Výsledky vyhledávání - "vaginal microbicide"

Akademický článek

A Cationic Amphipathic Tilapia Piscidin 4 Peptide-Based Antimicrobial Formulation Promotes Eradication of Bacterial Vaginosis-Associated Bacterial Biofilms

Autor: Wen-Chun Lin, Yun-Ru Chen, Chi-Mu Chuang, Jyh-Yih Chen

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Bacterial vaginosis (BV) is prevalent among women of reproductive age and has a high rate of recurrence, which can be largely attributed to ineffective BV biofilm eradication by current first-line antibiotics. In this study, we report that the Nile t

Externí odkaz: https://doaj.org/article/2d26e0d2a2374294a2b234e7f2ecf18b

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Akademický článek

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Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection

Autor: Andrew N. Macintyre, Gregory D. Sempowski, Kristie L. Connolly, Ann E. Jerse, Allison C Costenoble-Caherty, Michelle Pilligua-Lucas, Knashka Underwood, Anthony Soc, Carolina Gomez

Publikováno v: J Infect Dis

Murine models of Neisseria gonorrhoeae lower reproductive tract infection are valuable systems for studying N. gonorrhoeae adaptation to the female host and immune responses to infection. These models have also accelerated preclinical testing of cand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801d8603052abce3fe40ed9f48d6d4b0
https://doi.org/10.1093/infdis/jiab211

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Nanotechnology-Based Platforms for Vaginal Delivery of Peptide Microbicides

Autor: Isabel Haro, Elena Sánchez-López, María J. Gómara

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Background: Vaginal drug delivery offers an opportunity for effective microbicide treatments. However, the physiological characteristics of the vagina represent a challenge when preparing microbicide formulations for local delivery that avoid systemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffc6afdbaeb3115547aff0847738acc
https://doi.org/10.2174/0929867328666201209095753

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Mucoadhesive Microspheres of Maraviroc and Tenofovir Designed for Pre-Exposure Prophylaxis of HIV-1: An in vitro Assessment of the Effect on Vaginal Lactic Acid Bacteria Microflora

Autor: Oliver Ezechi, O O Aina, Tajudeen A. Bamidele, Muinah A Fowora, C.I. Igwilo, C.P. Azubuike, Margaret O. Ilomuanya, Sabdat O. Ekama

Publikováno v: HIV/AIDS (Auckland, N.Z.)

Purpose To formulate and evaluate microspheres of the antiretroviral drugs maraviroc and tenofovir intended for a candidate vaginal microbicide and assess its effect on the vaginal lactic acid bacteria microflora. Methods Ionic gelation technique was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af1816df0e60b3abe4932414b21831e
https://doi.org/10.2147/hiv.s291065

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Assessment of risk compensation following use of the dapivirine vaginal ring in southwestern Uganda

Autor: Sylvia Kusemererwa, Martin Onyango, Joseph Mugisha, Anita Kabarambi, Andrew Abaasa

Publikováno v: Sexually Transmitted Infections

ObjectivesParticipation in HIV prevention trials could trigger risk compensation among participants. We evaluated potential risk compensation following use of a vaginal ring microbicide by women in a phase III trial in southwestern Uganda.MethodsWe u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca36be7c2fc6ed16bb83c2419422f63
https://doi.org/10.1136/sextrans-2020-054718

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The dapivirine vaginal ring from the perspective of married men in Uganda

Autor: Mitzy Gafos, Sylvia Kusemererwa, Philippe Mayaud, Emily A Krogstad, Joseph Mugisha, Anita Kabarambi, Janet Seeley

Publikováno v: African Journal of AIDS Research. 20:53-60

Background: Men play a key role in influencing uptake of women's health products, such as female condoms and vaginal microbicides used for family planning and HIV prevention.Method: We explored men's perceptions of the dapivirine vaginal ring (DVR),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf195ece4a3afacd5ff6c9009206afc3
https://doi.org/10.2989/16085906.2020.1866043

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Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium

Autor: Slawomir Wolczynski, Jakub Tomaszewski, Malgorzata Krzyzowska, Emilia Szymańska, Katarzyna Winnicka, Barbara Mikolaszek, Krzysztof Cal

Publikováno v: Drug Delivery, Vol 28, Iss 1, Pp 2278-2288 (2021)
Drug Delivery
article-version (VoR) Version of Record

Chitosan glutamate (gCS) spray-dried microparticles appear promising carriers to overcome challenges associated with vaginal microbicide delivery. This study aimed at elucidating the penetration and mucoadhesive behavior of developed gCS multiunit ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3461bd36b2155129d14c269782434bdb
https://doi.org/10.1080/10717544.2021.1992037

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Akademický článek

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Akademický článek

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