Výsledky vyhledávání - "udc:615.4:54:615.015.8"

Discovery of a fragment hit compound targeting D-Ala

Autor: Proj, Matic, Hrast, Martina, Bajc, Gregor, dipl biol, Frlan, Rok, Meden, Anže, Butala, Matej, biokemik, Gobec, Stanislav

Publikováno v: Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 11, pp. 387-397, 2023.
Journal of enzyme inhibition and medicinal chemistry, str. 387-397 : Ilustr., Vol. 38, iss. 1, 2023
COBISS-ID: 22763225

Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::785471e52d8f9c46a5a6594fdb08ec69
https://repozitorij.uni-lj.si/Dokument.php?id=164549&dn=

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The structural features of novel bacterial topoisomerase inhibitors that define their activity on topoisomerase IV

Autor: Maja Kokot, Marko Anderluh, Martina Hrast, Nikola Minovski

Publikováno v: Journal of medicinal chemistry, vol. 65, no. 9, 2022.

The continued emergence of bacterial resistance has created an urgent need for new and effective antibacterial agents. Bacterial type II topoisomerases, such as DNA gyrase and topoisomerase IV (topoIV), are well-validated targets for antibacterial ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f1f38addb8c66101daba9d353640fa
https://repozitorij.uni-lj.si/Dokument.php?id=162061&dn=

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Hybrid inhibitors of DNA gyrase A and B

Autor: Durcik, Martina, Skok, Žiga, Ilaš, Janez, Zidar, Nace, Zega, Anamarija, Szili, Petra, Draskovits, Gábor, Revesz, T., Kikelj, Danijel, Nyerges, Ákos, Pál, Csaba, Peterlin-Mašič, Lucija, Tomašič, Tihomir

Publikováno v: Pharmaceutics, vol. 13, no. 1, 6, 2021.

The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3505::74e67012ba0d67e86a690c2e0f91e467
https://repozitorij.uni-lj.si/Dokument.php?id=153416&dn=

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Synthesis, in vitro antioxidant properties and distribution of a new cyanothiophene-based phenolic compound in olive oil-in-water emulsions

Autor: Luciano Saso, Janez Mravljak, Carlos Bravo-Díaz, Sonia Losada-Barreiro, Matej Sova

Publikováno v: Antioxidants
Investigo. Repositorio Institucional de la Universidade de Vigo
Universidade de Vigo (UVigo)
Antioxidants, vol. 9, no. 7, 623, 2020.
Antioxidants, Vol 9, Iss 623, p 623 (2020)
Volume 9
Issue 7

We synthesized and determined the antioxidant activity and distribution of a new cyanothiophene-based compound, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3,5-dihydroxybenzamide (SIM-53B), in intact stripped olive oil-in-water emulsion. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30303e8a16f8df2417825af11c657ad4
http://hdl.handle.net/11573/1461441

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