Zobrazeno 1 - 10
of 1 010
pro vyhledávání: '"tp53 gene"'
Publikováno v:
Journal of Mid-Life Health, Vol 15, Iss 3, Pp 142-152 (2024)
Endometrial cancer primarily undergoes surgical intervention, with adjuvant treatments such as external beam pelvic radiotherapy, vaginal brachytherapy, chemotherapy, and combined therapy investigated in randomized trials. Treatment decisions hinge o
Externí odkaz:
https://doaj.org/article/1af58b39dc374085ad5b1a9e6712af01
Autor:
Maryam Ijaz, Chien-Chin Chen, Rana Khalid Iqbal, Hafiza Aneela Farooq, Rubaida Mehmood, Muhammad Asif, Atif Akbar, Adil Khan, Waseem Ijaz, Mourad Ben Said, Gezahign Fentahun Wondmie, Samir Ibenmoussa, Mohammad K. Okla, Furhan Iqbal
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Colorectal cancer (CRC) is among the most prevalent cancers with a high mortality rate. Both genetic and environmental factors contribute to CRC development. This study aimed to assess the association of single nucleotide polymorphisms (SNPs
Externí odkaz:
https://doaj.org/article/3b939ed9e0744c169045b9a44d83c636
Autor:
Fang Hua, Yue Hu, Guang-Cui He, Si-Han Lai, Ying He, Shan Zhang, Yan Deng, Ying Han, Xiao-Dong Liu, Kun Yang, Hui-Xiu Zhong, Jian Xiao, Zhong-Zheng Zheng, Hai Yi
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Backgroud Li-Fraumeni syndrome is a hereditary tumor syndrome characterized by an elevated risk of malignancy, particularly acute lymphoblastic leukemia (ALL), which can be caused by the heterozygous germline mutation. TP53 gene germline mutation is
Externí odkaz:
https://doaj.org/article/7f0c790b34604c94922cf260475a01c0
Autor:
Thanh Thien Le, Tung Sy Ha, Linh Mai To, Quang Minh Dang, Hoa Thi Phuong Bui, Thanh Duc Tran, Phuong Thi Vu, Hoan Bao Giang, Dung Trung Tran, Xuan-Hung Nguyen
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Li–Fraumeni syndrome (LFS) is a hereditary disorder characterized by an increased risk of developing multiple early-onset cancers, primarily due to germline TP53 mutations. Women and men with this mutation face lifetime cancer risks of 90% and 70%,
Externí odkaz:
https://doaj.org/article/6f747ee09095409ea33b7d8d70f531b6
Publikováno v:
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 32, Iss 1, Pp 7416-7427 (2024)
Introduction: The TP53 gene on the short arm of chromosome 17p, which is known as a tumor suppressor gene, encodes the transcription factor p53, and this factor controls cell cycle progression. This study was done to assess the association of TP53 (r
Externí odkaz:
https://doaj.org/article/d908d435b5664ab98c7f078dbe8488c0
Autor:
E. N. Voropaeva, T. I. Pospelova, M. I. Churkina, A. A. Gurazheva, O. V. Berezina, V. N. Maksimov
Publikováno v:
Успехи молекулярной онкологии, Vol 10, Iss 3, Pp 72-81 (2023)
Introduction. A more in-depth description of molecular events that disrupt the functioning of the p53 signaling pathway is important for understanding the mechanisms of formation and progression of diffuse B-large cell lymphoma (DCCL), as well as its
Externí odkaz:
https://doaj.org/article/2c5a0aec5d9a440d8da969f1b8d4b8a5
Autor:
Igor Araujo Vieira, Guilherme Danielski Viola, Eduarda Heidrich Pezzi, Thayne Woycinck Kowalski, Bruna Vieira Fernandes, Tiago Finger Andreis, Natascha Bom, Giulianna Sonnenstrahl, Yasminne Marinho de Araújo Rocha, Bruno da Silveira Corrêa, Luiza Mezzomo Donatti, Gabriela dos Santos Sant’Anna, Helena von Eye Corleta, Ilma Simoni Brum, Clévia Rosset, Fernanda Sales Luiz Vianna, Gabriel S. Macedo, Edenir Inez Palmero, Patricia Ashton-Prolla
Publikováno v:
Genetics and Molecular Biology, Vol 46, Iss 3 suppl 1 (2024)
Abstract The TP53 3’UTR variant rs78378222 A>C has been detected in different tumor types as a somatic alteration that reduces p53 expression through modification of polyadenylation and miRNA regulation. Its prevalence is not yet known in all tumor
Externí odkaz:
https://doaj.org/article/1842083036564d94b5d4456d0ea54ce3
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10267-10279 (2023)
Abstract Background TP53 mutations have a prognostic significance in relapsed and refractory diffuse large B‐cell lymphoma (rrDLBCL) patients, and their treatment still faces a great challenge. This study aimed to evaluate the prognosis of patients
Externí odkaz:
https://doaj.org/article/a37ef9d39b344ceb8975c4ce4166bbdb
Autor:
Syed Muhammad Ali Haider, Najeeba Harim, Noor ul ain, Warda Altaf, Tayyba Mumtaz, Saad Farukh, Syeda Aiman Hussain, Hassan Mumtaz
Publikováno v:
Journal of Aziz Fatimah Medical and Dental College, Vol 5, Iss 2 (2023)
Objective: To examine the clinical spectrum of breast cancer, its symptoms, presentation, histologic types and different types of its genetic aberrations in the women of reproductive age. Methodology: This Retrospective study was conducted at the Hea
Externí odkaz:
https://doaj.org/article/9f8ffca0094a46909d855a628e8be468
Autor:
Asma Ounalli, Imen Moumni, Amal Mechaal, Aya Chakroun, Mbarka Barmat, Rim El Elj Rhim, Samia Menif, Ines Safra
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGenetic variations in TP53 gene are known to be important in chronic lymphocytic leukemia (CLL) and may cause its inactivation which is associated with an aggressive form of the disease. Single nucleotide polymorphism (rs1042522:G>C) in TP5
Externí odkaz:
https://doaj.org/article/861ae5c3c4f14461a3a0488c10b6ac63