Zobrazeno 1 - 10
of 667
pro vyhledávání: '"tumor-infiltrating lymphocytes (tils)"'
Publikováno v:
Advanced Science, Vol 11, Iss 46, Pp n/a-n/a (2024)
Abstract Lung cancer remains the most prevalent malignant tumor worldwide and is the leading cause of cancer‐related mortality. Although immune checkpoint blockade has revolutionized the treatment of advanced lung cancer, many patients still do not
Externí odkaz:
https://doaj.org/article/1906cd43249c4b1199302ef5ae3f2c32
Autor:
Abu Bakr Azam, Felicia Wee, Juha P. Väyrynen, Willa Wen-You Yim, Yue Zhen Xue, Bok Leong Chua, Jeffrey Chun Tatt Lim, Aditya Chidambaram Somasundaram, Daniel Shao Weng Tan, Angela Takano, Chun Yuen Chow, Li Yan Khor, Tony Kiat Hon Lim, Joe Yeong, Mai Chan Lau, Yiyu Cai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDeep learning (DL) models predicting biomarker expression in images of hematoxylin and eosin (H&E)-stained tissues can improve access to multi-marker immunophenotyping, crucial for therapeutic monitoring, biomarker discovery, and personal
Externí odkaz:
https://doaj.org/article/101983bd690749259a72f6f849e2fb52
Autor:
Kjersti Sellæg, Ruth Schwienbacher, Mathias Kranz, Anna Engan Aamodt, Anna M. Wirsing, Gerd Berge, Elin Hadler-Olsen, Synnøve Norvoll Magnussen
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis. Tumor infiltrating lymphocytes (TILs) are associated with good prognosis i
Externí odkaz:
https://doaj.org/article/5f4d3a3ca9ea48a8868633d6ca5c36af
Autor:
Abdulmohammad Pezeshki, John C. Cheville, Angela B. Florio, Bradley C. Leibovich, George Vasmatzis
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundOnly 20 percent of renal and bladder cancer patients will show a significant response to immune checkpoint inhibitor (ICI) therapy, and no test currently available accurately predicts ICI response.MethodsWe developed an “immunotumoroid”
Externí odkaz:
https://doaj.org/article/7218c9713dc1428da8affaa6bf70d426
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
ObjectivesThe present study aimed to develop a radiomics nomogram based on conventional ultrasound (CUS) to preoperatively distinguish high tumor-infiltrating lymphocytes (TILs) and low TILs in triple-negative breast cancer (TNBC) patients.MethodsIn
Externí odkaz:
https://doaj.org/article/ca80be4e863a44d0a9f38c79edec1ebf
Autor:
Zoran Gatalica, Nataliya Kuzmova, Inga Rose, Monika Ulamec, Melita Peric-Balja, Faruk Skenderi, Semir Vranic
Publikováno v:
Biomolecules & Biomedicine, Vol 24, Iss 2 (2024)
In the current study, we assessed the prevalence and molecular features of HER2-low phenotype in the apocrine carcinomas of the breast (ApoCa) and its relationship with tumor-infiltrating lymphocytes (TILs). A cohort of 64 well-characterized therapy-
Externí odkaz:
https://doaj.org/article/98174daa0c0d48888a0eeaa67441e2af
Autor:
Xiang Wang, Zijun Yuan, Zhengbo Li, Xinyu He, Yinping Zhang, Xingyue Wang, Jiahong Su, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Yueshui Zhao, Jing Shen, Tao Yi, Zhangang Xiao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The incidence of hepatocellular carcinoma (HCC) ranks first among primary liver cancers, and its mortality rate exhibits a consistent annual increase. The treatment of HCC has witnessed a significant surge in recent years, with the emergence of targe
Externí odkaz:
https://doaj.org/article/c80dd779a6ee4d84a1bde245d4362c20
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 3, Pp 151-164 (2023)
Abstract CD47 expressed on tumor cells binds to signal regulatory protein alpha on macrophages, initiating inhibition of phagocytosis. We investigated the relationships between tumor expression of CD47 and CD68 macrophage content, subsets of tumor‐
Externí odkaz:
https://doaj.org/article/91b86216cd7f482a880dd6492a71a0b6
Autor:
Chiara Brachelente, Filippo Torrigiani, Ilaria Porcellato, Michele Drigo, Martina Brescia, Elisabetta Treggiari, Silvia Ferro, Valentina Zappulli, Monica Sforna
Publikováno v:
Animals, Vol 14, Iss 8, p 1224 (2024)
Tumor cells can induce important cellular and molecular modifications in the tissue or host where they grow. The idea that the host and tumor interact with each other has led to the concept of a tumor microenvironment, composed of immune cells, strom
Externí odkaz:
https://doaj.org/article/ab682e9ea8284d81b96e20ab7ccb7883
Autor:
Guan-Hua Su, Yi Xiao, Lin Jiang, Ren-Cheng Zheng, He Wang, Yan Chen, Ya-Jia Gu, Chao You, Zhi-Ming Shao
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Tumor-infiltrating lymphocytes (TILs) have become a promising biomarker for assessing tumor immune microenvironment and predicting immunotherapy response. However, the assessment of TILs relies on invasive pathological slides. Met
Externí odkaz:
https://doaj.org/article/650dd5365e3543a4ac58eb4473bbd130