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Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy

Autor: Maja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Senerovic, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast

Publikováno v: European journal of medicinal chemistry, str. 1-13 : Ilustr., Vol. 250, 2023
COBISS-ID: 25429760
European journal of medicinal chemistry, vol. 115160, no. 250, pp. 1-13, 2023.

Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them struggle with the same issue -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007423b60ee74c7daa799df830c48ced
https://plus.cobiss.net/cobiss/si/en/bib/141418755

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Potential Drug-Drug Interactions among Patients with Schizophrenia Spectrum Disorders

Autor: Bačar, Cvetka, Nagode, Katja, farmacevtka, Pišlar, Mitja, Mrhar, Aleš, Grabnar, Iztok, Vovk, Tomaž

Publikováno v: Medicina, vol. 59, no. 2, 284, 2023.
Medicina, 13 str. : Ilustr., Vol. 59, iss. 2, art. 284, 2023
COBISS-ID: 6754623

Background and Objectives: Patients with schizophrenia are often exposed to polypharmacotherapy, which may lead to drug—drug interactions. The aim of the study was to investigate the prevalence of potential drug—drug interactions (pDDIs) in hospi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::94d158746079984cb7abc52bdda8d140
https://hdl.handle.net/20.500.12556/RUL-144168

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Načrtovanje zaviralcev katepsina K in avtolizina s pomočjo pristopov kemometrije in strukturno podprtega načrtovanja

Autor: Borišek, Jure

V raziskavah v sklopu doktorske disertacije smo se posvetili načrtovanju in eksperimentalnemu vrednotenju zaviralcev katepsina K (Cat K) in avtolizina E (AtlE). V prvem sklopu doktorskega dela smo preverili hipotezo, da s pomočjo opisa kemijske str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3505::0ed8b7c08bf8fd6049eae93b59ea8981
https://repozitorij.uni-lj.si/Dokument.php?id=165660&dn=

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Onkološki bolniki in cepljenje proti covid-19

Autor: Ivanuš, Urška, Batista, Kaja, Firanović, Tina, Duratović Konjević, Amela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3508::6651a1d644b5fcdcf22481d913bd8998
https://dirros.openscience.si/IzpisGradiva.php?id=15294

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A throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride has direct virucidal effect on SARS-CoV-2

Autor: Marko Kolenc, Miša Marušić, Andrej Steyer, Tina Triglav

Publikováno v: COVID, vol. 1, no. 2, pp. 435-446, 2021.
COVID
Volume 1
Issue 2
Pages 37-446

Viruses are the most common causative agents of inflammation in the oral cavity and throat region. Most respiratory tract infections are self-limiting and require no specific treatment. However, patients often use different self-medication therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08221402db89ce96186bc2c6b1dc7e0c
https://hdl.handle.net/20.500.12556/RUL-136324

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Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice

Autor: Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder

Publikováno v: Pharmaceuticals, 25 str. : Ilustr., Vol. 16, no. 1, art. 129, 2023
COBISS-ID: 517582617
Pharmaceuticals, vol. 16, no. 1, 129, 2023.
Pharmaceuticals; Volume 16; Issue 1; Pages: 129

Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f25bf6cca686dbca605e5739f53af2a
https://doi.org/10.3390/ph16010129

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Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice

Autor: Erika Cvetko, Maxine M. Kuroda, Vesna Mrak, Tatjana Stopar Pintaric, Liljana Markova, Simon Horvat, Admir Hadžić, Nejc Umek

Publikováno v: BMC veterinary research, vol. 16, 247, 2020.
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-8 (2020)
BMC Veterinary Research

Background Diabetes mellitus and the associated neuropathic complications have become a steadily increasing global health burden. Diabetic patients are estimated to require surgery at least twice as often as nondiabetic patients. Neuropathy may chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd94c1252c8c56c394f5e5a6185b0a81
https://repozitorij.uni-lj.si/Dokument.php?id=145646&dn=

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