles, Jw, Kolcic, I, König, Ir, Koskinen, S, Kovacs, P, Kvaløy, K, Laitinen, J, Lantieri, O, Lanzani, C, Launer, Lj, Lecoeur, C, Terho, L, Lettre, G, Liu, J, Lokki, Ml, Lorentzon, M, Luben, Rn, Ludwig, B, Magic, Manunta, P, Marek, D, Martin, Ng, Mcardle, Wl, Mccarthy, A, Mcknight, B, Melander, O, Meyre, D, Montgomery, Gw, Mulic, R, Ngwa, Js, Nelis, M, Neville, Mj, Nyholt, Dr, O'Donnell, Cj, O'Rahilly, S, Ong, Kk, Oostra, B, Paré, G, Parker, An, Perola, M, Pichler, I, Pietiläinen, Kh, Platou, Cg, Polasek, O, Pouta, A, Rafelt, S, Raitakari, O, Rayner, Nw, Ridderstråle, M, Rief, W, Ruokonen, A, Rzehak, P, Salomaa, V, Sanders, Ar, Sandhu, Ms, Sanna, S, Saramies, J, Savolainen, Mj, Scherag, S, Schipf, S, Schreiber, S, Schunkert, H, Silander, K, Sinisalo, J, Siscovick, Ds, Smit, Jh, Soranzo, N, Sovio, U, Stephens, J, Surakka, I, Tammesoo, Ml, Tardif, Jc, Teder Laving, M, Teslovich, Tm, Thompson, Jr, Thomson, B, Tönjes, A, van Meurs JB, van Ommen GJ, Vatin, V, Viikari, J, Visvikis Siest, S, Vitart, V, Vogel, Ci, Waite, Ll, Wallaschofski, H, Walters, Gb, Widen, E, Wiegand, S, Wild, Sh, Willemsen, G, Witte, Dr, Witteman, Jc, Xu, J, Zhang, Q, Zgaga, L, Ziegler, A, Zitting, P, Beilby, Jp, Farooqi, Is, Hebebrand, J, Huikuri, Hv, James, Al, Kähönen, M, Levinson, Df, Macciardi, F, Nieminen, Ms, Ohlsson, C, Palmer, Lj, Ridker, Pm, Stumvoll, M, Beckmann, Js, Boeing, H, Dorret, I. B., Caulfield, Mj, Chanock, Sj, Cupples, La, Smith, Gd, Erdmann, J, Grönberg, H, Hall, P, Harris, Tb, Hayes, Rb, Heinrich, J, Jarvelin, Mr, Kaprio, J, Karpe, F, Khaw, Kt, Kiemeney, La, Krude, H, Lawlor, Da, Metspalu, A, Munroe, Pb, Ouwehand, Wh, Penninx, Bw, Peters, A, Quertermous, T, Reinehr, T, Rissanen, A, Samani, Nj, Schwarz, Pe, Shuldiner, Ar, Spector, Td, Uda, M, Valle, Tt, Wabitsch, M, Waeber, G, Shaun, P, Eric, E. S., Peter, M. V., Assimes, Tl, Borecki, Ib, Groop, Lc, Haritunians, T, Kaplan, Rc, O'Connell, Jr, Peltonen, L, Schlessinger, D, Strachan, Dp, van Duijn CM, Barroso, H, North, Ke, Hirschhorn, Jn, Nica, Ac, Parts, L, Glass, D, Nisbet, J, Barrett, A, Sekowska, M, Travers, M, Potter, S, Grundberg, E, Small, K, Hedman, Åk, Bataille, V, Bell, Jt, Surdulescu, G, Ingle, C, Nestle, Fo, di Meglio, P, Min, Jl, Wilk, A, Hammond, Cj, Yang, Tp, Montgomery, Sb, Zondervan, Kt, Durbin, R, Ahmadi, K, Reilly, Mp, Holm, H, Stewart, Af, Barbalic, M, Absher, D, Aherrahrou, Z, Allayee, H, Anand, Ss, Andersen, K, Anderson, Jl, Ardissino, D, Ball, Sg, Barnes, Ta, Becker, Dm, Becker, Lc, Berger, K, Bis, Jc, Boekholdt, Sm, Braund, Ps, Burnett, Ms, Buysschaert, I, Cardiogenics, Carlquist, Jf, Chen, L, Cichon, S, Codd, V, Davies, Rw, Dedoussis, G, Dehghan, A, Demissie, S, Devaney, Jm, Diemert, P, Do, R, Doering, A, Eifert, S, El Mokhtari NE, Ellis, Sg, Engert, Jc, Epstein, Se, de Faire, U, Fischer, M, Freyer, J, Gigante, B, Girelli, Domenico, Gretarsdottir, S, Gulcher, Jr, Halperin, E, Hammond, N, Hazen, Sl, Horne, Bd, Jones, Gt, Jukema, Jw, Kaiser, Ma, Kastelein, Jj, Kolovou, G, Laaksonen, R, Lambrechts, D, Leander, K, Lieb, W, Loley, C, Lotery, Aj, Mannucci, Pm, Maouche, S, Martinelli, Nicola, Mckeown, Pp, Meisinger, C, Merlini, Pa, Mooser, V, Morgan, T, Mühleisen, Tw, Muhlestein, Jb, Münzel, T, Musunuru, K, Nahrstaedt, J, Nelson, Cp, Nöthen, Mm, Olivieri, Oliviero, Patel, Rs, Patterson, Cc, Peyvandi, F, Qu, L, Quyyumi, Aa, Rader, Dj, Rallidis, Ls, Rice, C, Rosendaal, Fr, Rubin, D, Sampietro, Ml, Schadt, E, Schäfer, A, Schillert, A, Schrezenmeir, J, Schwartz, Sm, Sivananthan, M, Sivapalaratnam, S, Smith, A, Smith, Tb, Snoep, Jd, Spertus, Ja, Stark, K, Stoll, M, Tang, Wh, Tennstedt, S, Thorgeirsson, G, Tomaszewski, M, Uitterlinden, Ag, van Rij AM, Wells, Ga, Wichmann, He, Wild, Ps, Willenborg, C, Wright, Bj, Ye, S, Zeller, T, Cambien, F, Goodall, Ah, März, W, Blankenberg, S, Roberts, R, Mcpherson, R, Nilesh, J. S.

