Zobrazeno 1 - 10
of 114
pro vyhledávání: '"translesion synthesis (TLS)"'
Autor:
Katarzyna H. Masłowska, Vincent Pagès
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
DNA Damage Tolerance (DDT) functions to bypass replication-blocking lesions and is divided into two distinct pathways: error-prone Translesion Synthesis (TLS) and error-free Damage Avoidance (DA). Rad5 is a multifunctional protein that is involved in
Externí odkaz:
https://doaj.org/article/daeb7ad441dc4cb4a947453e5ec1fbb6
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: REV1 is a member of the translesion synthesis DNA polymerase Y family. It is an essential player in a variety of DNA replication activities, and perform major roles in the production of both spontaneous and DNA damage-induced mutations. T
Externí odkaz:
https://doaj.org/article/207fcbbff2fd43d4b2f7af0ec9e69033
Akademický článek
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Autor:
Megan Perry, Gargi Ghosal
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of variety of agents like reactive oxygen species, aldehydes and metabolites, radiation, and chemotherapeutic drugs
Externí odkaz:
https://doaj.org/article/2f68c13c465d4625b8b8518409ab9cb1
Autor:
Ashlynn Ai Li Ler, Michael P. Carty
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double-strand bre
Externí odkaz:
https://doaj.org/article/e90a697ba2ad4e8696d8e0f5a28174c7
Autor:
Julieta H. Sepúlveda-Yáñez, Diego Alvarez Saravia, Bas Pilzecker, Pauline A. van Schouwenburg, Mirjam van den Burg, Hendrik Veelken, Marcelo A. Navarrete, Heinz Jacobs, Marvyn T. Koning
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. SHM typically creates single nucleotide substitutions, but ta
Externí odkaz:
https://doaj.org/article/13cfd464e6b14ec8890b243b11722750
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3924 (2021)
DNA can experience “replication stress”, an important source of genome instability, induced by various external or endogenous impediments that slow down or stall DNA synthesis. While genome instability is largely documented to favor both tumor fo
Externí odkaz:
https://doaj.org/article/b067b2a5ec6a4b8db64e8e7d10ffd653
Autor:
Bas Pilzecker, Heinz Jacobs
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in optimizing antibody dependent immune
Externí odkaz:
https://doaj.org/article/db3710431d4e4289917ed2574d089e6a
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 902 (2020)
The sustainment of replication and transcription of damaged DNA is essential for cell survival under genotoxic stress; however, the damage tolerance of these key cellular functions comes at the expense of fidelity. Thus, translesion DNA synthesis (TL
Externí odkaz:
https://doaj.org/article/218586edc092407d82f0f6f20c41f850