Zobrazeno 1 - 10
of 13
pro vyhledávání: '"ultrastructure [Axons]"'
Autor:
Minou Djannatian, Swathi Radha, Ulrich Weikert, Shima Safaiyan, Christoph Wrede, Cassandra Deichsel, Georg Kislinger, Agata Rhomberg, Torben Ruhwedel, Douglas S. Campbell, Tjakko van Ham, Bettina Schmid, Jan Hegermann, Wiebke Möbius, Martina Schifferer, Mikael Simons
Publikováno v:
Journal of Cell Biology
The journal of cell biology 222(3), e202204010 (2023). doi:10.1083/jcb.202204010
The journal of cell biology 222(3), e202204010 (2023). doi:10.1083/jcb.202204010
To enable rapid propagation of action potentials, axons are ensheathed by myelin, a multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is generated early in development, resulting in the generation of long-lasting stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec3cb57c26854e853c7d9866f10fddc
https://hdl.handle.net/21.11116/0000-000C-AB1D-421.11116/0000-000C-AB1F-2
https://hdl.handle.net/21.11116/0000-000C-AB1D-421.11116/0000-000C-AB1F-2
Publikováno v:
Experimental neurology 317, 110-118 (2019). doi:10.1016/j.expneurol.2019.02.010
Axons in the adult mammalian brain and spinal cord fail to regenerate upon lesion. In vivo imaging serves as a tool to investigate the immediate response of axons to injury and how the same injured axons behave over time. Here, we describe the dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84757b2e2db66095b2416faf8305bd3
https://pubmed.ncbi.nlm.nih.gov/30794766
https://pubmed.ncbi.nlm.nih.gov/30794766
Publikováno v:
Nature protocols 14(4), 1235-1260 (2019). doi:10.1038/s41596-019-0140-z
Here we present a protocol for analyses of axon regeneration and density in unsectioned adult mouse spinal cord. This includes methods for injury and tracing of dorsal column sensory and corticospinal axons; clearing and staining of unsectioned spina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ce5e616ee0cc363abbba1806871069
https://pubmed.ncbi.nlm.nih.gov/30903109
https://pubmed.ncbi.nlm.nih.gov/30903109
Autor:
Stefanie, Schreiber, Grazyna, Debska-Vielhaber, Susanne, Abdulla, Judith, Machts, Frank, Schreiber, Siegfried, Kropf, Peter, KÖrtvelyessy, Sonja, KÖrner, Katja, Kollewe, Susanne, Petri, Reinhard, Dengler, Wolfram S, Kunz, Peter J, Nestor, Stefan, Vielhaber
Publikováno v:
Muscle & nerve 57(2), 273-278 (2017). doi:10.1002/mus.25682
We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7a92c49a027f611589ba98ef4a9592db
https://pub.dzne.de/record/139729
https://pub.dzne.de/record/139729
Autor:
Michele Curcio, Frank Bradke
Publikováno v:
Neuron 88(6), 1072-1074 (2015). doi:10.1016/j.neuron.2015.12.006
The microtubule cytoskeleton is a major determinant in neuronal polarity. In this issue of Neuron, van Beuningen et al. (2015) now report that TRIM46 forms parallel microtubule bundles in the proximal axon and reveal that it is crucial for the establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7052647a2f6a27060656ad1164967362
Autor:
Viktorija Velanac, Michael W. Sereda, Ruth M. Stassart, Dies Meijer, Markus H. Schwab, Bastian G. Brinkmann, Klaus-Armin Nave, Robert Fledrich
Publikováno v:
Nature Neuroscience; Vol 16
Nature reviews / Neuroscience 16(1), 48-54 (2012). doi:10.1038/nn.3281
Nature Neuroscience, 16(1), 48-U76. Nature Publishing Group
Nature reviews / Neuroscience 16(1), 48-54 (2012). doi:10.1038/nn.3281
Nature Neuroscience, 16(1), 48-U76. Nature Publishing Group
After peripheral nerve injury, axons regenerate and become remyelinated by resident Schwann cells. However, myelin repair never results in the original myelin thickness, suggesting insufficient stimulation by neuronal growth factors. Upon testing thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0176cddab12324d400af0426f4e98db9
Publikováno v:
Human molecular genetics 21(8), 1681-1692 (2011). doi:10.1093/hmg/ddr603
Human Molecular Genetics
Human Molecular Genetics
Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain. Our results indicate that neuronal migration was inhibited in mouse brains foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e259a742d8fb29fc6e53d8f4209a3d
https://doi.org/10.1093/hmg/ddr603
https://doi.org/10.1093/hmg/ddr603
Autor:
Catherine D. Sorbara, Bogdan-Nicolae Marincu, Thomas Misgeld, Christoph Mahler, Philip R. Williams, Martin Kerschensteiner, Adrian-Minh Schumacher, Oliver Griesbeck
Publikováno v:
Nature Communications 5(1), 5683 (2014). doi:10.1038/ncomms6683
Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961516ab5056536ec9e3bde9dbbc6df0
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002406 (2011)
PLoS Pathogens
PLoS pathogens 7(12), e1002406 (2011). doi:10.1371/journal.ppat.1002406
PLoS Pathogens
PLoS pathogens 7(12), e1002406 (2011). doi:10.1371/journal.ppat.1002406
During herpes simplex virus 1 (HSV1) egress in neurons, viral particles travel from the neuronal cell body along the axon towards the synapse. Whether HSV1 particles are transported as enveloped virions as proposed by the ‘married’ model or as no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18379f39fba692f4df41a3eadd900145
http://europepmc.org/articles/PMC3240593?pdf=render
http://europepmc.org/articles/PMC3240593?pdf=render
Publikováno v:
The EMBO journal 30(23), 4825-4837 (2011). doi:10.1038/emboj.2011.376
Embo Journal
Embo Journal
Missorting of Tau from axons to the somatodendritic compartment of neurons is a hallmark of Alzheimer's disease, but the mechanisms underlying normal sorting and pathological failure are poorly understood. Here, we used several Tau constructs labelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::deceb107b2b31e094a017fa7d727e5a0
https://pub.dzne.de/record/136362
https://pub.dzne.de/record/136362