The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents

Autor: Mohammad Morshed, Sang Min Lim, Jiyoun Lee, TaeHun Kim, Jae Y Lee, Ha E Lee, Ae N Pae, Suengmok Cho, Sung J Cho, Ashwini M. Londhe, Ji W Lim, Hayoung Hwang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 831-846 (2021)

Small molecule modulators of mitochondrial function have been attracted much attention in recent years due to their potential therapeutic applications for neurodegenerative diseases. The mitochondrial translocator protein (TSPO) is a promising target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0fa0fabd7e8d0c5038c2ad9e5c6779

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein

Autor: Claudia Martini, Elda Severi, Francesca Simorini, Concettina La Motta, Federico Da Settimo, Barbara Cosimelli, Sabrina Taliani, S Bendinelli, Barbara Costa, Giovanni Greco, Ettore Novellino, Eleonora Da Pozzo

Publikováno v: European journal of medicinal chemistry. 46(9)

In this study novel ligands of the translocator protein (TSPO), characterized by a five-membered aromatic heterocycle (i.e. oxazole, isoxazole, oxadiazole), a phenyl ring, and an amide side chain of carboxy or acetic type, were designed using a previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb773f59a0d8aa28c38d76cbb14f060
https://pubmed.ncbi.nlm.nih.gov/21824692

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