Zobrazeno 1 - 10
of 1 354
pro vyhledávání: '"transcriptional regulators"'
Autor:
Junyue Li, Kai Wang, Sainan Luo, Yuqing Tian, Yue Li, Songnian Hu, Huarong Tan, Jihui Zhang, Jine Li
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Microbial genome sequencing and analysis revealed the presence of abundant silent secondary metabolites biosynthetic gene clusters (BGCs) in streptomycetes. Activating these BGCs has great significance for discovering new compound
Externí odkaz:
https://doaj.org/article/93c00ee620d946448a6e7920d68a8d3a
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background The macrolide antibiotic avermectin, a natural product derived from Streptomyces avermitilis, finds extensive applications in agriculture, animal husbandry and medicine. The mtrA (sav_5063) gene functions as a transcriptional regu
Externí odkaz:
https://doaj.org/article/88d34743770741579e06e71eb6da299d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Metal ions are essential trace elements for all living organisms and play critical catalytic, structural, and allosteric roles in many enzymes and transcription factors. Mycobacterium tuberculosis (MTB), as an intracellular pathogen, is usually found
Externí odkaz:
https://doaj.org/article/f9e1f75791cc4d3288f27af7448f48d4
Publikováno v:
Genes and Diseases, Vol 10, Iss 5, Pp 2049-2063 (2023)
In Pseudomonas aeruginosa (P. aeruginosa), transcription factors (TFs) are important mediators in the genetic regulation of adaptability and pathogenicity to respond to multiple environmental stresses and host defences. The P. aeruginosa genome harbo
Externí odkaz:
https://doaj.org/article/192369bdb00c43c89eecc8d38dbfc9e3
Publikováno v:
Journal of Magnetic Resonance Open, Vol 16, Iss , Pp 100114- (2023)
Staphylococcus aureus CzrA is a paradigmatic member of the ArsR family of transcriptional metalloregulators, which are critical for the bacterial response to stress. Zinc binding to CzrA, which induces DNA derepression, is entropically driven, as sho
Externí odkaz:
https://doaj.org/article/a52c001bcdc74b6c979ea793c1b6e43e
Autor:
Thanh Quang Nguyen, Bo Eun Heo, Yujin Park, Seunghyeon Jeon, Arunima Choudhary, Cheol Moon, Jichan Jang
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT There is an unmet medical need for effective treatments against Mycobacterium abscessus infections. Although advanced molecular genetic tools to validate drug targets and resistance of M. abscessus exist, the practical design and constructio
Externí odkaz:
https://doaj.org/article/f71c57ac71f948f7993a270537292da2
Autor:
William L. Johnson, Sushim Kumar Gupta, Suman Maharjan, Randy M. Morgenstein, Ainsley C. Nicholson, John R. McQuiston, John E. Gustafson
Publikováno v:
Antibiotics, Vol 13, Iss 1, p 61 (2024)
The Gram-negative Elizabethkingia express multiple antibiotic resistance and cause severe opportunistic infections. Vancomycin is commonly used to treat Gram-positive infections and has also been used to treat Elizabethkingia infections, even though
Externí odkaz:
https://doaj.org/article/689199fcdadb4f75ab84d1bff3d7d92a
Akademický článek
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Autor:
Sadia Sultana, Jan-Ulrik Dahl
Publikováno v:
Biology Open, Vol 12, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/23dc7047f36d4021ac80c920e98c4296
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundIntervertebral disc (IVD) shows aging and degenerative changes earlier than any other body connective tissue. Its repair and regeneration provide a considerable challenge in regenerative medicine due to its high degree of infrastructure and
Externí odkaz:
https://doaj.org/article/365be71ba98244caafcc90ed5b4bc490