Zobrazeno 1 - 10
of 6 495
pro vyhledávání: '"translational control"'
Autor:
Anna Herrmannová, Jan Jelínek, Klára Pospíšilová, Farkas Kerényi, Tomáš Vomastek, Kathleen Watt, Jan Brábek, Mahabub Pasha Mohammad, Susan Wagner, Ivan Topisirovic, Leoš Shivaya Valášek
Publikováno v:
eLife, Vol 13 (2024)
Protein synthesis plays a major role in homeostasis and when dysregulated leads to various pathologies including cancer. To this end, imbalanced expression of eukaryotic translation initiation factors (eIFs) is not only a consequence but also a drive
Externí odkaz:
https://doaj.org/article/86858da3f3d24ee1bcdd83771bd9fdc5
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102034- (2024)
Objective: Brown adipose tissue (BAT) plays an important role in mammalian thermogenesis through the expression of uncoupling protein 1 (UCP1). Our previous study identified cytoplasmic polyadenylation element binding protein 2 (CPEB2) as a key regul
Externí odkaz:
https://doaj.org/article/962f591a3e5544abaae4ba165ea9d6ce
Akademický článek
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Autor:
Yun Li, Zongyu Yu, Wenlin Jiang, Xinyi Lyu, Ailian Guo, Xiaorui Sun, Yiting Yang, Yunfang Zhang
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1340 (2024)
As the most ancient RNA, transfer RNAs (tRNAs) play a more complex role than their constitutive function as amino acid transporters in the protein synthesis process. The transcription and maturation of tRNA in cells are subject to stringent regulatio
Externí odkaz:
https://doaj.org/article/a024b83832d84db99471beeda2c33ea2
Autor:
Igor Patrick Vasconcelos Vieira, Felipe Seixas Arreguy Pimentel, Cintia Marques Coelho, Janice Lisboa De Marco, Lidia Maria Pepe de Moraes, Fernando Araripe Gonçalves Torres
Publikováno v:
AMB Express, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract The methylotrophic yeast Komagataella phaffii is one of the most important microbial platforms to produce recombinant proteins. Despite its importance in the context of industrial biotechnology, the use of synthetic biology approaches in K.
Externí odkaz:
https://doaj.org/article/edb11a4d8c9e4b818ae01b77a5ea4570
Autor:
Christine Pourciau, Helen Yakhnin, Archanna Pannuri, Mark G. Gorelik, Ying-Jung Lai, Tony Romeo, Paul Babitzke
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTBacterial growth rate varies due to changing physiological signals and is fundamentally dependent on protein synthesis. Consequently, cells alter their transcription and translation machinery to optimize the capacity for protein production un
Externí odkaz:
https://doaj.org/article/bd4f3656263947638ce7efa9b1b716b6
Listeria monocytogenes folate metabolism is required to generate N-formylmethionine during infection
Autor:
Qing Tang, Michelle L. Reniere
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Folic acid and its derivatives are required for the synthesis of purines, pyrimidines, and some amino acids. Antifolate antibiotics that target the folic acid metabolism pathway are commonly used for the treatment of listeriosis caused by th
Externí odkaz:
https://doaj.org/article/1353f6aabc3c47a483d6a86bb44a9b3a
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Azoles are commonly used for the treatment of fungal infections, and the ability of human fungal pathogens to rapidly respond to azole treatment is critical for the development of antifungal resistance. While the roles of genetic mutations,
Externí odkaz:
https://doaj.org/article/e7c1156b17fe4264a7b565343b831013
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/09865cc95f4b421789ac77f657ff609a
Publikováno v:
Cells, Vol 13, Iss 1, p 35 (2023)
Glutamyl-prolyl-tRNA synthetase (EPRS1), an aminoacyl-tRNA synthetase (ARS) ligating glutamic acid and proline to their corresponding tRNAs, plays an essential role in decoding proline codons during translation elongation. The physiological function
Externí odkaz:
https://doaj.org/article/dd8c22ae2376436998a2dc491f0877a3