Zobrazeno 1 - 10
of 469
pro vyhledávání: '"topk"'
Publikováno v:
Pharmaceutical Sciences, Vol 30, Iss 4, Pp 456-468 (2024)
Background: T-LAK cell-originated protein kinase (TOPK), a member of the MEK3/6-related mitogen-activated protein kinase kinase (MAPKK) family, is highly overexpressed in various cancers. This overexpression is linked to the mitotic phase of the cell
Externí odkaz:
https://doaj.org/article/12b8d52ebe4e44f3959e7db987a3d19c
Autor:
Fanfan Zeng, Shuaixian Du, Mengjun Wu, Chan Dai, Jianyu Li, Jinbiao Wang, Guoyun Hu, Pengcheng Cai, Lin Wang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background T-LAK cell-oriented protein kinase (TOPK) strongly promotes the malignant proliferation of cancer cells and is recognized as a promising biomarker of tumor progression. Psoriasis is a common inflammatory skin disease featured by e
Externí odkaz:
https://doaj.org/article/5fec7ba413484ab8863e56c7e9810632
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)
Abstract Background FYN is a nonreceptor tyrosine kinase that regulates diverse pathological processes. The pro-cancer role of FYN in multiple malignancies has been elucidated. However, the mechanisms that FYN promotes gastric cancer (GC) progression
Externí odkaz:
https://doaj.org/article/ae9b73fac6164b2186d7a142d62cf1f5
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Liang Qiao, Jinling Ba, Jiping Xie, Ruiping Zhu, Yi Wan, Min Zhang, Zeyu Jin, Zicheng Guo, Jiaxuan Yu, Sijing Chen, Yongqiang Yao
Publikováno v:
World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background PDZ-binding kinase/T-lymphokine-activated killer cell-derived protein kinase (PBK/TOPK) is a potential prognostic indicator for patients with breast cancer. The objective of the present study was to explore the relationship betwee
Externí odkaz:
https://doaj.org/article/a072387450f04a88bda9cbe76e72f152
Down-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium
Autor:
Qi Zhu, Simin Yao, Yishan Dong, Dan Liu, Huiyan Wang, Peipei Jiang, Chenyan Dai, Haining Lv, Chenrui Cao, Zhenhua Zhou, Limin Wang, Wenjing Gou, Xiwen Zhang, Guangfeng Zhao, Yali Hu
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Thin endometrium (TE) is a challenging clinical issue in the reproductive medicine characterized by inadequate endometrial thickness, poor response to estrogen and no effective treatments currently. At present, the precise pathoge
Externí odkaz:
https://doaj.org/article/8cd686d1e8cd4856bab9d94975e176f0
Autor:
Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a simil
Externí odkaz:
https://doaj.org/article/406c24e5b9104f00acdc1bc578a5b053
Autor:
Pichaya Thanindratarn, Ran Wei, Dylan C. Dean, Arun Singh, Noah Federman, Scott D. Nelson, Francis J. Hornicek, Zhenfeng Duan
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3721-3737 (2021)
T‐lymphokine‐activated killer (T‐LAK) cell‐originated protein kinase (TOPK) is an emerging target with critical roles in various cancers; however, its expression and function in osteosarcoma remain unexplored. We evaluated TOPK expression usi
Externí odkaz:
https://doaj.org/article/dad7f96840d24a35ade73793916c2808