Antimalarial peroxides

Autor: DEJAN M. OPSENICA, BOGDAN A. ŠOLAJA

Publikováno v: Journal of the Serbian Chemical Society, Vol 74, Iss 11, Pp 1155-1193 (2009)

The problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5–2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occu

Externí odkaz: https://doaj.org/article/7ff1defbe5334bed8f23931b3fb13075

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Artemisinins and synthetic peroxides as highly efficient antimalarials

Autor: Dejan Milos Opsenica, Bogdan Aleksandar Šolaja

Publikováno v: Macedonian Journal of Chemistry and Chemical Engineering, Vol 31, Iss 2 (2012)

Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P. falciparum, P. ovale, P. vivax, P. malarie and P. knowlesi, from which P. falciparum

Externí odkaz: https://doaj.org/article/3482677ccd734f01bde75af511431521

Synthesis of spiroannulated and 3-arylated 1,2,4-trioxanes from mesitylol and methyl 4-hydroxytiglate by photooxygenation and peroxyacetalization

Autor: Axel G. Griesbeck, Lars-Oliver Höinck, Jörg M. Neudörfl

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 61 (2010)

Cycloalkanones were utilized in the Lewis acid catalyzed peroxyacetalization of ß-hydroperoxy homoallylic alcohols (prepared by the ene reaction of the allylic alcohols mesitylol and methyl 4-hydroxytiglate, respectively, with singlet oxygen) to giv

Externí odkaz: https://doaj.org/article/674ff03fdc914371b1eb02b856f9f1eb

The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism

Autor: Laura Zaccaro, Orazio Taglialatela-Scafati, Giuseppina Chianese, Ernesto Fattorusso, Biancamaria Farina, Caterina Fattorusso, Arianna Quintavalla, Roberto Fattorusso, Marco Persico, Claudio Trombini, Marco Lombardo, Francesca Rondinelli, Ivan de Paola

Publikováno v: Scientific Reports
Scientific reports (Nature Publishing Group) 7 (2017). doi:10.1038/srep45485
info:cnr-pdr/source/autori:Persico M.; Fattorusso R.; Taglialatela-Scafati O.; Chianese G.; De Paola I.; Zaccaro L.; Rondinelli F.; Lombardo M.; Quintavalla A.; Trombini C.; Fattorusso E.; Fattorusso C.; Farina B./titolo:The interaction of heme with plakortin and a synthetic endoperoxide analogue: New insights into the heme-activated antimalarial mechanism/doi:10.1038%2Fsrep45485/rivista:Scientific reports (Nature Publishing Group)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:7

In the present work we performed a combined experimental and computational study on the interaction of the natural antimalarial endoperoxide plakortin and its synthetic analogue 4a with heme. Obtained results indicate that the studied compounds produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7443cb30faf17a2846f0dc121019cf
http://europepmc.org/articles/PMC5382535