Engaging stimulatory immune checkpoint interactions in the tumour immune microenvironment of primary liver cancers – how to push the gas after having released the brake

Autor: Yannick S. Rakké, Sonja I. Buschow, Jan N. M. IJzermans, Dave Sprengers

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the first and second most common primary liver cancer (PLC). For decades, systemic therapies consisting of tyrosine kinase inhibitors (TKIs) or chemotherapy have formed the cornerstone o

Externí odkaz: https://doaj.org/article/d7aa1a3be5864ca1bf2a74632baa3fa5

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COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study

Autor: Mervyn Singer, Nishkantha Arulkumaran, Timothy A C Snow, Cecilia Montanari, Rob Shulman, Alessia Longobardo

Publikováno v: Journal of Critical Care

Patients with COVID-19 ARDS have distinct physiological and immunological phenotypes compared to patients with non-COVID ARDS. Patients with COVID-19 ARDS (n = 32) had a significant improvement in PaO2: FiO2 ratio (p = 0.046) following low-dose stero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27fb2620f9e14229120b166f3545504

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

Autor: Christopher R. Paradise, Joanna S. Price, Gabriel L. Galea, Andre J. van Wijnen, Emily T. Camilleri, Gary S. Stein, Lance E. Lanyon, Amel Dudakovic, Lee B Meakin, Hanna Taipaleenmäki

Publikováno v: Gene: X
Galea, G L, Paradise, C R, Meakin, L B, Camilleri, E T, Taipaleenmaki, H, Stein, G S, Lanyon, L E, Price, J S, van Wijnen, A J & Dudakovic, A 2020, ' Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 ', Gene, vol. 763S, 100027, pp. 100027 . https://doi.org/10.1016/j.gene.2020.100027
Gene: X, Vol 5, Iss, Pp 100027-(2020)

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25bf36d9a55ee08ac308c9e986aaf2e
http://europepmc.org/articles/PMC7285908

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