Zobrazeno 1 - 10
of 586
pro vyhledávání: '"urat1"'
Publikováno v:
Acta Materia Medica, Vol 3, Iss 3, Pp 345-348 (2024)
Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport. Using cryo-electro
Externí odkaz:
https://doaj.org/article/0a508a2ca28a4a77a5daae21b9e39266
Publikováno v:
Molecules, Vol 28, Iss 21, p 7415 (2023)
Urate transporter 1 (URAT1) is a clinically validated target for the treatment of hyperuricemia and gout. Due to the absence of protein structures, the molecular design of new URAT1 inhibitors generally resorts to ligand-based approaches. Two series
Externí odkaz:
https://doaj.org/article/a11c36f86e214955837e6c712be7f7a3
Publikováno v:
Clinical and Experimental Hypertension, Vol 43, Iss 8, Pp 730-741 (2021)
Background: Hyperuricemia is a risk factor for the development of hypertension and is comorbid in many hypertensive patients. According to Japanese hypertension management guidelines published in 2019, a target serum uric acid level of ≤6.0 mg/dL i
Externí odkaz:
https://doaj.org/article/5fcb29cb75814938aad68e4a2e7b7ed1
Akademický článek
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Akademický článek
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Publikováno v:
Drug Design, Development and Therapy, Vol Volume 15, Pp 3241-3254 (2021)
Qiaoping Li,1,* Ziwei Huang,2,* Defu Liu,3 Jingna Zheng,1 Jianhui Xie,4– 6 Jiannan Chen,1 Huifang Zeng,2 Ziren Su,1 Yucui Li1 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republ
Externí odkaz:
https://doaj.org/article/e60a4b816f214c6f8c5bf785706a1f6b
Publikováno v:
Childhood Kidney Diseases, Vol 25, Iss 1, Pp 44-48 (2021)
Idiopathic renal hypouricemia (iRHUC) is a rare hereditary disease caused by a defect in urate handling of renal tubules. Type 1 renal hypouricemia (RHUC1) is diagnosed with confirmation of a mutation in SLC22A12 gene which encodes a renal urate-anio
Externí odkaz:
https://doaj.org/article/e3279cd080d24c7bb5e849058bec4046
Autor:
Ana Perdomo-Ramirez, Elizabeth Cordoba-Lanus, Carmen Jane Trujillo-Frias, Carolina Gonzalez-Navasa, Elena Ramos-Trujillo, Maria Isabel Luis-Yanes, Victor Garcia-Nieto, Felix Claverie-Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8455 (2023)
Renal hypouricemia (RHUC) is a rare inherited disorder characterized by impaired urate reabsorption in the proximal tubule resulting in low urate serum levels and increased urate excretion. Some patients may present severe complications such as exerc
Externí odkaz:
https://doaj.org/article/4064d2edf06542178907c425851840cc
Autor:
Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Akira Yoshii, Haruka Kimura, Keiichi Ito, Yusuke Kashiwagi, Toshikazu D. Tanaka, Michihiro Yoshimura
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101411- (2022)
Objective: Accumulating evidence indicates that high uric acid (UA) is strongly associated with obesity and metabolic syndrome and drives the development of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Although urate transporter-1
Externí odkaz:
https://doaj.org/article/f1e6842c7e9248059338d41b569543c6
Autor:
Huining Dai, Shuai Lv, Zi'an Qiao, Kaiyu Wang, Xipeng Zhou, Chunyang Bao, Shitao Zhang, Xueqi Fu, Wannan Li
Publikováno v:
Frontiers in Nutrition, Vol 8 (2022)
The sunflower (Helianthus annuus L.) calathide is gradually used as an alternative treatment for hyperuricemia; nevertheless, evidence regarding its main components and therapeutic capacity for urate nephropathy is lacking. Identification of sunflowe
Externí odkaz:
https://doaj.org/article/85c2d7ccba184962ab4c1fec00cc99eb