Zobrazeno 1 - 10
of 79
pro vyhledávání: '"toxin inhibitors"'
Autor:
Laura-Oana Albulescu, Adam Westhorpe, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors
Externí odkaz:
https://doaj.org/article/e44e33036d7043608452939fe49851f5
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023)
Abstract Snakebite envenoming is a significant global health challenge, and for over a century, traditional plasma-derived antivenoms from hyperimmunized animals have been the primary treatment against this infliction. However, these antivenoms have
Externí odkaz:
https://doaj.org/article/44dd0191766d4bb287cb302dcc0846fd
Autor:
Katharina Ernst
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Bacterial AB-type toxins are proteins released by the producing bacteria and are the causative agents for several severe diseases including cholera, whooping cough, diphtheria or enteric diseases. Their unique AB-type structure enables their uptake i
Externí odkaz:
https://doaj.org/article/be990d1615914b8d9d4a5cb56c2291bb
Autor:
Maria Braune-Yan, Jinfang Jia, Mary Wahba, Johannes Schmid, Panagiotis Papatheodorou, Holger Barth, Katharina Ernst
Publikováno v:
Toxins, Vol 15, Iss 6, p 384 (2023)
Clostridioides difficile infections cause severe symptoms ranging from diarrhea to pseudomembranous colitis due to the secretion of AB-toxins, TcdA and TcdB. Both toxins are taken up into cells through receptor-mediated endocytosis, autoproteolytic p
Externí odkaz:
https://doaj.org/article/b95382d66fb94765915a82c4241d810c
Akademický článek
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Autor:
Ernst, Maria Braune-Yan, Jinfang Jia, Mary Wahba, Johannes Schmid, Panagiotis Papatheodorou, Holger Barth, Katharina
Publikováno v:
Toxins; Volume 15; Issue 6; Pages: 384
Clostridioides difficile infections cause severe symptoms ranging from diarrhea to pseudomembranous colitis due to the secretion of AB-toxins, TcdA and TcdB. Both toxins are taken up into cells through receptor-mediated endocytosis, autoproteolytic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f1baee4b9d995892f457ba8531bd5e64
Akademický článek
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Autor:
Schein, Catherine H.
Publikováno v:
Medicinal Research Reviews
The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many “repurposed” drugs, such as derivatives of thalidomide, antibiotics, and ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a4a93bd3d841ca2ae38dae9327c087
https://doi.org/10.1002/med.21627
https://doi.org/10.1002/med.21627
Publikováno v:
Applied Sciences, Vol 8, Iss 9, p 1512 (2018)
Clostridium difficile infection (CDI) is an increasing global health threat and major worldwide cause of hospital-acquired diarrhea. The development of novel therapies to effectively treat this bacterial pathogen is an unmet clinical need. Here, we d
Externí odkaz:
https://doaj.org/article/f8f008fb34544f37b950f9537147405a
Autor:
Cecilie Knudsen, Andreas H. Laustsen
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 3, Iss 2, p 42 (2018)
With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies. Various technolo
Externí odkaz:
https://doaj.org/article/95ead9805fa44237a04cbbc08edff5ee