Zobrazeno 1 - 10
of 80
pro vyhledávání: '"upper motor neurons"'
Autor:
Javier H. Jara, Mukesh Gautam, Nuran Kocak, Edward F. Xie, Qinwen Mao, Eileen H. Bigio, P. Hande Özdinler
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background The involvement of non-neuronal cells and the cells of innate immunity has been attributed to the initiation and progression of ALS. TDP-43 pathology is observed in a broad spectrum of ALS cases and is one of the most commonly sha
Externí odkaz:
https://doaj.org/article/4fb169a5f82540d09bc348b70cdffa81
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of both upper and lower motor neurons. Despite decades of research, we still to date lack a cure or disease modifying treatment, emphasizing the need for a much
Externí odkaz:
https://doaj.org/article/5d1befa82c8d436db44d311f83a917b1
Autor:
Javier H. Jara, Patrick L. Sheets, Maximiliano José Nigro, Mina Perić, Carolyn Brooks, Daniel B. Heller, Marco Martina, Pavle R. Andjus, P. Hande Ozdinler
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The brain is complex and heterogeneous. Even though numerous independent studies indicate cortical hyperexcitability as a potential contributor to amyotrophic lateral sclerosis (ALS) pathology, the mechanisms that are responsible for upper motor neur
Externí odkaz:
https://doaj.org/article/8edc9ade542c4cce8a4e59e8142721fd
Autor:
Zeynep I. Gunes, Vanessa W. Y. Kan, Shenyi Jiang, Evgeny Logunov, XiaoQian Ye, Sabine Liebscher
Publikováno v:
Clinical and Translational Neuroscience, Vol 6, Iss 1, p 5 (2022)
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by the degeneration of cortical and spinal motor neurons. With no effective treatment available to date, patients face progressive paralysis and eventually succumb to the disease du
Externí odkaz:
https://doaj.org/article/fc2c45e4b45c4bc2b6b3bb1f8998c869
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1112 (2021)
The selective degeneration of both upper motor neurons (UMNs) and lower motor neurons (LMNs) is the pathological hallmark of amyotrophic lateral sclerosis (ALS). Unlike the simple organisation of LMNs in the brainstem and spinal cord, UMNs are embedd
Externí odkaz:
https://doaj.org/article/fb61cabc67ed4d40924256d9224992a0
Autor:
Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos, Sandra Weintraub, M. Marsel Mesulam, Eileen H. Bigio, Richard J. Miller, P. Hande Özdinler
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-20 (2017)
Abstract Background Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC chemokine receptor 2)
Externí odkaz:
https://doaj.org/article/97c3d0e9ad8a4982a0dcf8b1afc51f08
Autor:
Courtney M. Clark, Rosemary M. Clark, Joshua A. Hoyle, Jyoti A. Chuckowree, Catriona A. McLean, Tracey C. Dickson
Publikováno v:
Brain Sciences, Vol 11, Iss 8, p 969 (2021)
Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While GABAergic inputs to upper motor neurons are reduced in models of the disease, less understood is th
Externí odkaz:
https://doaj.org/article/e24cf93696fb4f5e97b28aafb4c4edc3
Publikováno v:
Brain Sciences, Vol 11, Iss 5, p 578 (2021)
Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cor
Externí odkaz:
https://doaj.org/article/1adf1f94e64647c98c30ceb5f3da2b6c
Publikováno v:
Brain Sciences, Vol 11, Iss 3, p 369 (2021)
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease arising from the combined degeneration of upper motor neurons (UMN) in the motor cortex, and lower motor neurons (LMN) in the brainstem and spinal cord. This dua
Externí odkaz:
https://doaj.org/article/93db53e0b6864c3fbde7d3d58396af1b
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