Zobrazeno 1 - 10
of 726
pro vyhledávání: '"transcription factor EB"'
Autor:
Asmita Sapkota, Eun-Jin Park, Young Jae Kim, Jong Beom Heo, Thanh Quang Nguyen, Bo Eun Heo, Jin Kyung Kim, Sang-Hee Lee, Soo In Kim, Yoon-Jung Choi, Taylor Roh, Sang Min Jeon, Marnpyung Jang, Hae Joon Heo, Jake Whang, Seungwha Paik, Jae-Min Yuk, Jin-Man Kim, Gyu Yong Song, Jichan Jang, Eun-Kyeong Jo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117313- (2024)
Mycobacteroides abscessus (Mabc) is a rapidly growing nontuberculous mycobacterium that poses a considerable challenge as a multidrug-resistant pathogen causing chronic human infection. Effective therapeutics that enhance protective immune responses
Externí odkaz:
https://doaj.org/article/559b67aedb1c4718a2c7b8ccb6033731
Autor:
Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yang
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-24 (2024)
Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of diffe
Externí odkaz:
https://doaj.org/article/df673dbc95c04f9d9dc2c62b7ff993ba
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
MiT family translocation renal cell carcinomas (tRCCs) primarily include Xp11.2/transcription factor E3 (TFE3) gene fusion-associated renal cell carcinoma (Xp11.2 tRCC) and t(6;11)/TFEB gene fusion-associated RCC. Clinical cases of these carcinomas a
Externí odkaz:
https://doaj.org/article/404c7c4686fe4ba180b4addc65905ede
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 26, Iss 11, Pp 1342-1349 (2023)
Objective(s): Tumor metastasis is the leading cause of death in breast cancer (BC) patients and is a complicated process. Mitochondrial calcium uniporter (MCU), a selective channel responsible for mitochondrial Ca2+ uptake, has been reported to be as
Externí odkaz:
https://doaj.org/article/7baeae1085724c5e990d161782639c3c
Autor:
Samuel Abokyi, Dennis Yan-yin Tse
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 366-377 (2025)
Retinal aging has been recognized as a significant risk factor for various retinal disorders, including diabetic retinopathy, age-related macular degeneration, and glaucoma, following a growing understanding of the molecular underpinnings of their de
Externí odkaz:
https://doaj.org/article/2ca9cbdeaa4e4f8a9702d715ad7036fc
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Impaired autophagy in plaque-associated microglia (PAM) has been reported to accelerate amyloid plaque deposition and cognitive impairment in AD pathogenes
Externí odkaz:
https://doaj.org/article/37028961934549d3ab71731ecf0c6fc5
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 2, Pp 162-170 (2023)
Objective·To investigate the changes of transcription factor EB (TFEB), the activity of the upstream proteins and autophagy in the hippocampus of mice with type 2 diabetic encephalopathy.Methods·Twenty healthy 8-week-old male C57BL/6J mice were ran
Externí odkaz:
https://doaj.org/article/523f575f4d03404183a34a5560acbedf
Autor:
Wenjia Lin, Zhao Li, Guangfeng Liang, Runjin Zhou, Xiaoyan Zheng, Rongrong Tao, Qingwei Huo, Chengfu Su, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background The impairment in the autophagy-lysosomal pathway (ALP) and the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration and neuroinflammation in Alzheimer
Externí odkaz:
https://doaj.org/article/fafb282201584b0caa73453098e4686f
Autor:
Cong Liu, Dawang Zhou, Qiang Zhang, Hongyan Wei, Yuanzheng Lu, Bo Li, Haohong Zhan, Jingge Cheng, Chuyue Wang, Yilin Yang, Shuhao Li, Chunlin Hu, Xiaoxing Liao
Publikováno v:
PeerJ, Vol 11, p e15841 (2023)
Background Adverse left ventricular remodeling after myocardial infarction (MI) compromises cardiac function and increases heart failure risk. Until now, comprehension of the role transcription factor EB (TFEB) plays after MI is limited. Objectives T
Externí odkaz:
https://doaj.org/article/515fdc95ad3649589424c347c39f33a1
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a leading cause of end-stage renal disease worldwide. Autophagy plays an important role in maintaining cellular homeostasis in renal physiology. In DKD, the accumulat
Externí odkaz:
https://doaj.org/article/c8862d8e5f1b48b199419311812c1d0b