Zobrazeno 1 - 10
of 2 028
pro vyhledávání: '"tumor-associated antigens"'
Autor:
Changlin Yang, Vrunda Trivedi, Kyle Dyson, Tongjun Gu, Kate M. Candelario, Oleg Yegorov, Duane A. Mitchell
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account. Newer, safer, patient-specific treatment approaches are required to treat high-risk medulloblastom
Externí odkaz:
https://doaj.org/article/8684278dd84441a8814e938fc4589449
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2361-2377 (2024)
T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens, thereby engaging with CD3 on the T cell receptor. This linkage between tumor cells and T cells actively triggers T cell activation and initiates
Externí odkaz:
https://doaj.org/article/b5df7d48427c435599d3d70f4b830d2f
Autor:
Yifan Cheng, Qing Li, Guiying Sun, Tiandong Li, Yuanlin Zou, Hua Ye, Keyan Wang, Jianxiang Shi, Peng Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The purpose of this study was to identify novel autoantibodies against tumor-associated antigens (TAAs) and explore a diagnostic panel for Ovarian cancer (OC). Enzyme-linked immunosorbent assay was used to detect the expression of five anti-
Externí odkaz:
https://doaj.org/article/c20ce9aca0b44a569c1445451da4792d
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint. Defect in one or more of these mechanisms causes additive
Externí odkaz:
https://doaj.org/article/fbff5259b984451397a31a559e3f4eac
Autor:
Silvia Brugiapaglia, Sara Bulfamante, Claudia Curcio, Maddalena Arigoni, Raffaele Calogero, Lisa Bonello, Elisa Genuardi, Rosella Spadi, Maria Antonietta Satolli, Donata Campra, Daniele Giordano, Paola Cappello, Francesca Cordero, Francesco Novelli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPancreatic Ductal Adenocarcinoma (PDA) is one of the most aggressive malignancies with a 5-year survival rate of 13%. Less than 20% of patients have a resectable tumor at diagnosis due to the lack of distinctive symptoms and reliable biom
Externí odkaz:
https://doaj.org/article/76a09af1172e4c0f8aa82fe17684894b
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/ca24dd89f8ba4051bf9e01d17f505417
Autor:
Zhen Xu, Ze-Xiu Xiao, Jing Wang, Hao-Wei Qiu, Fei Cao, Shi-Qiang Zhang, Yuan-Dong Xu, Han-Qi Lei, Heng Xia, Yun-Ru He, Gao-Feng Zha, Jun Pang
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Prostate cancer (PCa) is characterized as a “cold tumor” with limited immune responses, rendering the tumor resistant to immune checkpoint inhibitors (ICI). Therapeutic messenger RNA (mRNA) vaccines have emerged as a promising strategy to overcom
Externí odkaz:
https://doaj.org/article/cbd29fbd3fa84d29b98360b4a443d88f
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101651- (2024)
Background: Melanoma is the most fatal kind of skin cancer. Among its various types, cutaneous melanoma is the most prevalent one. Melanoma cells are thought to be highly immunogenic due to the presence of distinct tumor-associated antigens (TAAs), w
Externí odkaz:
https://doaj.org/article/b2d55fe2a1bb46b9899dd29a2c2a5998
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Identification of promising targeted antigens that exhibited cancer-specific expression is a crucial step in the development of novel antibody-targeted therapies. We here aimed to investigate the anti-tumor activity of a novel mon
Externí odkaz:
https://doaj.org/article/c7170e3734904acb9ae5d7abb68d3078
Autor:
Jieun Han, Jaesung Lim, Chi-Pin James Wang, Jun-Hyeok Han, Ha Eun Shin, Se-Na Kim, Dooyong Jeong, Sang Hwi Lee, Bok-Hwan Chun, Chun Gwon Park, Wooram Park
Publikováno v:
Nano Convergence, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Cancer immunotherapy, which harnesses the power of the immune system, has shown immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a versatile instrument in this context, with its capacity to encode tumor-assoc
Externí odkaz:
https://doaj.org/article/0ea85ac5301c4462b11f7e4999d9a69f