Rice Husk Silica Liquid Enhances Autophagy and Reduces Overactive Immune Responses via TLR-7 Signaling in Lupus-Prone Models.

Autor: Kao C; Department of Medical Laboratory Science, College of Medical Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan.; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan., Wang SW; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan., Chen PC; Department of Life Science, National Taiwan Normal University, Taipei 116059, Taiwan., Huang CY; Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan., Wei YF; School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.; Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445, Taiwan., Ho CH; Department of Medical Laboratory Science, College of Medical Science and Technology, I-Shou University, Kaohsiung 82445, Taiwan., Hong YH; Graduate Programs of Nutrition Science, National Taiwan Normal University, Taipei 116059, Taiwan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 21; Vol. 25 (18). Date of Electronic Publication: 2024 Sep 21.

Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8 ⁺ T cells.

Autor: Hamade H; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Tsuda M; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Oshima N; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Stamps DT; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Wong MH; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Stamps JT; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Thomas LS; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Salumbides BC; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Jin C; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Nunnelee JS; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Dhall D; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Targan SR; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States., Michelsen KS; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Oct 11; Vol. 15, pp. 1465175. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024).

Stratified analyses refine association between TLR7 rare variants and severe COVID-19.

Autor: Boos J; Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, Germany., van der Made CI; Department of Human Genetics, Department of Internal Medicine, Radboudumc Research Institute for Medical Innovation, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Ramakrishnan G; Department of Medical Biosciences, Radboud University Medical Center, Nijmegen, the Netherlands., Coughlan E; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK; Roslin Institute, University of Edinburgh, Edinburgh, UK., Asselta R; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital - via Manzoni 56, 20089 Rozzano, Milan, Italy., Löscher BS; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany., Valenti LVC; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., de Cid R; Genomes for Life-GCAT Lab, CORE Program. Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain; Grup de Recerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (IGTP), Badalona, Spain., Bujanda L; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain; Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain., Julià A; Vall d'Hebron Hospital Research Institute, Barcelona, Spain., Pairo-Castineira E; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK; Roslin Institute, University of Edinburgh, Edinburgh, UK., Baillie JK; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK; Roslin Institute, University of Edinburgh, Edinburgh, UK., May S; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany., Zametica B; Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, Germany., Heggemann J; Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, Germany., Albillos A; Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain; Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain., Banales JM; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain; Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain., Barretina J; Genomes for Life-GCAT Lab, CORE Program. Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain., Blay N; Genomes for Life-GCAT Lab, CORE Program. Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain; Grup de Recerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) (IGTP), Badalona, Spain., Bonfanti P; Division of Infectious Diseases, Università degli Studi di Milano Bicocca, Fondazione San Gerardo dei Tintori, Monza, Italy., Buti M; Centre for Biomedical Network Research on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, 28029 Madrid, Spain., Fernandez J; Hospital Clinic, University of Barcelona, Barcelona, Spain; European Foundation for the Study of Chronic Liver Failure (EF CLif), Barcelona, Spain., Marsal S; Vall d'Hebron Hospital Research Institute, Barcelona, Spain., Prati D; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Ronzoni L; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Sacchi N; IBMDR, E.O. Ospedali Galliera, Genova, Italy., Schultze JL; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany; Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. and University of Bonn, Bonn, Germany., Riess O; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany; DFG NGS Competence Center Tübingen (NCCT), University of Tübingen, Tübingen, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany., Rawlik K; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Ellinghaus D; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany., Hoischen A; Department of Human Genetics, Department of Internal Medicine, Radboudumc Research Institute for Medical Innovation, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Schmidt A; Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, Germany., Ludwig KU; Institute of Human Genetics, University of Bonn School of Medicine and University Hospital Bonn, Bonn, Germany. Electronic address: kerstin.ludwig@uni-bonn.de.

Publikováno v: HGG advances [HGG Adv] 2024 Oct 10; Vol. 5 (4), pp. 100323. Date of Electronic Publication: 2024 Jun 28.

Conjugation of TLR7 and TLR7/8 agonists onto weak protein antigen via versatile oxime ligation for enhanced vaccine efficacy.

Autor: Zhang RY; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China; Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi 435003, China., Wen Y; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., He CB; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., Zhou SH; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., Wu YH; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., Wang EY; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., Feng RR; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., Ding D; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China., Du JJ; Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, College of Medicine, Hubei Polytechnic University, Huangshi 435003, China., Gao XF; Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, School of Chemistry and Materials Science, East China University of Technology, Nanchang 330013, China., Guo J; National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address: jguo@ccnu.edu.cn.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2024 Oct; Vol. 278 (Pt 1), pp. 134620. Date of Electronic Publication: 2024 Aug 09.

Clinical significance of TLR7/IL-23/IL-17 signaling pathway in patients with acute respiratory distress syndrome.

Autor: Chu L; The First People's Hospital of Huzhou, Huzhou, Zhejiang, PR China., Liu F; The First People's Hospital of Huzhou, Huzhou, Zhejiang, PR China., Tang K; The First People's Hospital of Huzhou, Huzhou, Zhejiang, PR China. Electronic address: HYICU5158@126.com.

Publikováno v: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2024 Sep 11; Vol. 79, pp. 100358. Date of Electronic Publication: 2024 Sep 11 (Print Publication: 2024).