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Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages

Autor: Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay, Andrew J. Mouland

Publikováno v: Retrovirology, Vol 16, Iss 1, Pp 1-15 (2019)

Abstract Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression. The role of the host mRNA decay

Externí odkaz: https://doaj.org/article/d2077e7aa6ca4dc5936756c42b995169

MicroRNA-1468 promotes tumor progression by activating PPAR-γ-mediated AKT signaling in human hepatocellular carcinoma

Autor: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu, Kangsheng Tu

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-14 (2018)

Abstract Background Accumulating evidence confirm that aberrant microRNAs (miRNAs) expression contributes to hepatocellular carcinoma (HCC) development and progression. Previous study reported that miR-1468 showed an up-regulated tendency and might b

Externí odkaz: https://doaj.org/article/16528734612d494295e3d580bb93924b

How cells kill a 'killer' messenger

Autor: Cosmin Saveanu, Alain Jacquier

Publikováno v: eLife, Vol 5 (2016)

Establishing a link between the nonsense-mediated decay pathway and a gene associated with programmed cell death could explain why this pathway is essential in most, but not all, eukaryotes.

Externí odkaz: https://doaj.org/article/2111917ac57947ebb9a30d29a4229010

Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1

Autor: Chandra S. Verma, Kamila Pawlicka, Douglas R. Houston, Monikaben Padariya, Javier A. Alfaro, Ted R. Hupp, Umesh Kalathiya

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 22, p 5644 (2019)
Kalathiya, U, Padariya, M, Pawlicka, K, Verma, C S, Houston, D, Hupp, T & Alfaro, J A 2019, ' Insights into the effects of cancer associated mutations at the UPF2 and ATP binding sites of NMD master regulator : UPF1 ', International Journal of Molecular Sciences . https://doi.org/10.3390/ijms20225644
International Journal of Molecular Sciences
Volume 20
Issue 22

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that recognizes post-transcriptionally abnormal transcripts and mediates their degradation. The master regulator of NMD is UPF1, an enzyme with intrinsic ATPase and helicase activities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc32c03cb90dacb1c98e4e7e20d14c5a
https://www.mdpi.com/1422-0067/20/22/5644