Zobrazeno 1 - 10
of 11
pro vyhledávání: '"transcriptome/drug effects"'
Publikováno v:
Archives of Toxicology. 93:3067-3098
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses major threats to both patient health and drug development in the pharmaceutical industry. A number of human liver cell-based in vitro models combined with toxicoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2bbf8ee49c1491affb3577c1e40f5
https://doi.org/10.1007/s00204-019-02585-5
https://doi.org/10.1007/s00204-019-02585-5
Autor:
Jens M. Kelm, S. Messner, T. M. de Kok, Jian Jiang, M.H.M. van Herwijnen, Danyel Jennen, J.C.S. Kleinjans
Publikováno v:
Toxicology Letters, 312, 34-44. Elsevier Ireland Ltd
Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues, a co-culture of primary human hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b284f6f67c1475aa6ddc29b7c7a153
https://doi.org/10.1016/j.toxlet.2019.05.004
https://doi.org/10.1016/j.toxlet.2019.05.004
Autor:
Maciej Tomaszewski, Louise M Burrell, Stephen Harrap, Damian Skrypnik, Eddie Cano-Gamez, Sean G. Byars, Adam Greenstein, Maciej Glyda, Anthony M. Heagerty, Michelle C. Maier, Priscilla R. Prestes, Andrzej Antczak, Fadi J. Charchar, Xiao Jiang, Joanna Zywiec, Andrew P. Morris, Matthew Denniff, Bernard Keavney, Gosia Trynka, David Scannali, Xiaoguang Xu, Paweł Bogdański, Adrian S. Woolf, Alicja Nazgiewicz, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, James Eales, Bryan Williams, Tomasz J. Guzik, Nilesh J. Samani, Robert Król, Sushant Saluja, Monika Szulińska
Publikováno v:
Jiang, X, Eales, J M, Scannali, D, Nazgiewicz, A, Prestes, P, Maier, M, Denniff, M, Xu, X, Saluja, S, Cano-Gamez, E, Wystrychowski, W, Szulinska, M, Antczak, A, Byars, S, Skrypnik, D, Glyda, M, Król, R, Zywiec, J, Zukowska-Szczechowska, E, Burrell, L M, Woolf, A S, Greenstein, A, Bogdanski, P, Keavney, B, Morris, A P, Heagerty, A, Williams, B, Harrap, S B, Trynka, G, Samani, N J, Guzik, T J, Charchar, F J & Tomaszewski, M 2020, ' Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney ', European Heart Journal, vol. 41, no. 48, pp. 4580-4588 . https://doi.org/10.1093/eurheartj/ehaa794
Eur Heart J
European Heart Journal
Eur Heart J
European Heart Journal
Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 (COVID-19). However, the effect of renin-angiotensin system (RAS)-inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481d135a224eaa582028c5e25333c9d8
http://www.scopus.com/inward/record.url?scp=85099324025&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85099324025&partnerID=8YFLogxK
Autor:
Cristina I. Caescu, Francesco Ramirez, Roshan Borkar, Jay D. Humphrey, Guillaume Jondeau, Bart Spronck, Pauline Arnaud, Evren U. Azeloglu, Jens Hansen, Alan D. Weinberg, Maria Bintanel-Morcillo, Sae-Il Murtada, Ravi Iyengar, Catherine Boileau, James M. Gallo, Rhodora Cristina Calizo, Josephine Galatioto
Publikováno v:
JCI INSIGHT, 4(11):027652. American Society for Clinical Investigation
Marfan syndrome (MFS) is associated with mutations in fibrillin-1 that predispose afflicted individuals to progressive thoracic aortic aneurysm (TAA) leading to dissection and rupture of the vessel wall. Here we combined computational and experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc854adf7edabc91dc15990a05ecbe9
https://cris.maastrichtuniversity.nl/en/publications/5bb48844-d5dc-4bc6-9fe9-a20fe1efecac
https://cris.maastrichtuniversity.nl/en/publications/5bb48844-d5dc-4bc6-9fe9-a20fe1efecac
Autor:
Arwen W. Gao, Aldo Jongejan, Rashmi Kamble, Georges E. Janssens, Michel van Weeghel, Marte Molenaars, Alyson W. MacInnes, Riekelt H. Houtkooper, Yasmine J. Liu, Rebecca L. McIntyre
Publikováno v:
PLoS Genetics, 15(3):e1007633. Public Library of Science
PLoS Genetics, Vol 15, Iss 3, p e1007633 (2019)
PLOS Genetics
PLoS Genetics
PLoS genetics, 15(3):e1007633. Public Library of Science
PLoS Genetics, Vol 15, Iss 3, p e1007633 (2019)
PLOS Genetics
PLoS Genetics
PLoS genetics, 15(3):e1007633. Public Library of Science
The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features associated with aging animals. We previously reported that the levels of most amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f6a39d4c4bcc4a6bf1046e5727079a
https://research.vumc.nl/en/publications/a572bf02-c4f3-490f-868d-c4a568db7f08
https://research.vumc.nl/en/publications/a572bf02-c4f3-490f-868d-c4a568db7f08
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Huff, M, da Silveira, W, Carnevali, O, Renaud, L & Hardiman, G 2018, ' Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP) ', Nature Scientific Reports, vol. 8, no. 1, 2118, pp. 1-17 . https://doi.org/10.1038/s41598-018-20266-8, https://doi.org/10.1038/s41598-018-20266-8