Publikováno v: Morris, A & Rudan, I & Campbell, H & Wilson, J 2011, ' Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes ', Diabetes, vol. 60, no. 10, pp. 2624-34 . https://doi.org/10.2337/db11-0415
Diabetes; Vol 60
Diabetes, Vol. 60, No 10 (2011) pp. 2624-34
Diabetes, 60(10), 2624-2634. American Diabetes Association Inc.
Diabetes, 60, 2624-34
Diabetes, 60(10), 2624-2634. AMER DIABETES ASSOC
Diabetes
Diabetes, 60, 10, pp. 2624-34
Diabetes, 60(10), 2624-2634
Strawbridge, R J, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, J R, Travers, M E, Bouatia-Naji, N, Dimas, A S, Nica, A, Wheeler, E, Chen, H, Voight, B F, Taneera, J, Kanoni, S, Peden, J F, Turrini, F, Gustafsson, S, Zabena, C, Almgren, P, Barker, D J P, Barnes, D, Dennison, E M, Eriksson, J G, Eriksson, P, Eury, E, Folkersen, L, Fox, C S, Frayling, T M, Goel, A, Gu, H F, Horikoshi, M, Isomaa, B, Jackson, A U, Jameson, K A, Kajantie, E, Kerr-Conte, J, Kuulasmaa, T, Kuusisto, J, Loos, R J F, Luan, J, Makrilakis, K, Manning, A K, Martínez-Larrad, M T, Narisu, N, Mannila, M N, the DIAGRAM Consortium (Torsten Lauritzen, Niels Grarup; members), the GIANT Consortium (Daniel R. Witte; member), the MuTHER Consortium, the CARDIoGRAM Consortium & the C4D Consortium 2011, ' Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes ', Diabetes, vol. 60, no. 10, pp. 2624-2634 . https://doi.org/10.2337/db11-0415
Strawbridge, R J, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, J R, Bouatia-Naji, N, Dimas, A S, Nica, A, Wheeler, E, Chen, H, Voight, B F, Taneera, J, Kanoni, S, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Forsen, T J, Clarke, R, Franzosi, M G, Seedorf, U, Watkins, H, Froguel, P, Johnson, P, Deloukas, P, Collins, F S, Laakso, M, Dermitzakis, E T, Boehnke, M, McCarthy, M I, Wareham, N J, Groop, L, Pattou, F, Gloyn, A L, Dedoussis, G V, Lyssenko, V, Meigs, J B, Barroso, I, Watanabe, R M, Ingelsson, E, Langenberg, C, Hamsten, A & Florez, J C 2011, ' Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes ', Diabetes, vol. 60, no. 10, pp. 2624-2634 . https://doi.org/10.2337/db11-0415

OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca4fdf7c5b7d3a200245a047f2fc720
https://hdl.handle.net/20.500.11820/d6fd0145-660e-41a0-96e6-84d3af65fb9b

Growth characteristics of a permanent human endothelial cell line

Autor: van der Laarse A, van 't Hooft Fm, Schaefer Hi

Publikováno v: In vitro cellulardevelopmental biology : journal of the Tissue Culture Association. (7-8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41bd4716897290819c4591056a132b0
https://pubmed.ncbi.nlm.nih.gov/1522039

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Genetic studies of body mass index yield new insights for obesity biology.

