Zobrazeno 1 - 10
of 109
pro vyhledávání: '"type I IFN signaling"'
Autor:
Zhenfang Yan, Jingying Xie, Zhengyang Hou, Yaxin Zhang, Jiayu Yue, Xiangbo Zhang, Lei Chen, Yanmei Yang, Xiangrong Li, Huixia Li, Ruofei Feng
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Natural immunity is the first defense line of the host immune system, which plays a significant role in combating foreign pathogenic microorganisms. The IFN-β (interferon-beta) signaling pathway, being a typical example of innate immunity,
Externí odkaz:
https://doaj.org/article/5e46383ca2b24e3e97117213ec008fae
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Porcine reproductive and respiratory syndrome (PRRS) is an epidemic animal infectious disease worldwide, causing huge economic losses to the global swine industry. Fas-associated death domain (FADD) was previously reported to be an adaptor protein th
Externí odkaz:
https://doaj.org/article/2bc81eaed1d241c884a4a2053e9ac53e
Autor:
Qichao Chen, Liang Li, Lixinjie Liu, Zhankui Liu, Shibang Guo, Chen Tan, Huanchun Chen, Xiangru Wang
Publikováno v:
Virus Research, Vol 335, Iss , Pp 199190- (2023)
African swine fever virus (ASFV) is an extensive and intricate double-stranded DNA virus with approximately 100% lethality in domestic swine. There is no effective vaccine to combat this virus, and this has led to substantial economic losses in the s
Externí odkaz:
https://doaj.org/article/1517f60c08e7411699e0e77c0ac089f7
Autor:
Qichao Chen, Liang Li, Shibang Guo, Zhankui Liu, Lixinjie Liu, Chen Tan, Huanchun Chen, Xiangru Wang
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
This study evaluates the role of the late viral protein, pA104R, in African swine fever virus immunosuppression. ASFV-encoded pA104R is a putative histone-like protein that is highly conserved throughout different virulent and non-virulent isolates.
Externí odkaz:
https://doaj.org/article/4a3b0841740948a18ecab6f973f35df0
Akademický článek
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Autor:
Jiali Hu, Ruitao Lu, Yu Zhang, Wei Li, Qian Hu, Cuiyu Chen, Zhaoqian Liu, Wei Zhang, Ling Chen, Ran Xu, Jia Luo, Howard L. McLeod, Yijing He
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Background Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair the viral propagation in tumor cells. In this study, we explored the effect o
Externí odkaz:
https://doaj.org/article/e25fcc546df545339b2034d78d4652ad
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Over the last 2 years, several global virus-host interactome studies have been published with SARS-CoV-2 proteins with the purpose of better understanding how specific viral proteins can subvert or utilize different cellular processes to pro
Externí odkaz:
https://doaj.org/article/4194a5d8d8a346118e57f21f79a2e679
Autor:
Yujia Li, Min Yao, Xiaoqiong Duan, Haiyan Ye, Shilin Li, Limin Chen, Chunhui Yang, Yongjun Chen
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract Background Hepatitis B virus (HBV) infection remains as one of the major public health problems in the world. Type I interferon (IFN) plays an essential role in antiviral defense by induced expression of a few hundred interferon stimulated g
Externí odkaz:
https://doaj.org/article/02f37256776947b4871f75bb7a141f4e
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Viral infectious diseases pose a great challenge to human health around the world. Type I interferons (IFN-Is) function as the first line of host defense and thus play critical roles during virus infection by mediating the transcriptional induction o
Externí odkaz:
https://doaj.org/article/f041c91a33974640bfc5283bfa740969
Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway
Autor:
Carla Lima, Aline Ingrid Andrade-Barros, Jefferson Thiago Gonçalves Bernardo, Eniko Balogh, Valerie F. Quesniaux, Bernhard Ryffel, Monica Lopes-Ferreira
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3600 (2022)
Natterin is a potent pro-inflammatory fish molecule, inducing local and systemic IL-1β/IL-1R1-dependent neutrophilia mediated by non-canonical NLRP6 and NLRC4 inflammasome activation in mice, independent of NLRP3. In this work, we investigated wheth
Externí odkaz:
https://doaj.org/article/663b612f172d4d6a8fb8bb9152e3636d