Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo

Autor: Thierry Michy, Claire Bernard, Véronique Josserand, Thibault Massias, And Amandine Hurbin, Isabelle Texier, Maxime Henry, Mélanie Guidetti, Guy Royal, Jean-Luc Coll, Laetitia Vanwonterghem

Publikováno v: Cancers
Cancers, MDPI, 2019, ⟨10.3390/cancers11111760⟩
Cancers, Vol 11, Iss 11, p 1760 (2019)
Volume 11
Issue 11
Cancers, 2019, ⟨10.3390/cancers11111760⟩

Advanced ovarian cancer is the most lethal gynecological cancer, with a high rate of chemoresistance and relapse. Photodynamic therapy offers new prospects for ovarian cancer treatment, but current photosensitizers lack tumor specificity, resulting i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b7d4b8ed6df720cd1bd8047c94dcd0
https://hal.archives-ouvertes.fr/hal-02373996

Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect

Autor: Olivier Loréal, Martine Ropert, François Gaboriau, Sylvie Lepage, Vincent Corcé, Isabelle Cannie, David Deniaud, Stéphanie Renaud

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩
Biochemical Pharmacology, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩

International audience; Tumor cell growth requires large iron quantities and the deprivation of this metal induced by synthetic metal chelators is therefore an attractive method for limiting the cancer cell proliferation. The antiproliferative effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8eaeacdc2a079dd88d9dcdf99544b
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163245/document