Výsledky vyhledávání - "transplantation [Induced Pluripotent Stem Cells]"

Transplanted human cones incorporate and function in a murine cone degeneration model

Autor: Gasparini, Sylvia J, Tessmer, Karen, Kurth, Thomas, Busskamp, Volker, Zeck, Günther, Karl, Mike Oliver, Ader, Marius, Reh, Miriam, Wieneke, Stephanie, Carido, Madalena, Völkner, Manuela, Borsch, Oliver, Swiersy, Anka, Zuzic, Marta, Goureau, Olivier

Publikováno v: The journal of clinical investigation 132(12), e154619 (2022). doi:10.1172/JCI154619

Once human photoreceptors die, they do not regenerate, thus photoreceptor transplantation has emerged as a potential treatment approach for blinding diseases. Improvements in transplant organization, donor cell maturation and synaptic connectivity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10678::1ae301eeea943b4e2129c2ddc5084ba8

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Organoid technology for retinal repair

Autor: Sílvia Llonch, Madalena Carido, Marius Ader

Publikováno v: Developmental biology 433(2), 132-143 (2018). doi:10.1016/j.ydbio.2017.09.028

A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retiniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9f7be63b504a49083bd94b532cb5d2
https://pubmed.ncbi.nlm.nih.gov/29291970

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Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

Autor: Frank Edenhofer, Dominic Seiferling, Marc Thier, Tamara Quandel, Per Hoffmann, Oliver Brüstle, Raphaela Gorris, Markus M. Nöthen, Thoralf Opitz, Yenal Bernard Lakes, Stefan Herms, Philipp Wörsdörfer

Publikováno v: Cell Stem Cell
Cell Stem Cell; Vol 10
Cell stem cell 10(4), 473-479 (2012). doi:10.1016/j.stem.2012.03.003

SummaryRecent advances have suggested that direct induction of neural stem cells (NSCs) could provide an alternative to derivation from somatic tissues or pluripotent cells. Here we show direct derivation of stably expandable NSCs from mouse fibrobla

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Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli

Autor: Marita Grønning-Hansen, Ekaterina Smozhanik, Galina Skibo, Malin Parmar, Jemal Tatarishvili, Jens Schouenborg, Daniel Tornero, Olle Lindvall, Zaal Kokaia, Oliver Brüstle, Ruimin Ge, O. M. Tsupykov, Somsak Wattananit, Marcus Granmo, Shane Grealish, Cecilia Laterza, Cristina Rodríguez, Jonas Thelin

Publikováno v: Brain 140(3), aww347 (2017). doi:10.1093/brain/aww347

Transplanted neurons derived from stem cells have been proposed to improve function in animal models of human disease by various mechanisms such as neuronal replacement. However, whether the grafted neurons receive functional synaptic inputs from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4bad2ffae5d78ced024c88848f112f
https://doi.org/10.1093/brain/aww347

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Simple derivation of transgene-free iPS cells by a dual recombinase approach

Autor: Nilima Prakash, Ralf Kuehn, Martin Irmler, Wolfgang Wurst, Anna Pertek, Max Endele, Johannes Beckers, Stavroula Skylaki, Florian Meier

Publikováno v: Molecular biotechnology 56(8), 697-713 (2014). doi:10.1007/s12033-014-9748-y

Mammalian cells can be reprogrammed into induced pluripotent stem cells (iPSCs), a valuable tool for in vitro disease modeling and regenerative medicine. These applications demand for iPSCs devoid of reprogramming factor transgenes, but current proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344d85738787445353001d037b6b7d88
https://pubmed.ncbi.nlm.nih.gov/24677035

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Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment

Autor: Vipan K. Parihar, Jan Strnadel, Vahan Martirosian, Charles L. Limoli, Lori-Ann Christie, Munjal M. Acharya, Lara Riparip

Publikováno v: Acharya, MM; Martirosian, V; Christie, LA; Riparip, L; Strnadel, J; Parihar, VK; et al.(2014). Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment. Stem Cells Translational Medicine, 4(1), 74-83. doi: 10.5966/sctm.2014-0063. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7811221x
Stem cells translational medicine, vol 4, iss 1
Acharya, Munjal M; Martirosian, Vahan; Christie, Lori-Ann; Riparip, Lara; Strnadel, Jan; Parihar, Vipan K; et al.(2015). Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.. Stem cells translational medicine, 4(1), 74-83. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/01k2d449
Acharya, Munjal M; Martirosian, Vahan; Christie, Lori-Ann; Riparip, Lara; Strnadel, Jan; Parihar, Vipan K; et al.(2015). Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment.. Stem cells translational medicine, 4(1), 74-83. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/7dm2f69c

Past preclinical studies have demonstrated the capability of using human stem cell transplantation in the irradiated brain to ameliorate radiation-induced cognitive dysfunction. Intrahippocampal transplantation of human embryonic stem cells and human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55e6da311c1addfa538f29910a09220
http://www.escholarship.org/uc/item/7811221x

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