Flavonoids and their derivatives as DNA topoisomerase inhibitors with anti-cancer activity in various cell models: Exploring a novel mode of action.

Autor: Sitarek P; Department of Medical Biology, Medical University of Lodz, Muszynskiego 1, Lodz 90-151, Poland. Electronic address: przemyslaw.sitarek@umed.lodz.pl., Merecz-Sadowska A; Department of Economic and Medical Informatics, University of Lodz, Lodz 90-214, Poland., Sikora J; Department of Bioinorganic Chemistry, Medical University of Lodz, Muszynskiego 1, Lodz 90-151, Poland., Dudzic M; Students Research Group, Department of Medical Biology, Medical University of Lodz, Lodz 90-151, Poland., Wiertek-Płoszaj N; Students Research Group, Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, Lodz 90-237, Poland., Picot L; Littoral Environnement et Sociétés UMRi CNRS 7266 LIENSs, La Rochelle Université, La Rochelle 17042, France., Śliwiński T; Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Lodz 90-236, Poland., Kowalczyk T; Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, Lodz 90-237, Poland.

Publikováno v: Pharmacological research [Pharmacol Res] 2024 Nov; Vol. 209, pp. 107457. Date of Electronic Publication: 2024 Oct 09.

The overview of development of novel bacterial topoisomerase inhibitors effective against multidrug-resistant bacteria in an academic environment: From early hits to in vivo active antibacterials.

Autor: Zorman M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia., Hrast Rambaher M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia., Kokot M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia., Minovski N; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, Ljubljana 1001, Slovenia. Electronic address: nikola.minovski@ki.si., Anderluh M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva Cesta 7, Ljubljana 1000, Slovenia. Electronic address: marko.anderluh@ffa.uni-lj.si.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Jan 01; Vol. 192, pp. 106632. Date of Electronic Publication: 2023 Nov 09.

Study of nitrogen heterocycles as DNA/HSA binder, topoisomerase inhibitors and toxicological safety.

Autor: Dos Santos JC; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., Alves JEF; Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, PE, Brazil., de Azevedo RDS; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., de Lima ML; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., de Oliveira Silva MR; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., da Silva JG; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., da Silva JM; Department of Pharmacy, Laboratory of Synthesis and Vectorization of Molecules, State University of Paraíba (UEPB), Campus Campina Grande, 58429-500, PB, Brazil., de Carvalho Correia AC; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil., do Carmo Alves de Lima M; Chemistry and Therapeutic Innovation Laboratory (LQIT), Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil., de Oliveira JF; University of International Integration of Afro-Brazilian Lusophony (UNILAB), 62790-970 Redenção, CE, Brazil., de Moura RO; Department of Pharmacy, Laboratory of Synthesis and Vectorization of Molecules, State University of Paraíba (UEPB), Campus Campina Grande, 58429-500, PB, Brazil., de Almeida SMV; Molecular Biology Laboratory, University of Pernambuco (UPE), Multicampi Garanhuns, Garanhuns, PE 55290-000, Brazil; Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, PE, Brazil; Chemistry and Therapeutic Innovation Laboratory (LQIT), Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: sinara.monica@upe.br.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jan; Vol. 254 (Pt 3), pp. 127651. Date of Electronic Publication: 2023 Nov 08.

Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma.

Autor: Wei X; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Zhang X; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Peng Y; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Wu J; Department of Colorectal Surgery, Hengyang Central Hospital, Hengyang, Hunan, 421001, China., Mo H; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., An Z; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Deng X; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Peng Y; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Liu L; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Jiang W; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Chen J; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China., Hu Z; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: huzecheng@outlook.com., Wang Z; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, 810008, China; National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, 410008, China; MOE Key Lab of Rare Pediatric Diseases, School of Life Sciences, Central South University, Changsha, 410000, China. Electronic address: zhenw@usc.edu.cn., Zhuo L; The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: lszhuo@usc.edu.cn.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 05; Vol. 279, pp. 116807. Date of Electronic Publication: 2024 Sep 01.

Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs.

Autor: Mann CA; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Carvajal Moreno JJ; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Lu Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Dellos-Nolan S; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University , Columbus, Ohio, USA., Wozniak DJ; Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University , Columbus, Ohio, USA., Yalowich JC; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA., Mitton-Fry MJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Oct 18; Vol. 67 (10), pp. e0048223. Date of Electronic Publication: 2023 Sep 19.