Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

Autor: Albert C. Ludolph, Petra Steinacker, Dietmar Rudolf Thal, Miriam Linsenmeier, Stefan Lehnert, Anja Schneider, Paul Walther, Markus Otto, Emily Feneberg

Publikováno v: Amyotrophic lateral sclerosis & frontotemporal degeneration 15(5-6), 351-356 (2014). doi:10.3109/21678421.2014.905606

TAR DNA-binding protein 43 (TDP-43) is one of the neuropathological hallmarks in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). It is present in patients' blood and cerebrospinal fluid (CSF); however, the source and

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https://doi.org/10.3109/21678421.2014.905606