Zobrazeno 1 - 10
of 663
pro vyhledávání: '"transforming growth factor β (TGF-β)"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundGastric cancer (GC) ranks as the fifth most prevalent cancer globally, and its pronounced invasiveness and propensity to spread provide significant challenges for therapy. At present, there are no efficacious medications available for the t
Externí odkaz:
https://doaj.org/article/31c5f8e26a1e44149b35f7c4d3d2b791
Publikováno v:
In Experimental Eye Research February 2025 251
Publikováno v:
Journal of Kerman University of Medical Sciences, Vol 31, Iss 1, Pp 40-45 (2024)
Background and Aims Since in patients with type 2 diabetes (T2DM), there is an imbalance of inflammatory cells, the presence of inflammatory cytokines and defects in homeostasis are possible. The present study aimed to evaluate the percentage of Treg
Externí odkaz:
https://doaj.org/article/5aab63f233f443a49178274b78a0b49a
Autor:
Hideki Kumagai, Akira Sasaki, Akira Umemura, Keisuke Kakisaka, Takeshi Iwaya, Satoshi S Nishizuka
Publikováno v:
Endocrine Journal, Vol 71, Iss 2, Pp 139-152 (2023)
Nonalcoholic fatty liver disease (NAFLD) develops as a result of unhealthy lifestyle but improves with laparoscopic sleeve gastrectomy (LSG). The transforming growth factor (TGF)-β signaling pathway reportedly contributes to liver fibrosis, mainly i
Externí odkaz:
https://doaj.org/article/8f82b28f52a649cc8cf9b07259d3e955
Publikováno v:
Cells, Vol 13, Iss 17, p 1493 (2024)
TGF-β plays a pivotal role in the pathogenesis of GO by promoting orbital tissue remodeling and fibrosis. This process involves the stimulation of orbital fibroblasts, leading to myofibroblast differentiation, increased production of inflammatory me
Externí odkaz:
https://doaj.org/article/4cf1778fd8af4a9d931a39a9e7767214
Autor:
Minu Bajpai, Hari Kishan
Publikováno v:
National Board of Examinations Journal of Medical Sciences, Vol 1, Iss 8, Pp 484-496 (2023)
Objective: The aim of the present study is to evaluate the role of urinary transforming growth factor – β1 (uTGF-β1) in congenital unilateral pelvi-ureteric junction obstruction (PUJO) upto the point of developing conventional indications for sur
Externí odkaz:
https://doaj.org/article/42fc3c5d979345e89afd76a322ef350b
Autor:
Li, Bo a, ⁎, 1, Li, Wei b, c, 1, Liao, Yueqi d, Weng, Zhijie b, Chen, Yafei e, Ouchi, Takehito f, Fan, Yi g, Zhao, Zhihe a, Li, Longjiang b, ⁎
Publikováno v:
In Journal of Advanced Research December 2024
Autor:
Shehnaz Bano, Matthew A. Copeland, John W. Stoops, Anne Orr, Siddhi Jain, Shirish Paranjpe, Raja Gopal Reddy Mooli, Sadeesh K. Ramakrishnan, Joseph Locker, Wendy M. Mars, George K. Michalopoulos, Bharat Bhushan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 4, Pp 101380- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disorder, with no approved treatment. Our previous work demonstrated the efficacy of a pan-ErbB inhibitor, Canertinib, in
Externí odkaz:
https://doaj.org/article/f29f693fd932476384c13a2ebe3c29a5
Autor:
Changwei Liu, Li Ni, Xiaoxue Li, Hanyu Rao, Wenxin Feng, Yiwen Zhu, Wei Zhang, Chunxiao Ma, Yue Xu, Liming Gui, Ziyi Wang, Rebiguli Aji, Jin Xu, Wei‐Qiang Gao, Li Li
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background Renal fibrosis is the final development pathway and the most common pathological manifestation of chronic kidney disease. Epigenetic alteration is a significant intrinsic factor contributing to the development of renal fibrosis. S
Externí odkaz:
https://doaj.org/article/48c69ae3f5cb4101a3dcd854056e605c
Publikováno v:
Guoji Yanke Zazhi, Vol 22, Iss 12, Pp 1977-1981 (2022)
Transforming growth factor-β(TGF-β)is a multifunctional biologic factor involved in the regulation of cell proliferation, apoptosis, differentiation, immune function and inflammatory response of the body. TGF-β signaling pathway-mediated myofibrob
Externí odkaz:
https://doaj.org/article/96cee7c361a14961b6002855e049daba