Zobrazeno 1 - 10
of 581
pro vyhledávání: '"transplant tolerance"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDonor hematopoietic stem cell (DHSC) infusions are increasingly being studied in transplant patients for tolerance induction.MethodsTo analyze the fate of infused DHSCs in patients, we developed an in vitro culture system utilizing CD34+D
Externí odkaz:
https://doaj.org/article/a1c309dd235e4f5b8349aee10f681b9e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death globally and liver transplantation (LT) can serve as the best curative treatment option. However, HCC recurrence after LT remains the major obstacle to the long-term
Externí odkaz:
https://doaj.org/article/503bbf4d984a43c080cdd48f538c4610
Autor:
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. Spicer, Nirupama D. Verma, Suzanne J. Hodgkinson, Bruce M. Hall
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg repres
Externí odkaz:
https://doaj.org/article/9ec5c407df9a4a2ba527e4ce261d5650
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The quest to understand how allogeneic transplanted tissue is not rejected and how tolerance is induced led to fundamental concepts in immunology. First, we review the research that led to the Clonal Deletion theory in the late 1950s that has since d
Externí odkaz:
https://doaj.org/article/63316bdc9d1e43d484326c936946be51
Autor:
Guihuan Liu, Yuming Yu, Fu Feng, Ping Zhu, Hua Zhang, Danni Zhang, Xiaoqiang Feng, Zedan Zhang, Yanjun Liu
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background CD8+CD28− T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28− Ts cells in vitro which exert robust allospecific suppressive capacity in vitro. Results CD8+CD28− Ts c
Externí odkaz:
https://doaj.org/article/7700d049b59d47d2934ce92cbdddfdf8
Autor:
Robert Lowsky, Samuel Strober
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The definition of immune tolerance to allogeneic tissue and organ transplants in laboratory animals and humans continues to be the acceptance of the donor graft, rejection of third-party grafts, and specific unresponsiveness of recipient immune cells
Externí odkaz:
https://doaj.org/article/203b709b7cb74ce7832b2693c5c44b46
Akademický článek
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Autor:
Bruce M. Hall, Rachael M. Hall, Giang T. Tran, Catherine M. Robinson, Paul L. Wilcox, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Suzanne J. Hodgkinson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cyto
Externí odkaz:
https://doaj.org/article/886ca1e1c5ef4eb18f1eef7445395015
Autor:
Ryosuke Nakano, Lillian M. Tran, David A. Geller, Camila Macedo, Diana M. Metes, Angus W. Thomson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Liver allograft recipients are more likely to develop transplantation tolerance than those that receive other types of organ graft. Experimental studies suggest that immune cells and other non-parenchymal cells in the unique liver microenvironment pl
Externí odkaz:
https://doaj.org/article/36f61e7d17bc492b8bd1022bb544ab0a
Autor:
Shiva Pathak, Everett H. Meyer
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Pancreatic islet transplantation is a promising method for the treatment of type 1 and type 3 diabetes whereby replacement of islets may be curative. However, long-term treatment with immunosuppressive drugs (ISDs) remains essential for islet graft s
Externí odkaz:
https://doaj.org/article/ddbb74ff065a40cfa5c0115e0052e623