Zobrazeno 1 - 10
of 645
pro vyhledávání: '"tumour immunity"'
Autor:
Vladan Milosevic, Arne Östman
Publikováno v:
Upsala Journal of Medical Sciences, Vol 129, Pp 1-12 (2024)
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population recognized as a key component of the tumour microenvironment (TME). Cancer-associated fibroblasts are known to play an important role in maintaining and remodelling the extracel
Externí odkaz:
https://doaj.org/article/49576ea65a9b4a4c971364719cff2b1b
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
Abstract Background The modification of N6‐methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptive immune systems through various pathways, including the regulation of messenger RNA. The YTH domain protein family, a
Externí odkaz:
https://doaj.org/article/95c982a41d3348a89e57f4f066279a9e
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-28 (2024)
Abstract T cells are fundamental components in tumour immunity and cancer immunotherapies, which have made immense strides and revolutionized cancer treatment paradigm. However, recent studies delineate the predicament of T cell dysregulation in tumo
Externí odkaz:
https://doaj.org/article/7d846df1b4ac4f3991ca2e27bf54b911
Autor:
Yuyuan Zhang, Mengjun Xu, Yuqing Ren, Yuhao Ba, Shutong Liu, Anning Zuo, Hui Xu, Siyuan Weng, Xinwei Han, Zaoqu Liu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an anti-tumour immune response in most cancer types, it has also
Externí odkaz:
https://doaj.org/article/b6254438b65f423a87197a106282fbd2
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Background Ovarian cancer (OC) is the most lethal gynecologic malignant tumour. The mechanism promoting OC initiation and progression remains unclear. SET domain bifurcated histone lysine methyltransferase 1(SETDB1) acts as an oncogene in a
Externí odkaz:
https://doaj.org/article/95df38d8f83046e6a035bf5c92ae295e
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
AbstractMacrophages play a crucial role in tumor initiation and progression, while macrophage-associated gene signature in colorectal cancer (CRC) patients has not been investigated. Our study aimed to identify macrophage-related molecular subgroups
Externí odkaz:
https://doaj.org/article/1fd27ff8078b4f9ba91691e4cd22c6ab
Autor:
Lihaoyun Huang, Haitao Li, Cangang Zhang, Quan Chen, Zaoqu Liu, Jian Zhang, Peng Luo, Ting Wei
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract As single‐cell RNA sequencing enables the detailed clustering of T‐cell subpopulations and facilitates the analysis of T‐cell metabolic states and metabolite dynamics, it has gained prominence as the preferred tool for understanding he
Externí odkaz:
https://doaj.org/article/8d994ec639da49faa21703fda8ba5de4
Autor:
Peter Cuthbertson, Amy Button, Chloe Sligar, Amal Elhage, Kara L. Vine, Debbie Watson, Ronald Sluyter
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1775 (2024)
Allogeneic haematopoietic stem cell transplantation (HSCT) leads to the establishment of graft-versus-leukaemia (GVL) immunity, but in many cases also results in the development of graft-versus-host disease (GVHD). This study aimed to determine if P2
Externí odkaz:
https://doaj.org/article/3c7d1049458c42d69a52adf21888b93e
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3333-3351 (2022)
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles i
Externí odkaz:
https://doaj.org/article/5b22375b885d41c5871cb7b6dc813e06
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