Zobrazeno 1 - 10
of 5 238
pro vyhledávání: '"ubiquitylation"'
Publikováno v:
Cell Regeneration, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation. They are the substrate-recognition subunits of SKP1–cullin 1–F-box protein (SCF) E
Externí odkaz:
https://doaj.org/article/0a5198041935454e84ac4f8b2a0daa3f
Publikováno v:
Translational Oncology, Vol 45, Iss , Pp 101992- (2024)
CBLC (CBL proto-oncogene C) is an E3 ubiquitin protein ligase that plays a key role in cancers. However, the function and mechanism of CBLC in colorectal cancer (CRC) has not been fully elucidated. The aim of this study was to investigate the functio
Externí odkaz:
https://doaj.org/article/0c769ecdbbe54cdb8db9809a2b3e4f7e
Autor:
Xiaojian Zhu, Changxue Li, Yunfei Gao, Qingyuan Zhang, Tao Wang, Huaixiang Zhou, Fanqin Bu, Jia Chen, Xinjun Mao, Yulong He, Kaiming Wu, Ningning Li, Hongliang Luo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-21 (2024)
Abstract Background Chemoresistance presents a significant obstacle in the treatment of colorectal cancer (CRC), yet the molecular basis underlying CRC chemoresistance remains poorly understood, impeding the development of new therapeutic interventio
Externí odkaz:
https://doaj.org/article/3b7f6890472442379f21b27ed86ffa1c
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 10, p 357 (2024)
Background: Ubiquitination plays a key role in various cancers, and F-box and WD repeat domain containing 7 (FBW7) is a tumor suppressor that targets several cancer-causing proteins for ubiquitination. This paper set out to pinpoint the role of FBW7
Externí odkaz:
https://doaj.org/article/62d4642d124147649e358152418d8a27
Autor:
Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106421- (2024)
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43. A hurdle to the use of cyclin F, however, is that th
Externí odkaz:
https://doaj.org/article/938a323b072b422dbb397509b51afada
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Pulmonary hypertension (PH), an infrequent disease, is characterized by excessive pulmonary vascular remodeling and proliferation of pulmonary artery smooth muscle cells (PASMCs). However, its underlying molecular mechanisms remai
Externí odkaz:
https://doaj.org/article/79389e7e3c0b4883ba801590f73e996b
Autor:
Tobias Troost, Ekaterina Seib, Alina Airich, Nicole Vüllings, Aleksandar Necakov, Stefano De Renzis, Thomas Klein
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract Background Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be essential for the its signalling activity. Nevertheless, we
Externí odkaz:
https://doaj.org/article/9fca8440eb534bae9f46251419d5f760
Autor:
Dakui Luo, Min Chen, Qingguo Li, Kangjunjie Wang, Kaihua Wang, Junqiang Li, Guoxiang Fu, Zezhi Shan, Qi Liu, Yufei Yang, Lei Liang, Yanlei Ma, Yi Qin, Jun Qin, Daming Gao, Xinxiang Li
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-21 (2023)
Abstract Background UTX (encoded by KDM6A), a histone demethylase for H3K27me2/3, is frequently mutated in human cancers. However, its functional and regulatory mechanisms in colorectal cancer (CRC) remain unclear. Methods Immunohistochemistry staini
Externí odkaz:
https://doaj.org/article/8576dd92d49d41369206bcd4d1541e7a
Autor:
Zhitao Han, Qi Jia, Jing Zhang, Miaomiao Chen, Lining Wang, Kai Tong, Weiwei He, Yajie Zhang, Weina Zhu, Ju Qin, Tao Wang, Tielong Liu, Yong Ma, Yuanming Chen, Siluo Zha, Chunlei Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC). The publicly available TCGA database of breast
Externí odkaz:
https://doaj.org/article/c11fd26f31904be4a15a5c7ed6ba719d
Publikováno v:
Biology, Vol 13, Iss 4, p 233 (2024)
The eukaryotic replicative helicase (CMG complex) is assembled during DNA replication initiation in a highly regulated manner, which is described in depth by other manuscripts in this Issue. During DNA replication, the replicative helicase moves thro
Externí odkaz:
https://doaj.org/article/3cd5476b76014f9289bf922473c3813b