Tryptophan production by catalysis of a putative tryptophan synthase protein.

Autor: Cao L; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China., Zhang J; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China.; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China., Chen J; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China., Li M; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China., Chen H; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China., Wang C; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China., Gong C; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National '111', Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, 430068, PR China. gongcj606@163.com.

Publikováno v: Archives of microbiology [Arch Microbiol] 2024 Sep 02; Vol. 206 (9), pp. 390. Date of Electronic Publication: 2024 Sep 02.

The β-subunit of tryptophan synthase is a latent tyrosine synthase.

Autor: Almhjell PJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Department of Biochemistry, Stanford University, Stanford, CA, USA., Johnston KE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Merck & Co., Inc, South San Francisco, CA, USA., Porter NJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Codexis, Inc., Redwood City, CA, USA., Kennemur JL; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Bhethanabotla VC; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Ducharme J; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.; Quebec Government Office, Los Angeles, CA, USA., Arnold FH; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. frances@cheme.caltech.edu.; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. frances@cheme.caltech.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2024 Aug; Vol. 20 (8), pp. 1086-1093. Date of Electronic Publication: 2024 May 14.

A Molecular Dynamics Simulation Study of the Effects of βGln114 Mutation on the Dynamic Behavior of the Catalytic Site of the Tryptophan Synthase.

Autor: Roy A; Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A5B7, Canada., Karttunen M; Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A5B7, Canada.; Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A3K7, Canada.; The Centre of Advanced Materials and Biomaterials Research, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A5B7, Canada.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2024 Feb 12; Vol. 64 (3), pp. 983-1003. Date of Electronic Publication: 2024 Jan 30.

Improving the Activity of Tryptophan Synthetase via a Nucleic Acid Scaffold.

Autor: Wang Y; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China., Wang X; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China., Niu S; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China., Cheng W; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China., Liu X; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China., Min Y; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China., Qiu Y; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China., Ma L; State Key Laboratory of Biocatalysis and Enzyme, Engineering Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, Biology Faculty of Hubei University, Hubei University, Wuhan 430062, China., Rao B; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China., Zhu L; Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, China.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Oct 26; Vol. 28 (21). Date of Electronic Publication: 2023 Oct 26.

Tryptophan-synthesizing bacteria enhance colonic motility.

Autor: Legan TB; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA., Lavoie B; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA., Norberg E; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA., Ley IC; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA., Tack S; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA., Tompkins TA; Lallemand Bio Ingredients, Montreal, Quebec, Canada., Wargo MJ; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA., Mawe GM; Department of Neurological Sciences, University of Vermont, Burlington, Vermont, USA.

Publikováno v: Neurogastroenterology and motility [Neurogastroenterol Motil] 2023 Oct; Vol. 35 (10), pp. e14629. Date of Electronic Publication: 2023 Jun 25.