Výsledky vyhledávání - "tumor necrosis factor receptor associated factor 2"

IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Autor: Marta Acchioni, Anna Lisa Remoli, Angela Battistini, Robert Clarke, Chiara Acchioni, Giulia Marsili, Roberto Orsatti, Edvige Perrotti, Marco Sgarbanti

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 459-469 (2020)
Neoplasia (New York, N.Y.)

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dc31ce8201d10ab9e5e10769229024
http://www.sciencedirect.com/science/article/pii/S1476558620301354

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Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury

Autor: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences

Testicular torsion and detorsion (TTD) is a serious urological condition affecting young males that is underlined by an ischemia reperfusion injury (tIRI) to the testis as the pathophysiological mechanism. During tIRI, uncontrolled production of oxyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69
http://www.sciencedirect.com/science/article/pii/S1319562X20301364

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Akademický článek

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Proinflammatory Cytokines Are Soluble Mediators Linked with Ventricular Arrhythmias and Contractile Dysfunction in a Rat Model of Metabolic Syndrome

Autor: César Rodríguez-Rodríguez, Niria Treviño-Saldaña, Alejandro Torres-Quintanilla, Karla Carvajal, Noemí García, Elena C. Castillo, B. Cicero Willis, Gerardo García-Rivas, Erasmo De la Peña, Evaristo Fernández-Sada, Yuriana Oropeza-Almazán, Christian Silva-Platas, Judith Bernal-Ramírez, Leticia Elizondo-Montemayor

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)

Metabolic syndrome (MS) increases cardiovascular risk and is associated with cardiac dysfunction and arrhythmias, although the precise mechanisms are still under study. Chronic inflammation in MS has emerged as a possible cause of adverse cardiac eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdcc4af30627e096c6aebf84d7a4db4
https://doi.org/10.1155/2017/7682569

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TRAF2 and FKBP51 as possible markers for identification of suitable melanoma tumors for tumor necrosis factor-α inhibition

Autor: Stefania Staibano, Maria Fiammetta Romano, Martina Tufano, Gennaro Ilardi, Anna Rea, Paolo D'Arrigo, Francesco Merolla, Simona Romano, Antonello Petrella

Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine, whose role in melanoma is controversial. Although high-dose TNF-α is approved for the treatment of patients with in transit-metastatic melanoma confined to the limb, diverse preclinical mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5688bd080b51440d32167235cb64bb3
http://hdl.handle.net/11386/4719017

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Akademický článek

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Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change

Autor: Kazuhiro Sakamaki, Chisa Shukunami, Kentaro Tomii, Naoto Ueno, Hiroaki Iwata, Kumiko Chiba, Chiyo Takagi, Kenichiro Imai, Naoyuki Iwabe

Publikováno v: Biochemistry and Biophysics Reports

Cellular FLICE-like inhibitory protein (c-FLIP, gene symbol CFLAR) was first identified as a negative regulator of death receptor-mediated apoptosis in mammals. To understand the ubiquity and diversity of the c-FLIP protein subfamily during evolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1affca1a95815da2e31ef14cbfe098c1
http://hdl.handle.net/2433/199933

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Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

Autor: Marco Corazzari, Mauro Piacentini, Mara Gagliardi, Gian Maria Fimia

Publikováno v: Frontiers in Oncology, Vol 7 (2017)
Frontiers in Oncology

Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed ‘ER stress’ determining the activation of a finely regulated program defined as Unfolded Protein Response (UPR) and whose primary aim is to restore this o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7420069ef35161d02bd32520ed2904d3
http://journal.frontiersin.org/article/10.3389/fonc.2017.00078/full

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