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Huff, M, da Silveira, W, Carnevali, O, Renaud, L & Hardiman, G 2018, ' Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP) ', Nature Scientific Reports, vol. 8, no. 1, 2118, pp. 1-17 . https://doi.org/10.1038/s41598-018-20266-8, https://doi.org/10.1038/s41598-018-20266-8
The organic compound diethylhexyl phthalate (DEHP) represents a high production volume chemical found in cosmetics, personal care products, laundry detergents, and household items. DEHP, along with other phthalates causes endocrine disruption in male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7e6c0eb2917260e8f1ef14305f350b
http://europepmc.org/articles/PMC5794889
http://europepmc.org/articles/PMC5794889
Publikováno v:
Romão, V C, Vital, E M, Fonseca, J E & Buch, M H 2017, ' Right drug, right patient, right time : aspiration or future promise for biologics in rheumatoid arthritis? ', Arthritis Research & Therapy, vol. 19, no. 1, pp. 239 . https://doi.org/10.1186/s13075-017-1445-3
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-13 (2017)
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-13 (2017)
© The Author(s). 2017. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ee618ae7e2a2039a16ec53efab40eb
https://doi.org/10.1186/s13075-017-1445-3
https://doi.org/10.1186/s13075-017-1445-3
Autor:
Tim S. Nawrot, Martien Peusens, Charlotte Vanpoucke, Jos C. S. Kleinjans, Wouter Lefebvre, Ellen Winckelmans, Hans Reynders, Theo M. de Kok, Michelle Plusquin, Greet Schoeters, Maria Tsamou, Karen Vrijens, Willy Baeyens, Elly Den Hond, Nicolas Van Larebeke
Publikováno v:
Environmental Health, 16:87. BioMed Central Ltd
Environmental Health
Winckelmans, E, Nawrot, T S, Tsamou, M, Den Hond, E, Baeyens, W, Kleinjans, J, Lefebvre, W, Van Larebeke, N, Peusens, M, Plusquin, M, Reynders, H, Schoeters, G, Vanpoucke, C, De Kok, T M & Vrijens, K 2017, ' Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure ', Environmental Health: A Global Access Science Source, vol. 16, 87 . https://doi.org/10.1186/s12940-017-0292-7
Environmental health: a global access science source
Environmental Health, Vol 16, Iss 1, Pp 1-15 (2017)
Environmental Health
Winckelmans, E, Nawrot, T S, Tsamou, M, Den Hond, E, Baeyens, W, Kleinjans, J, Lefebvre, W, Van Larebeke, N, Peusens, M, Plusquin, M, Reynders, H, Schoeters, G, Vanpoucke, C, De Kok, T M & Vrijens, K 2017, ' Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure ', Environmental Health: A Global Access Science Source, vol. 16, 87 . https://doi.org/10.1186/s12940-017-0292-7
Environmental health: a global access science source
Environmental Health, Vol 16, Iss 1, Pp 1-15 (2017)
Background: Due to their lack of repair capacity mitochondria are critical targets for environmental toxicants. We studied genes and pathways reflecting mitochondrial responses to short-and medium-term PM10 exposure. Methods: Whole genome gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f010bdce24cad6c2a54858d9c4b9c1c9
https://cris.maastrichtuniversity.nl/en/publications/69313513-a67a-4719-89ae-aeb4d9d243e4
https://cris.maastrichtuniversity.nl/en/publications/69313513-a67a-4719-89ae-aeb4d9d243e4
Publikováno v:
Insect biochemistry and molecular biology, vol. 85, pp. 21-31
Phytophagous insects have to deal with toxic defense compounds from their host plants. Although it is known that insects have evolved genes and mechanisms to detoxify plant allochemicals, how specialist and generalist precisely respond to specific se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb5afe1d371b1a2ff7386688d7745d2
https://pubmed.ncbi.nlm.nih.gov/28455184
https://pubmed.ncbi.nlm.nih.gov/28455184
Autor:
Wim H. A. Dokter, Bruno Guigas, Jacob de Vlieg, Wynand Alkema, Margot M. Linssen, Wilco W. M. Fleuren, D. Margriet Ouwens, Erik J M Toonen, Gerard C.M. van der Zon
Publikováno v:
Archives of Physiology and Biochemistry, 119, 52-64
Archives of Physiology and Biochemistry, 119(2), 52-64
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry, 119(2), 52-64. Swets & Zeitlinger
Archives of Physiology and Biochemistry, 119, 2, pp. 52-64
Archives of Physiology and Biochemistry, 119(2), 52-64
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry, 119(2), 52-64. Swets & Zeitlinger
Archives of Physiology and Biochemistry, 119, 2, pp. 52-64
Contains fulltext : 117166.pdf (Publisher’s version ) (Open Access) Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9011fbcb761062c5e728fe89359da48a
http://hdl.handle.net/2066/117166
http://hdl.handle.net/2066/117166