Zobrazeno 1 - 10
of 729
pro vyhledávání: '"trial methodology"'
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Providing informed consent for trials requires providing trial participants with comprehensive information about the trial, including information about potential risks and benefits. It is required by the ethical principle of respe
Externí odkaz:
https://doaj.org/article/a8eca9bc899942edb733fc1283c39d66
Autor:
Victoria Shepherd, Katherine Joyce, Amanda Lewis, Samantha Flynn, Madeleine Clout, Brittany Nocivelli, Jeremy Segrott, Shaun Treweek
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background For the potential benefits of trials to reach all that they should, trials must be designed to ensure that those taking part reflect the population who will receive the intervention. However, adults with impaired capacity to conse
Externí odkaz:
https://doaj.org/article/2bf957d94d80460c93300278b3b0b32e
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-8 (2023)
Abstract Background Clinical research nurses are a key part of the clinical trial team but typically get involved later in the trial, usually during recruitment. The purpose of our study was to establish if CRNs who read the trial protocol can predic
Externí odkaz:
https://doaj.org/article/21e910a6814d4d5da690cd20bcec30a0
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-6 (2023)
Abstract Background Many randomized trials that aim to assess new or commonly used medical or surgical interventions have been so small that the validity of conclusions becomes questionable. Methods We illustrate the small trial problem using the pow
Externí odkaz:
https://doaj.org/article/0738d939bb054ed69f4dbba914c1f5d7
Autor:
Molly Byrne, Mike Clarke, Ian J. Saldanha, Fiona Quirke, Jan Kottner, Jamie Kirkham, Paula Williamson, Katie Mellor, Valerie Smith, Karen Matvienko-Sikar, Elaine Toomey
Publikováno v:
HRB Open Research, Vol 5 (2023)
Background Core outcome sets (COS) represent agreed-upon sets of outcomes, which are the minimum that should be measured and reported in all trials in specific health areas. Use of COS can reduce outcome heterogeneity, selective outcome reporting, an
Externí odkaz:
https://doaj.org/article/bd5caf72c7df41278bd0141f1ff1ace6
Autor:
John McCaffrey, Andrew Hunter
Publikováno v:
HRB Open Research, Vol 6 (2023)
Background Despite methodological improvements in clinical trial design and conduct more generally, methodological limitations persist in trials concerning mental health care. A qualitative Study Within A Trial (Qual-SWAT), embedded in the KARMA-Dep-
Externí odkaz:
https://doaj.org/article/61e28cd50bc843b3a8b86469db085ae2
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-8 (2023)
Abstract Background Poor retention in randomised trials can lead to serious consequences to their validity. Studies within trials (SWATs) are used to identify the most effective interventions to increase retention. Many interventions could be applied
Externí odkaz:
https://doaj.org/article/a0031b7ca8334185926dc26087d56fac
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-5 (2023)
Abstract We recently reported that according to patients and healthcare professionals in breast cancer and nephrology trials, teams conducting the trials got their choice of primary outcome wrong (72% of the time) more often than they got it right (2
Externí odkaz:
https://doaj.org/article/ce2c96f18dec4376999b57bd455e852a
Publikováno v:
HRB Open Research, Vol 6 (2023)
Background: Patient and public involvement (PPI) has the potential to improve the relevance of trial outcomes and improve participant recruitment within clinical trials. However, the literature on PPI approaches, outcomes, and attitudes towards PPI i
Externí odkaz:
https://doaj.org/article/25cb260726fd4da7b8d84e846de12cb0
Publikováno v:
Rural and Remote Health, Vol 23 (2023)
Introduction: People living rurally face health inequities fuelled by social exclusion, access to and awareness of health services, and poor transport links. In order to improve the acceptability, accessibility and applicability of health and care in
Externí odkaz:
https://doaj.org/article/7b8a7737ca3148cfb6a69b63f8acefd8