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Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type–specific and mediated by an N-terminal volume-sensing domain

Autor: David Križaj, Nanna MacAulay, Tam T. T. Phuong, Trine Lisberg Toft-Bertelsen, Oleg Yarishkin, Sarah Redmon

Publikováno v: J Biol Chem
Toft-Bertelsen, T L, Yarishkin, O, Redmon, S, Phuong, T T T, Krizaj, D & MacAulay, N 2019, ' Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain ', Journal of Biological Chemistry, vol. 294, no. 48, pp. 18421-18434 . https://doi.org/10.1074/jbc.RA119.011187

Many retinal diseases are associated with pathological cell swelling, but the underlying etiology remains to be established. A key component of the volume-sensitive machinery, the transient receptor potential vanilloid 4 (TRPV4) ion channel, may repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8d0e43adff4715023172562364b329
https://doi.org/10.1074/jbc.ra119.011187

Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvβ1 subunit

Autor: Conghui Ping, Chang Xie, Yuanyuan Wang, Xiaoyi Mo, Bo Zhong, Jing Yao, Dongdong Li, Qian Huang, Hao Zhang

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (50), pp.17337-17348. ⟨10.1074/jbc.ra120.015605⟩
Journal of Biological Chemistry, 2020, 295 (50), pp.17337-17348. ⟨10.1074/jbc.ra120.015605⟩

International audience; Transient receptor potential vanilloid 1 (TRPV1) channel is a multimodal receptor that is responsible for nociceptive, thermal, and mechanical sensations. However, which biomolecular partners specifically interact with TRPV1 r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d2efa7137eadde825b40ea36344027
https://pubmed.ncbi.nlm.nih.gov/33060203

Depletion of plasma membrane–associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg2+, spermine, and pH

Autor: Gerald M. Alter, Krystyna Blanka Wieczerzak, Tetyana Zhelay, Pavani Beesetty, Masayuki Matsushita, J. Ashot Kozak

Publikováno v: The Journal of Biological Chemistry

Transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ion channel/protein kinase belonging to the TRP melastatin and eEF2 kinase families. Under physiological conditions, most native TRPM7 channels are inhibited by cytoplasmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9442d1ab174f49918eb5ac791552d592
http://europepmc.org/articles/PMC6254349

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

Autor: John D. Chan, Paul McCusker, Sang-Kyu Park, Gihan S. Gunaratne, Peter I. Dosa, Jonathan S. Marchant, Francie Moehring, Cheryl L. Stucky, Evgeny G. Chulkov

Publikováno v: The Journal of Biological Chemistry

The anthelmintic drug praziquantel (PZQ) is used to treat schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. PZQ causes Ca2+ influx and spastic paralysis of adult worms and rapid vacuolization of the worm su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdbc18bd2b49b0c6ad3d70fb939d708
https://pubmed.ncbi.nlm.nih.gov/31653697