Zobrazeno 1 - 10
of 1 251
pro vyhledávání: '"trans-sialidase"'
Autor:
Víctor Torres, Víctor Contreras, Bessy Gutiérrez, Juan San Francisco, Alejandro Catalán, José Luis Vega, Kyung-Mee Moon, Leonard J. Foster, Rafael F. de Almeida, Alexis M. Kalergis, Jorge González
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionOral transmission of T. cruzi is probably the most frequent transmission mechanism in wild animals. This observation led to the hypothesis that consuming raw or undercooked meat from animals infected with T. cruzi may be responsible for t
Externí odkaz:
https://doaj.org/article/f4f5aa49bde24e818511dc3d39a65ba6
Akademický článek
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Autor:
Suleiman Aminu, Gloria Dada Chechet, Samia S. Alkhalil, Mansour Sobeh, Rachid Daoud, Mthokozisi B. Simelane, Elewechi Onyike, Mohammed Auwal Ibrahim
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
BackgroundAfrican animal trypanosomiasis hinders sustainable livestock productivity in sub-Saharan Africa. About 17 million infected cattle are treated with trypanocides annually but most of the drugs are associated with drawbacks, necessitating the
Externí odkaz:
https://doaj.org/article/f0fdc1d5f921480c95eb949f2573edfa
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 208-216 (2022)
Sialic acid is the natural substrate for sialidases and its chemical modification has been a useful approach to generate potent and selective inhibitors. Aiming at advancing the discovery of selective Trypanosoma cruzi trans-sialidase (TcTS) inhibito
Externí odkaz:
https://doaj.org/article/ac9f09de44db475897ef1ba9fc3bbf78
Autor:
Gabriela de A. Burle-Caldas, Nailma S. A. dos Santos, Júlia T. de Castro, Fernanda L. B. Mugge, Viviane Grazielle-Silva, Antônio Edson R. Oliveira, Milton C. A. Pereira, João Luís Reis-Cunha, Anderson Coqueiro dos Santos, Dawidson Assis Gomes, Daniella C. Bartholomeu, Nilmar S. Moretti, Sergio Schenkman, Ricardo T. Gazzinelli, Santuza M. R. Teixeira
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Trans-sialidases (TS) are unusual enzymes present on the surface of Trypanosoma cruzi, the causative agent of Chagas disease. Encoded by the largest gene family in the T. cruzi genome, only few members of the TS family have catalytic activit
Externí odkaz:
https://doaj.org/article/726ccde2ca8642a08b521362024bc308
Autor:
Kelli Monteiro da Costa, Leonardo Marques da Fonseca, Jhenifer Santos dos Reis, Marcos André Rodrigues da Costa Santos, José Osvaldo Previato, Lucia Mendonça-Previato, Leonardo Freire-de-Lima
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Chagas’ disease is caused by the protozoan Trypanosoma cruzi, described in the early 20th century by the Brazilian physician Dr. Carlos Chagas. There was a great amount of research devoted to diagnosis, treatment and prevention of the disease. One
Externí odkaz:
https://doaj.org/article/5683df65cc26441491569c6cf1b3d36c
Akademický článek
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Autor:
Christian Macagnan Probst, Myllena de Fátima Alheiros Dias Melo, Daniela Parada Pavoni, Max Jean de Ornelas Toledo, Tainah Silva Galdino, Adeilton Alves Brandão, Constança Britto, Marco Aurelio Krieger
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 116 (2021)
BACKGROUND Trypanosoma cruzi is an important human pathogen in Latin America with nearly seven million people infected. It has a large degree of genetic diversity, classified into six discrete typing units (DTUs), which probably influences its physio
Externí odkaz:
https://doaj.org/article/f584c3f2b3d94fc18768f23b7548b38e
Autor:
Juan Cruz Gamba, Carolina Roldán, Estefanía Prochetto, Giuliana Lupi, Iván Bontempi, Carolina Verónica Poncini, Mónica Vermeulen, Ana Rosa Pérez, Iván Marcipar, Gabriel Cabrera
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Trypanosoma cruzi (T. cruzi) is a hemoflagellate protozoan parasite that causes Chagas disease, a neglected tropical disease that affects more than 6 million people around the world, mostly in Latin America. Despite intensive research, there is no va
Externí odkaz:
https://doaj.org/article/94109cd8b0d14de4991487b56982fe5f
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Sialic acid (Sia), the acylated derivative of the nine-carbon sugar neuraminic acid, is a terminal component of the oligosaccharide chains of many glycoproteins and glycolipids. In light of its important biological and pathological functions
Externí odkaz:
https://doaj.org/article/6a056ad4fad54a1dbfa0238e7fff7fe9