Zobrazeno 1 - 10
of 383
pro vyhledávání: '"tullio pozzan"'
Autor:
Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity
Externí odkaz:
https://doaj.org/article/2692d4385d9d452f9a4c2132e63f0f7d
Autor:
Elisa Greotti, Ilaria Fortunati, Diana Pendin, Camilla Ferrante, Luisa Galla, Lorena Zentilin, Mauro Giacca, Nina Kaludercic, Moises Di Sante, Letizia Mariotti, Annamaria Lia, Marta Gómez-Gonzalo, Michele Sessolo, Giorgio Carmignoto, Renato Bozio, Tullio Pozzan
Publikováno v:
iScience, Vol 16, Iss , Pp 340-355 (2019)
Summary: Genetically Encoded Ca2+ Indicators (GECIs) are extensively used to study organelle Ca2+ homeostasis, although some available probes are still plagued by a number of problems, e.g., low fluorescence intensity, partial mistargeting, and pH se
Externí odkaz:
https://doaj.org/article/68a895b0109142569ddc88129249e310
Autor:
Elisa Greotti, Tullio Pozzan
Publikováno v:
Bio-Protocol, Vol 10, Iss 3 (2020)
Calcium (Ca2+) imaging aims at investigating the dynamic changes in live cells of its concentration ([Ca2+]) in different pathophysiological conditions. Ca2+ is an ubiquitous and versatile intracellular signal that modulates a large variety of cellul
Externí odkaz:
https://doaj.org/article/62c1d00cc85d4369adab79d9bb44d621
Autor:
Alessandro Leparulo, Marta Bisio, Nelly Redolfi, Tullio Pozzan, Stefano Vassanelli, Cristina Fasolato
Publikováno v:
Cells, Vol 11, Iss 2, p 238 (2022)
For Alzheimer’s disease (AD), aging is the main risk factor, but whether cognitive impairments due to aging resemble early AD deficits is not yet defined. When working with mouse models of AD, the situation is just as complicated, because only a fe
Externí odkaz:
https://doaj.org/article/7a496efd4ed64a2098cf7bb6e15fc89f
Publikováno v:
Cells, Vol 10, Iss 8, p 2046 (2021)
In Alzheimer’s disease (AD), the molecular mechanisms involved in the neurodegeneration are still incompletely defined, though this aspect is crucial for a better understanding of the malady and for devising effective therapies. Mitochondrial dysfu
Externí odkaz:
https://doaj.org/article/82d4811629a0468aa74f31970f0431ff
Autor:
Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, Paola Pizzo
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2226-2238 (2016)
Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes.
Externí odkaz:
https://doaj.org/article/2949ced184f94370b7ddf6757664b549
Autor:
Alice Rossi, Luisa Galla, Chiara Gomiero, Lorena Zentilin, Mauro Giacca, Valentina Giorgio, Tito Calì, Tullio Pozzan, Elisa Greotti, Paola Pizzo
Publikováno v:
Cells, Vol 10, Iss 2, p 204 (2021)
Alzheimer′s disease (AD) is the most common age-related neurodegenerative disorder in which learning, memory and cognitive functions decline progressively. Familial forms of AD (FAD) are caused by mutations in amyloid precursor protein (APP), prese
Externí odkaz:
https://doaj.org/article/64c87adde9e44832bde17315e88c959e
Autor:
Paola Pizzo, Emy Basso, Riccardo Filadi, Elisa Greotti, Alessandro Leparulo, Diana Pendin, Nelly Redolfi, Michela Rossini, Nicola Vajente, Tullio Pozzan, Cristina Fasolato
Publikováno v:
Cells, Vol 9, Iss 10, p 2166 (2020)
Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimate
Externí odkaz:
https://doaj.org/article/77b7dcffd7784e8b81cd1a266393c925
Autor:
Alessandro Leparulo, Mufti Mahmud, Elena Scremin, Tullio Pozzan, Stefano Vassanelli, Cristina Fasolato
Publikováno v:
Cells, Vol 9, Iss 1, p 54 (2019)
To fight Alzheimer’s disease (AD), we should know when, where, and how brain network dysfunctions initiate. In AD mouse models, relevant information can be derived from brain electrical activity. With a multi-site linear probe, we recorded local fi
Externí odkaz:
https://doaj.org/article/3d96b84dac3d494bb2a69e5a852793a0
Autor:
Stefano D’Errico, Emy Basso, Andrea Patrizia Falanga, Maria Marzano, Tullio Pozzan, Vincenzo Piccialli, Gennaro Piccialli, Giorgia Oliviero, Nicola Borbone
Publikováno v:
Marine Drugs, Vol 17, Iss 8, p 476 (2019)
Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca2+ mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts
Externí odkaz:
https://doaj.org/article/34d2ce62e3cf4085aa475a1f333130b3