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Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

Autor: James Lee, Leman Simpson, Yi Li, Samuel Becker, Fan Zou, Xin Zhang, Lu Bai

Publikováno v: eLife, Vol 13 (2024)

Some transcription factors (TFs) can form liquid–liquid phase separated (LLPS) condensates. However, the functions of these TF condensates in 3-Dimentional (3D) genome organization and gene regulation remain elusive. In response to methionine (met)

Externí odkaz: https://doaj.org/article/b8a40d66bfcf464ab36ce17f37280377

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Transcription Factor Condensates Mediate Clustering of MET Regulon and Enhancement in Gene Expression.

Autor: Lee J; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.; Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA, 16802, USA., Simpson L; Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA., Li Y; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.; Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA, 16802, USA., Becker S; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Zou F; Department of Physics, The Pennsylvania State University, University Park, PA, 16802, USA., Zhang X; Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA., Bai L; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA.; Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Physics, The Pennsylvania State University, University Park, PA, 16802, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 12. Date of Electronic Publication: 2024 Jul 12.

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