Zobrazeno 1 - 10
of 2 705
pro vyhledávání: '"tumor mutational burden"'
Autor:
Gaohua Li, Tingting Wu, Heping Li, Chuzhong Wei, Yuanbo Sun, Pengcheng Gao, Xinlin Huang, Zining Liu, Jianwei Li, Yanan Wang, Guoxin Li, Lei Fan
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Skin cutaneous melanoma (SKCM) poses a significant public health challenge due to its aggressive nature and limited treatment options. To address this, the study introduces the Tumor Mutational Burden-Derived Immune lncRNA Prognos
Externí odkaz:
https://doaj.org/article/05e4998bbbaa49758cc64ac14a381fc1
Autor:
Yoshiko Mori, Okihide Suzuki, Noriko Tanabe, Aoi Sugino, Takehiro Shiraishi, Norimichi Chiyonobu, Kenichi Chikatani, Noriyasu Chika, Satoshi Hatano, Takatoshi Matsuyama, Keiichiro Ishibashi, Hideyuki Ishida
Publikováno v:
Journal of the Anus, Rectum and Colon, Vol 8, Iss 4, Pp 289-297 (2024)
Objectives: Although some studies have evaluated the effectiveness of comprehensive genomic profiling (CGP) in solid tumors, the effectiveness of CGP in metastatic colorectal cancer (mCRC) has not been evaluated using detailed real-world long-outcome
Externí odkaz:
https://doaj.org/article/c07ff7079e574fd788b4a0358c9bde11
Autor:
Olga Kim, Zach Sergi, Guangyang Yu, Kazutoshi Yamamoto, Martha Quezado, Zied Abdullaev, Danel R. Crooks, Shun Kishimoto, Qi Li, Peng Lu, Burchelle Blackman, Thorkell Andresson, Xiaolin Wu, Bao Tran, Jun S. Wei, Wei Zhang, Meili Zhang, Hua Song, Javed Khan, Murali C. Krishna, Jeffrey R. Brender, Jing Wu
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Malignant transformation (MT) is commonly seen in IDH-mutant gliomas. There has been a growing research interest in revealing its underlying mechanisms and intervening prior to MT at the early stages of the transforming process. Here we esta
Externí odkaz:
https://doaj.org/article/4b329e13fa87456ea2628bbe4d0bfe40
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The calcium-binding protein S100A9 has emerged as a pivotal biomolecular actor in oncology, implicated in numerous malignancies. This comprehensive bioinformatics study transcends traditional boundaries, investigating the prognostic and ther
Externí odkaz:
https://doaj.org/article/3ac1f95acf1d4954ad8dd6a74d79c838
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Inflammation plays a critical role in tumor development. Inflammatory cell infiltration and inflammatory mediator synthesis cause changes in the tumor microenvironment (TME) in several cancers, especially in intrahepatic cholangio
Externí odkaz:
https://doaj.org/article/a2185fd3283444bfb97f799e7c194af3
Autor:
Hiroshi Katoh, Tomoya Mitsuma, Riku Okamoto, Kanako Naito, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai
Publikováno v:
Endocrine Journal, Vol 71, Iss 11, Pp 1069-1075 (2024)
Parathyroid cancer (PC) is extremely resistant to chemotherapy and radiotherapy (RT), but hormonally functional by producing excessive parathyroid hormone (PTH), causing remarkable hypercalcemia even in biochemical disease recurrence. Accordingly, ma
Externí odkaz:
https://doaj.org/article/657c14e8ac0c499bbf8c479bfcd83a88
Publikováno v:
Chinese Journal of Lung Cancer, Vol 27, Iss 6, Pp 459-465 (2024)
Lung cancer is one of the most common malignant tumors in the world, of which non-small cell lung cancer (NSCLC) is the majority. The emergence of immune checkpoint inhibitors (ICIs) has greatly changed the treatment strategy of NSCLC and improved th
Externí odkaz:
https://doaj.org/article/1f1ffd5231c046759d1f941742082a09
Autor:
Yu Wang, Wenqing Wang, Tao Zhang, Yin Yang, Jianyang Wang, Canjun Li, Xin Xu, Yuqi Wu, Ying Jiang, Jinghao Duan, Luhua Wang, Nan Bi
Publikováno v:
Journal of the National Cancer Center, Vol 4, Iss 2, Pp 177-187 (2024)
Background: Liquid biopsy-based biomarkers, including circulating tumor DNA (ctDNA) and blood tumor mutational burden (bTMB), are recognized as promising predictors of prognoses and responses to immune checkpoint inhibitors (ICIs), despite insufficie
Externí odkaz:
https://doaj.org/article/963f4f9165474b94b0a8daddc649c28d
Autor:
Chunyan Lan, Huaiwu Lu, Lin Zhou, Kunlun Liao, Junxiu Liu, Zhiwen Xie, Haixi Liang, Guorong Zou, Ting Yang, Qin Xu, Xin Huang
Publikováno v:
Cancer Communications, Vol 44, Iss 6, Pp 654-669 (2024)
Abstract Background Camrelizumab plus apatinib have demonstrated robust antitumor activity and safety in patients with advanced cervical cancer (CLAP study; NCT03816553). We herein present the updated long‐term results of the CLAP study and explore
Externí odkaz:
https://doaj.org/article/0e9447bc32f74ee488112a4283effb55
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Backgrounds Microfibril-associated protein 2 (MFAP2) is a protein presenting in the extracellular matrix that governs the activity of microfibrils through its interaction with fibrillin. While the involvement of MFAP2 in metabolic disorders
Externí odkaz:
https://doaj.org/article/9b1873c6a0364e79848fd23a686e88b8