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Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Autor: Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, J.P.P.M., Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J

Publikováno v: Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, van 't Hof, F N, Webb, T, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K, Smelser, D T, Crosslin, D R, de Andrade, M, Ryer, E J, McCarty, C A, Bottinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A, Bumpstead, S J, Badger, S A, Clough, R E, Cockerill, G W, Hafez, H, Scott, D J, Futers, T S, Romaine, S P, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, van Bockxmeer, F, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A, Wijmenga, C, de Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A E, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E, Björkegren, J L, Lipovich, L, Drolet, A M, Verhoeven, E, Zeebregts, C J, Geelkerken, R H, van Sambeek, M R, van Sterkenburg, S M, de Vries, J-P P, Stefansson, K, Thompson, J R, de Bakker, P I, Deloukas, P, Sayers, R D, Harrison, S, van Rij, A M, Samani, N J & Bown, M J 2016, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research . https://doi.org/10.1161/CIRCRESAHA.116.308765
Circulation Research
Circulation Research, 120(2), 341-353. Lippincott Williams and Wilkins
Circulation Research, 120(2), 341. Lippincott Williams and Wilkins
Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, van 't Hof, F N, Webb, T, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K, Smelser, D T, Crosslin, D R, de Andrade, M, Ryer, E J, McCarty, C A, Bottinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A, Bumpstead, S J, Badger, S A, Clough, R E, Cockerill, G W, Hafez, H, Scott, D J, Futers, T S, Romaine, S P, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, van Bockxmeer, F, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A, Wijmenga, C, de Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A E, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E, Björkegren, J L, Lipovich, L, Drolet, A M, Verhoeven, E, Zeebregts, C J, Geelkerken, R H, van Sambeek, M R, van Sterkenburg, S M, de Vries, J-P P, Stefansson, K, Thompson, J R, de Bakker, P I, Deloukas, P, Sayers, R D, Harrison, S, van Rij, A M, Samani, N J & Bown, M J 2017, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research, vol. 120, no. 2, pp. 341-353 . https://doi.org/10.1161/CIRCRESAHA.116.308765
Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, Van'T Hof, F N G, Webb, T R, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K M, Smelser, DI T, Crosslin, D R, De Andrade, M, Ryer, E J, McCarty, C A, Böttinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J A, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A R, Bumpstead, S, Badger, S A, Clough, R E, Cockerill, G, Hafez, H, Scott, D J A, Futers, T S, Romaine, S P R, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, Van Bockxmeer, F M, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A W, Wijmenga, C, De Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E E, Björkegren, J L M, Lipovich, L, Drolet, A M, Verhoeven, E L, Zeebregts, C J, Geelkerken, R H, Van Sambeek, M R, Van Sterkenburg, S M, De Vries, J P, Stefansson, K, Thompson, J R, De Bakker, P I W, Deloukas, P, Sayers, R D, Harrison, S C, Van Rij, A M, Samani, N J & Bown, M J 2017, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research, vol. 120, no. 2, pp. 341-353 . https://doi.org/10.1161/CIRCRESAHA.116.308765
Jones, G T, Tromp, G, Kuivaniemi, H, Gretarsdottir, S, Baas, A F, Giusti, B, Strauss, E, Van't Hof, F N G, Webb, T R, Erdman, R, Ritchie, M D, Elmore, J R, Verma, A, Pendergrass, S, Kullo, I J, Ye, Z, Peissig, P L, Gottesman, O, Verma, S S, Malinowski, J, Rasmussen-Torvik, L J, Borthwick, K M, Smelser, D T, Crosslin, D R, de Andrade, M, Ryer, E J, McCarty, C A, Böttinger, E P, Pacheco, J A, Crawford, D C, Carrell, D S, Gerhard, G S, Franklin, D P, Carey, D J, Phillips, V L, Williams, M J A, Wei, W, Blair, R, Hill, A A, Vasudevan, T M, Lewis, D R, Thomson, I A, Krysa, J, Hill, G B, Roake, J, Merriman, T R, Oszkinis, G, Galora, S, Saracini, C, Abbate, R, Pulli, R, Pratesi, C, Saratzis, A, Verissimo, A R, Bumpstead, S, Badger, S A, Clough, R E, Cockerill, G, Hafez, H, Scott, D J A, Futers, T S, Romaine, S P R, Bridge, K, Griffin, K J, Bailey, M A, Smith, A, Thompson, M M, van Bockxmeer, F M, Matthiasson, S E, Thorleifsson, G, Thorsteinsdottir, U, Blankensteijn, J D, Teijink, J A W, Wijmenga, C, de Graaf, J, Kiemeney, L A, Lindholt, J S, Hughes, A, Bradley, D T, Stirrups, K, Golledge, J, Norman, P E, Powell, J T, Humphries, S E, Hamby, S E, Goodall, A H, Nelson, C P, Sakalihasan, N, Courtois, A, Ferrell, R E, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Eicher, J D, Johnson, A D, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E E, Björkegren, J L M, Lipovich, L, Drolet, A M, Verhoeven, E L, Zeebregts, C J, Geelkerken, R H, van Sambeek, M R, van Sterkenburg, S M, de Vries, J P P M, Stefansson, K, Thompson, J R, de Bakker, P I W, Deloukas, P, Sayers, R D, Harrison, S C, van Rij, A M, Samani, N J & Bown, M J 2017, ' Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ', Circulation Research, vol. 120, no. 2, pp. 341-353 . https://doi.org/10.1161/CIRCRESAHA.116.308765

Supplemental Digital Content is available in the text.
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9765246dbee9fe88e574a6fb66b1fbdf
https://pure.qub.ac.uk/en/publications/28db45a5-0dcb-4669-93d7-d1bc1c916b0f

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms

Autor: Van't Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan [U.V.M.]

Background Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co‐occur, we hypothesized that there may be shared genetic r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e942f9784b4aab5cbeb829ce93510504