Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

Autor: Ina Hollerer, Juliet C. Barker, Victoria Jorgensen, Amy Tresenrider, Claire Dugast-Darzacq, Leon Y. Chan, Xavier Darzacq, Robert Tjian, Elçin Ünal, Gloria A. Brar

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 4, Pp 1045-1053 (2019)

We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference collaborate to down-regulate protein expression. Developmentally timed transcriptional interference inhibited pro

Externí odkaz: https://doaj.org/article/fbddfaee35014676a9c0c782a5c6f2d3

Kinetochore inactivation by expression of a repressive mRNA

Autor: Jingxun Chen, Amy Tresenrider, Minghao Chia, David T McSwiggen, Gianpiero Spedale, Victoria Jorgensen, Hanna Liao, Folkert Jacobus van Werven, Elçin Ünal

Publikováno v: eLife, Vol 6 (2017)

Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes. How the meiotic gene e

Externí odkaz: https://doaj.org/article/7480204f0f8649d9832e1dee6c5fdc69

Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

Autor: Ina Hollerer, Elçin Ünal, Gloria A. Brar, Leon Y. Chan, Claire Dugast-Darzacq, Robert Tjian, Xavier Darzacq, Amy Tresenrider, Juliet C Barker, Victoria Jorgensen

Publikováno v: G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 9, Iss 4, Pp 1045-1053 (2019)
G3 (Bethesda, Md.), vol 9, iss 4
Hollerer, Ina; Barker, Juliet C; Jorgensen, Victoria; Tresenrider, Amy; Dugast-Darzacq, Claire; Chan, Leon Y; et al.(2019). Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells.. G3 (Bethesda, Md.), g3.200802.2018-g3.200802.2018. doi: 10.1534/g3.118.200802. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4nq7v2gj

We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference were used in an integrated manner to down-regulate protein expression. Developmentally timed transcriptional inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9674ad984242d94e6721923954bb15c9

A Recurrent Germline Mutation in the 5'UTR of the Androgen Receptor Causes Complete Androgen Insensitivity by Activating Aberrant uORF Translation

Autor: Friederike Denzer, Nadine Hornig, Hans-Udo Schweikert, Olaf Hiort, Ralf Werner, Ole Ammerpohl, Alexandra Kulle, Reiner Siebert, Martine Cools, Martin Ukat, Laura Audí, Carine de Beaufort, Martin Wabitsch, Paul-Martin Holterhus

Publikováno v: PLoS ONE, 11(4). San Franscisco, CA: Public Library of Science (2016).
PLoS ONE, Vol 11, Iss 4, p e0154158 (2016)
PLOS ONE
PLoS ONE

A subset of patients with monogenic disorders lacks disease causing mutations in the protein coding region of the corresponding gene. Here we describe a recurrent germline mutation found in two unrelated patients with complete androgen insensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50e2933c1331ce3ffacdb7a20e7ad01
http://orbilu.uni.lu/handle/10993/27172

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