First total synthesis, antitumor evaluation and target identification of mornaphthoate E: A new tubulin inhibitor template acting on PI3K/Akt signaling pathway

Autor: Peipei Shan, Tao Ye, Ying-De Tang, Hui Song, Chao Wang, Kongkai Zhu, Feifei Yang, Shi-Lei Zhang, Pei-Wen Su, Shuanhu Gao, Hua Zhang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2177-2193 (2024)

Mornaphthoate E (MPE) is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remarkable cytotoxicity against several human tumor cell lines. In the current project, the fi

Externí odkaz: https://doaj.org/article/756d1a49160f44f6835196b9c5c560cc

Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer.

Autor: Sharma, Sachin¹ (AUTHOR), Chandra, Kavya² (AUTHOR), Naik, Aliva³ (AUTHOR), Sharma, Anamika³ (AUTHOR), Sharma, Ram¹ (AUTHOR), Thakur, Amandeep¹ (AUTHOR), Grewal, Ajmer Singh⁴ (AUTHOR), Dhingra, Ashwani K.⁴ (AUTHOR), Banerjee, Arnab² (AUTHOR), Liou, Jing Ping^1,5 (AUTHOR), Guru, Santosh Kumar³ (AUTHOR) santoshkumar.guru@niperhyd.ac.in, Nepali, Kunal^1,5 (AUTHOR) nepali@tmu.edu.tw

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-22. 22p.

Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity

Autor: Ji, Tangyang, Jian, Xieer, Chen, Lin, Zeng, Wenbin, Huo, Xiansen, Li, Mingxia, Chen, Peng, Zhang, Yuqi, You, Wenwei, Zhao, Peiliang

Publikováno v: In European Journal of Medicinal Chemistry 5 August 2023 256

S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer.

Autor: Hou, Zhenyan¹ (AUTHOR) houzhenyan@imm.ac.cn, Lin, Songwen^1,2 (AUTHOR) linsongwen@imm.ac.cn, Du, Tingting¹ (AUTHOR) ninadu@imm.ac.cn, Wang, Mingjin¹ (AUTHOR) wangmingjin@imm.ac.cn, Wang, Weida¹ (AUTHOR) wangweida@imm.ac.cn, You, Shen¹ (AUTHOR) youshen@imm.ac.cn, Xue, Nina¹ (AUTHOR) angelnina@imm.ac.cn, Liu, Yichen¹ (AUTHOR), Ji, Ming^1,2 (AUTHOR) jiming@imm.ac.cn, Xu, Heng¹ (AUTHOR) jiming@imm.ac.cn, Chen, Xiaoguang^1,3 (AUTHOR) jiming@imm.ac.cn

Publikováno v: Pharmaceuticals (14248247). May2023, Vol. 16 Issue 5, p749. 21p.

VERU-111, an Orally Available Tubulin Inhibitor, Suppresses Ovarian Tumor Growth and Metastasis.

Autor: Waddell S; University of Tennessee Health Science Center, United States., Zhao G; University of Tennessee Health Science Center, United States., Liu Z; University of Tennessee Health Science Center, United States., Chen H; University of Tennessee Health Science Center, United States., Zhang W; University of Tennessee Health Science Center, United States., Wang Y; Vanderbilt University, United States., Miller DD; 1942, United States., Yue J; University of Tennessee Health Science Center, United States wli@uthsc.edu., Li W; Pharmaceutical Sciences, University of Tennessee Health Science Center, United States wli@uthsc.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 Jun 27. Date of Electronic Publication: 2024 Jun 27.