The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor

Autor: Yahui Wang, Ying Chu, Fenghua Cao, Zhihong Chen, Huaxi Xu, Shengjun Wang, Jie Ma

Publikováno v: Central European Journal of Immunology, Vol 47, Iss 4, Pp 373-381 (2023)

Triggering receptor expressed on myeloid cell-2 (TRE M2) is a transmembrane receptor which is specifically expressed on myeloid cells. To date, TRE M2 has been confirmed as a key factor in many pathologies, such as Alzheimer’s disease, obesity-rela

Externí odkaz: https://doaj.org/article/1e1ddb2b37e34fb781b350a1572be788

TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy

Autor: Kirsten De Ridder, Hanne Locy, Elisa Piccioni, Miren Ibarra Zuazo, Robin Maximilian Awad, Stefaan Verhulst, Mathias Van Bulck, Yannick De Vlaeminck, Quentin Lecocq, Eva Reijmen, Wout De Mey, Lien De Beck, Thomas Ertveldt, Isabel Pintelon, Jean-Pierre Timmermans, David Escors, Marleen Keyaerts, Karine Breckpot, Cleo Goyvaerts

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. Recent observations indicate a

Externí odkaz: https://doaj.org/article/8cb0f64de304414d9efd07fa0701e7a3

Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

Autor: Jianying Li, Chelsea Bolyard, Gang Xin, Zihai Li

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies. Targeting the mechanisms regulating myeloid cell function

Externí odkaz: https://doaj.org/article/fb486d9c832a40feb908444c779d2446

Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor

Autor: Tynisha S. Rafael, Hielke M. de Vries, Sarah R. Ottenhof, Ingrid Hofland, Annegien Broeks, Jeroen de Jong, Elise Bekers, Simon Horenblas, Renée X. de Menezes, Ekaterina S. Jordanova, Oscar R. Brouwer

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Comprehensive analysis of tumor infiltrating myeloid cells in the tumor microenvironment of penile squamous cell carcinoma (PSCC) is lacking. In this retrospective study, for the first time, PSCC resection specimens (N = 103) were annotated into the

Externí odkaz: https://doaj.org/article/840f2ad380fb4e11bde928d18f019202

Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor

Autor: Renée X. de Menezes, Ekaterina S. Jordanova, Elise Bekers, Hielke M. de Vries, Sarah R. Ottenhof, Jeroen de Jong, Tynisha S. Rafael, Oscar R. Brouwer, Simon Horenblas, Ingrid Hofland, Annegien Broeks

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Rafael, T S, de Vries, H M, Ottenhof, S R, Hofland, I, Broeks, A, de Jong, J, Bekers, E, Horenblas, S, de Menezes, R X, Jordanova, E S & Brouwer, O R 2021, ' Distinct Patterns of Myeloid Cell Infiltration in Patients With hrHPV-Positive and hrHPV-Negative Penile Squamous Cell Carcinoma: The Importance of Assessing Myeloid Cell Densities Within the Spatial Context of the Tumor ', Frontiers in Immunology, vol. 12, 682030, pp. 682030 . https://doi.org/10.3389/fimmu.2021.682030
Frontiers in Immunology, 12:682030

Comprehensive analysis of tumor infiltrating myeloid cells in the tumor microenvironment of penile squamous cell carcinoma (PSCC) is lacking. In this retrospective study, for the first time, PSCC resection specimens (N = 103) were annotated into the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c451c3b8d6ef1aef1ab0c6fa12323f4
https://doi.org/10.3389/fimmu.2021.682030