Zobrazeno 1 - 10
of 14
pro vyhledávání: '"transcription/export complex"'
Autor:
Belén Pacheco-Fiallos, Clemens Plaschka, Laura Fin, Ulrich Hohmann, Thomas Pühringer, Ulla Schellhaas, Julius Brennecke
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a402f54d06a001bcf6b0c485e6625598
https://doi.org/10.7554/elife.61503
https://doi.org/10.7554/elife.61503
Arabidopsis centrin 2, also known as calmodulin-like protein 19 (CML19), is a member of the EF-hand superfamily of calcium (Ca2+)-binding proteins. In addition to the notion that CML19 interacts with the nucleotide excision repair protein RAD4, CML19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2df9f285db7c073f1436edbd11ab99c
http://hdl.handle.net/11562/1011478
http://hdl.handle.net/11562/1011478
Autor:
Mohamad Maghnie, Andrea Accogli, Mariasavina Severino, Annalisa Calcagno, Maria Margherita Mancardi, Raffaele Castello, Annalaura Torella, Vincenzo Nigro, Anna Allegri, Marcello Scala, Francesco Musacchia, Valeria Capra
THO/TREX (transcription/export) is a conserved eukaryotic complex that plays a crucial role in gene expression and prevents DNA damage during mitosis and meiosis. In mammals, TREX is essential during embryogenesis, determining stem cell fate specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c97689010d2753ca8aeafe4c174cb2
http://hdl.handle.net/11591/403208
http://hdl.handle.net/11591/403208
Autor:
Scott E. Martin, Mahlet B. Abera, Yu-Chi Chen, Eugen Buehler, Rebecca M. Gibbs, Kenneth H. Fischbeck, Lu Chen, Barrington G. Burnett, Eveline S. Arnold, Nikki M. McCormack
Publikováno v:
Cell reports
SUMMARY Spinal muscular atrophy (SMA) is a debilitating neurological disorder marked by degeneration of spinal motor neurons and muscle atrophy. SMA results from mutations in survival motor neuron 1 (SMN1), leading to deficiency of survival motor neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05019e6b4b3abf4424bde106b257e87a
https://doi.org/10.1016/j.celrep.2021.109125
https://doi.org/10.1016/j.celrep.2021.109125
Autor:
Jean-Baptiste Rivière, Wendy Alcaraz, Sha Tang, Zohreh Fattahi, Maryam Beheshtian, A. Kariminedjad, Laurence Faivre, A.M. Innes, Hossein Najmabadi, Robert Roger Lebel, Katherine L. Helbig, Julien Thevenon, Seyed Hassan Tonekaboni, Chandree L. Beaulieu, Alice Masurel-Paulet, J.S. Amos, Lijia Huang, Kym M. Boycott
Publikováno v:
Clinical Genetics. 91:92-99
THOC6 is a part of the THO complex, which is involved in coordinating mRNA processing with export. The THO complex interacts with additional components to form the larger TREX complex (transcription export complex). Previously, a homozygous missense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c958b8821dc9b278e5a5883c541ed331
https://doi.org/10.1111/cge.12793
https://doi.org/10.1111/cge.12793
Publikováno v:
Nature structural & molecular biology
The conserved TREX-2 transcription-export complex integrates transcription and processing of many actively transcribed nascent mRNAs with the recruitment of export factors at nuclear pores and also contributes to transcriptional memory and genomic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663534d2b110e4bb7effc6cc9e53589f
https://doi.org/10.1038/nsmb.2235
https://doi.org/10.1038/nsmb.2235
Akademický článek
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Autor:
Terri Goss Kinzy, Michael Hampsey
Publikováno v:
Genes & Development. 21:1288-1291
Transcription and translation are coordinated events in all organisms. In prokaryotes, the process that couples these two events is clear: The ribosome begins translation of the nascent mRNA while the DNA template is still being transcribed. Indeed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ac48d3c9117f01728f781460557829f
https://doi.org/10.1101/gad.1564807
https://doi.org/10.1101/gad.1564807
Publikováno v:
Biochemical Journal
The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85f784ec3298f3bf10931336bc5f877e
https://pubmed.ncbi.nlm.nih.gov/24354960
https://pubmed.ncbi.nlm.nih.gov/24354960