Autor: Locke AE; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kahali B; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Powell C; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Vedantam S; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Yang J; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Croteau-Chonka DC; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Esko T; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Fall T; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gustafsson S; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Kutalik Z; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Randall JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Workalemahu T; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Chen J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Fehrmann R; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Hedman ÅK; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands., Anderson D; Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia., Beekman M; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bolton JL; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Bragg-Gresham JL; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, Michigan 48109, USA., Buyske S; Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA.; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Deng G; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Gastroenterology and Hepatology, Imperial College London, London W2 1PG, UK.; Institute of infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Fischer K; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Gong J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Kristiansson K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lim U; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lotay V; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Leach IM; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Medina-Gomez C; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Palmer CD; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Peters MJ; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK., Shungin D; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.; Department of Odontology, Umeå University, Umeå 901 85, Sweden., Stančáková A; University of Eastern Finland, FI-70210 Kuopio, Finland., Strawbridge RJ; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Trompet S; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Laan SW; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Setten J; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Yengo L; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Zhang W; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ärnlöv J; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; School of Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden., Arscott GM; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia., Attwood AP; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy., Barrett A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Bas IN; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Berne C; Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden., Blagieva R; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Blüher M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Böhringer S; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Böttcher Y; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Bruinenberg M; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Caspersen IH; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Chen YI; Department of Pediatrics, University of California Los Angeles, Torrance, California 90502, USA.; Transgenomics Institute, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA., Clarke R; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Daw EW; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., de Craen AJM; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Delgado G; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Doney ASF; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Eklund N; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Estrada K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Eury E; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Folkersen L; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Fraser RM; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Go AS; Kaiser Permanente, Division of Research, Oakland, California 94612, USA., Golay A; Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland., Goodall AH; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, D-93053 Regensburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany., Grallert H; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Grammer TB; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Gräßler J; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Gusto G; Institut inter Régional pour la Santé, Synergies, F-37520 La Riche, France., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Haller T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Hallmans G; Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Heard-Costa NL; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Helmer Q; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Faculty of Psychology and Education, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Hengstenberg C; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Hottenga JJ; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., James AL; Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia., Jeff JM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Johansson Å; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Jolley J; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Juliusdottir T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kinnunen L; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Koenig W; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Koskenvuo M; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Laitinen J; Finnish Institute of Occupational Health, FI-90100 Oulu, Finland., Lamina C; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria., Leander K; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Lindström J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lo KS; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Lobbens S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Lorbeer R; Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mach F; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Merger S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Moayyeri A; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK., Monda KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; The Center for Observational Research, Amgen, Inc., Thousand Oaks, California 91320, USA., Morken MA; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Mulas A; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Müller G; Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia., Nagaraja R; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Nöthen MM; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany., Nolte IM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Pilz S; Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Renstrom F; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden., Rettig R; Institute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Scholtens S; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schumacher FR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Scott WR; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Seufferlein T; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Shi J; National Cancer Institute, Bethesda, Maryland 20892, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Smolonska J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Stanton AV; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Stirrups K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Stringham HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Swertz MA; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Syvänen AC; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden., Tan ST; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., Thorand B; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Tyrer JP; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK., Uh HW; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Verhulst FC; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands., Vermeulen SH; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Genetics, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Vonk JM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Waterworth D; Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Willenborg C; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Zhang Q; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Brennan EP; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Dastani Z; Lady Davis Institute, Departments of Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Eriksson P; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden., Gådin JR; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Gharavi AG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Goddard ME; Biosciences Research Division, Department of Primary Industries, Victoria 3083, Australia.; Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia., Handsaker RE; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK., Kathiresan S; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Keildson S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kiryluk K; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Lee JY; Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363-951, Republic of Korea., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, Massachusetts 2115, USA., Lifton RP; Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA., Ma B; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China., McCarroll SA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., McKnight AJ; Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, County Down BT9 7AB, UK., Min JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Moffatt MF; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Murabito JM; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Nicholson G; Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.; MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0QG, UK., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., Perry