Zobrazeno 1 - 10
of 1 788
pro vyhledávání: '"tumor suppressors"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
PHD (plant homeodomain) finger proteins emerge as central epigenetic readers and modulators in cancer biology, orchestrating a broad spectrum of cellular processes pivotal to oncogenesis and tumor suppression. This review delineates the dualistic rol
Externí odkaz:
https://doaj.org/article/22c578ba8f0b41968c90d0d53bc804fd
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 846 (2024)
Tumors developed in immunocompromised hosts are more immunogenic. However, few studies have addressed the potential mechanisms underlying the high immunogenicity of tumors found in a suppressed immune system. Therefore, we aimed to elucidate the impa
Externí odkaz:
https://doaj.org/article/23e5744c810448a4b0f3c3ce40b038b9
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-33 (2023)
Abstract Background Targeting the epigenome of cancerous diseases represents an innovative approach, and the DNA methylation inhibitor decitabine is recommended for the treatment of hematological malignancies. Although epigenetic alterations are also
Externí odkaz:
https://doaj.org/article/77be43e9779a4f618ea8b92f09775757
Autor:
Sanjay K. Singh, Yan Wang, Ahmed Habib, Mamindla Priyadarshini, Chowdari V. Kodavali, Apeng Chen, Wencai Ma, Jing Wang, N. U. Farrukh Hameed, Baoli Hu, Gregory N. Fuller, Scott M. Kulich, Nduka Amankulor, Rivka R. Colen, Lincoln A. Edwards, Pascal O. Zinn
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources. This limitation slows down progress in both drug discovery and patient su
Externí odkaz:
https://doaj.org/article/14b70cbfdcae49adb6619b89be2df058
Autor:
Wenyong Zhu, Hao Huang, Wenlong Ming, Rongxin Zhang, Yu Gu, Yunfei Bai, Xiaoan Liu, Hongde Liu, Yun Liu, Wanjun Gu, Xiao Sun
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4432-4445 (2023)
Highly transcribed noncoding elements (HTNEs) are critical noncoding elements with high levels of transcriptional capacity in particular cohorts involved in multiple cellular biological processes. Investigation of HTNEs with persistent aberrant expre
Externí odkaz:
https://doaj.org/article/6bc367f4b1ff46fe80e2a011310ab2b5
Publikováno v:
Cancers, Vol 16, Iss 4, p 805 (2024)
Prostate cancer (PC) is a common malignancy among elderly men, characterized by great heterogeneity in its clinical course, ranging from an indolent to a highly aggressive disease. The aggressive variant of prostate cancer (AVPC) clinically shows an
Externí odkaz:
https://doaj.org/article/fd46e2604dc548ea9a1877981953e457
Akademický článek
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Autor:
Hae Ryung Chang
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2527 (2023)
Ubiquitination is a post-translational modification (PTM) that is involved in proteolysis, protein–protein interaction, and signal transduction. Accumulation of mutations and genomic instability are characteristic of cancer cells, and dysfunction o
Externí odkaz:
https://doaj.org/article/6a867d78b81b48e0869ba61bdab196d2