Zobrazeno 1 - 10
of 118
pro vyhledávání: '"trispecific antibody"'
Autor:
Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina, Laura Sanz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
T cell-based immunotherapies for solid tumors have not achieved the clinical success observed in hematological malignancies, partially due to the immunosuppressive effect promoted by the tumor microenvironment, where PD-L1 and TGF-β play a pivotal r
Externí odkaz:
https://doaj.org/article/3126feeb469c436b90c0b4d00590133a
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-20 (2023)
Abstract Immune cell engagers are engineered antibodies with at least one arm binding a tumor-associated antigen and at least another one directed against an activating receptor in immune effector cells: CD3 for recruitment of T cells and CD16a for N
Externí odkaz:
https://doaj.org/article/753183316192449f81abf0e45f4814e5
Autor:
Laura Rubio-Pérez, Susana Frago, Marta Compte, Rocío Navarro, Seandean L. Harwood, Rodrigo Lázaro-Gorines, Marina Gómez-Rosel, Oana Hangiu, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Luis Álvarez-Vallina
Publikováno v:
Antibodies, Vol 13, Iss 2, p 34 (2024)
Immune checkpoint blockade has changed the treatment paradigm for advanced solid tumors, but the overall response rates are still limited. The combination of checkpoint blockade with anti-4-1BB antibodies to stimulate tumor-infiltrating T cells has s
Externí odkaz:
https://doaj.org/article/f4146a3dc0ce4049b9e43fa900b61edb
Publikováno v:
Molecules, Vol 29, Iss 5, p 1140 (2024)
Valued for their ability to rapidly kill multiple tumor cells in succession as well as their favorable safety profile, NK cells are of increasing interest in the field of immunotherapy. As their cytotoxic activity is controlled by a complex network o
Externí odkaz:
https://doaj.org/article/68cfee385c1a47cf8094176669399c9c
Autor:
Julia Harwardt, Stefania C. Carrara, Jan P. Bogen, Katrin Schoenfeld, Julius Grzeschik, Björn Hock, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of t
Externí odkaz:
https://doaj.org/article/9fb531027f17410a9441b28858737aba
Publikováno v:
International Journal of Nanomedicine, Vol Volume 16, Pp 4017-4030 (2021)
Wei-Jie Cheng,1,* Shyr-Yi Lin,2,3,* Michael Chen,4 Ling-Chun Chen,5 Hsiu-O Ho,1 Kuo-Hsiang Chuang,4,6 Ming-Thau Sheu1 1School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan; 2Division of Gastroenterology, Department of In
Externí odkaz:
https://doaj.org/article/ed0b5e28db4f447a8d9856630e8aec6f
Autor:
Ying Cheng, Xiaodong Zheng, Xuefu Wang, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian, Haoyu Sun
Publikováno v:
Cancer Biology & Medicine, Vol 17, Iss 4, Pp 1026-1038 (2020)
Objective: Natural killer (NK) cells have gained considerable attention due to their potential in treating “cold tumors,” and are therefore considered as one of the new strategies for curing cancer, by using worldwide development of their new pos
Externí odkaz:
https://doaj.org/article/07c98faaa4094632a8bc8c5b799e9cb8
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer cell engagers gained enormous interest in recent years due to their potent anti-tumor activity and favorable safety profile. Simultaneously, chicken-derived antibodies entered clinical studies paving the way for avian-derived therapeut
Externí odkaz:
https://doaj.org/article/a90d47a64eea4424ba866d67b3ea3e30
Akademický článek
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