JRB; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore., Reinmaa E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Salem RM; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Sandholm N; Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland.; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stolk L; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Tanaka T; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.; Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., van 't Hooft FM; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Vinkhuyzen AAE; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Zheng W; Division of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37075, USA., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK., Heath AC; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Arveiler D; Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Beilby J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California 90048, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA., Bovet P; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Caulfield MJ; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Cesana G; University of Milano, Bicocca, 20126, Italy., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Crawford DC; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA., Cupples LA; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Cusi D; Department of Health Sciences, University of Milano, I 20142, Italy.; Fondazione Filarete, Milano I 20139, Italy., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., den Ruijter HM; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Erbel R; Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany., Erdmann J; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Eriksson JG; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Ferrannini E; Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy.; National Research Council Institute of Clinical Physiology, University of Pisa, 56124 Pisa, Italy., Ferrières J; Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Forrester T; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., Franco OH; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Gejman PV; NorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Gyllensten U; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Hall AS; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Hattersley AT; Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK., Hicks AA; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany)., Hindorff LA; Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Hofman A; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Hovingh GK; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Humphries SE; Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK., Hunt SC; Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA., Hyppönen E; Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.; School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany., Jacobs KB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; National Institute for Health and Welfare, FI-90101 Oulu, Finland.; MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.; Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Johansen B; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Jousilahti P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Jula AM; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kaprio J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kastelein JJP; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Keinanen-Kiukaanniemi SM; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Unit of Primary Health Care/General Practice, Oulu University Hospital, FI-90220 Oulu, Finland., Kiemeney LA; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Knekt P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kovacs P; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Kraja AT; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Kumari M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.; Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK., Kuusisto J; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, FI-70211 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Marchand LL; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland., Lyssenko V; Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Marette A; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada., Matise TC; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., McKenzie CA; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., McKnight B; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Moll FL; Department of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Morris AP; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA., Nelis M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Madden PAF; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Pasterkamp G; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Peden JF; Illumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK., Peters A; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Postma DS; University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands., Pramstaller PP; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).; Department of Neurology, General Central Hospital, Bolzano 39100, Italy., Price JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Qi L; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Rao DC; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Rioux JD; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Université de Montréal, Montreal, Quebec H1T 1C8, Canada., Ritchie MD; Center for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA., Rudan I; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.; Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Saramies J; South Carelia Central Hospital, 53130 Lappeenranta, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Schunkert H; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Schwarz PEH; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), 01307 Dresden, Germany., Sever P; International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21201, USA., Sinisalo J; Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland., Stolk RP; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Tönjes A; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Trégouët DA; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France.; INSERM, UMR S 1166, Team Genomics and Physiopathology of Cardiovascular Diseases, F-75013 Paris, France.; Institute for Cardiometabolism And Nutrition (ICAN), F-75013 Paris, France., Tremblay A; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy., Virtamo J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Food Science and Nutrition, Laval University, Quebec QC G1V 0A6, Canada., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Waeber G; Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland., Willemsen G; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Witteman JC; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Zillikens MC; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Amouyel P; Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France., Asselbergs FW; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Assimes TL; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Bochud M; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Boehm BO; Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Boerwinkle E; Health Science Center at Houston, University of Texas, Houston, Texas 77030, USA., Bornstein SR; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Cauchi S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Chambers JC; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., de Bakker PIW; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Franks PW; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden., Froguel P; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Groop LC; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Hamsten A; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Hui J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.; School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia., Hunter DJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Hveem K; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Kaplan RC; Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Belfer 1306, New York 10461, USA., Kivimaki M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Laakso M; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.; Synlab Academy, Synlab Services GmbH, 68163 Mannheim, Germany., Melbye M; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.; Department of Clinical Medicine, Copenhagen University, 2200 Copenhagen, Denmark., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Munroe PB; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands.; Department of Clinical Genetics, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Perola M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Pérusse L; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Power C; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Quertermous T; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Rivadeneira F; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Saaristo TE; Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.; Pirkanmaa Hospital District, FI-33521 Tampere, Finland., Saleheen D; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Center for Non-Communicable Diseases, Karatchi, Pakistan.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10580, USA., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Slagboom PE; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Stumvoll M; 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Publikováno v: Nature [Nature] 2015 Feb 12; Vol. 518 (7538), pp. 197-206.

Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels.

Autor: Chernogubova E; Cardiovascular Genetics and Genomics Group, Center for Molecular Medicine, L8:02, Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden., Strawbridge R, Mahdessian H, Mälarstig A, Krapivner S, Gigante B, Hellénius ML, de Faire U, Franco-Cereceda A, Syvänen AC, Troutt JS, Konrad RJ, Eriksson P, Hamsten A, van 't Hooft FM

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2012 Jun; Vol. 32 (6), pp. 1526-34. Date of Electronic Publication: 2012 Mar 29.