High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility

Autor: Kazutoyo Osoegawa, Lisa E. Creary, Gonzalo Montero-Martín, Kalyan C. Mallempati, Sridevi Gangavarapu, Stacy J. Caillier, Adam Santaniello, Noriko Isobe, Jill A. Hollenbach, Stephen L. Hauser, Jorge R. Oksenberg, Marcelo A. Fernández-Viňa

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and haplotypes. We genotyped 11 HLA genes in 477 non-Hispanic European MS patients and their 954 unaffected parents using a validated next-generation sequencing

Externí odkaz: https://doaj.org/article/6f58a3c695d94969889570db0135d153

Causal inference in genetic trio studies

Autor: Chiara Sabatti, Emmanuel J. Candès, Matteo Sesia, Stephen Bates

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39

Significance The goal of genome-wide association studies is to identify meaningful relationships between genotypes and outcomes of interest. One challenge in the analysis of genetic data is that not all true statistical associations represent relevan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4826d021d4c67fdc2133fbc01679645
https://doi.org/10.1073/pnas.2007743117

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RTN4 AND FBXL17 GENES ARE ASSOCIATED WITH CORONARY HEART DISEASE IN GENOME-WIDE ASSOCIATION ANALYSIS OF LITHUANIAN FAMILIES

Autor: Zita Aušrelė Kučinskienė, D Vitkus, V Dženkevičiūtė, Ingrida Domarkienė, Aidas Pranculis, Audronė Jakaitienė, Vaidutis Kučinskas, Š Germanas

Publikováno v: Balkan Journal of Medical Genetics, Vol 16, Iss 2, Pp 17-22 (2013)
Balkan Journal of Medical Genetics : BJMG

Coronary heart disease (CHD) is a complex and heterogeneous cardiovascular disease. There are many genome-wide association studies (GWAS) performed worldwide to extract the causative genetic factors. Moreover, each population may have some exceptiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442af2451af2ed7e9f2fb8925759b6f4
https://doi.org/10.2478/bjmg-2013-0026

Lack of Association between the Dopamine Transporter Gene 3'VNTR Polymorphism and Attention Deficit Hyperactivity Disorder in Chinese Han Children : Case-control and Family-based Studies

Autor: YAPING, WANG, ZHAOHUI, WANG, KAINAN, YAO, Tanaka, Kiwamu, YUFENG, YANG, Shirakawa, Osamu, Maeda, Kiyoshi

Publikováno v: The Kobe journal of the medical sciences. 53(6):327-333

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cc74a3591669b02bcda0398c5c3a154b
https://hdl.handle.net/20.500.14094/81000132